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Hemolytic Anemia

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A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).

Also Known As:

Anemia, Hemolytic; Hemolytic Anemia, Acquired; Acquired Hemolytic Anemia; Anemia, Acquired Hemolytic; Hemolytic Jaundice; Hemolytic Jaundices; Jaundices, Hemolytic; Microangiopathic Anemia; Anemia, Hemolytic, Acquired; Anemia, Microangiopathic; Jaundice, Hemolytic

Networked: 3619 relevant articles (96 outcomes, 162 trials/studies)

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases
- Hematologic Diseases: 1962
  - Anemia: 22925
    - Hemolytic Anemia: 3619

Related Diseases

1.	Thrombocytopenia (Thrombopenia)
2.	Infection
3.	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
4.	Methemoglobinemia
5.	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)

Experts

1.	Garratty, George: 13 articles (01/2014 - 08/2002)
2.	Zanella, Alberto: 11 articles (09/2015 - 09/2004)
3.	Salama, Abdulgabar: 9 articles (01/2014 - 03/2003)
4.	Fermo, Elisa: 9 articles (01/2013 - 09/2004)
5.	Gladwin, Mark T: 7 articles (08/2011 - 07/2003)
6.	McMillan, David C: 7 articles (12/2005 - 10/2002)
7.	Jollow, David J: 7 articles (12/2005 - 10/2002)
8.	Brodsky, Robert A: 6 articles (12/2015 - 04/2008)
9.	Gallagher, Patrick G: 6 articles (09/2015 - 12/2005)
10.	Arndt, Patricia A: 6 articles (01/2014 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemolytic Anemia:

1.	Prednisolone (Predate)FDA LinkGeneric 05/01/2009 - "After oral prednisolone administration (1 mg/kg/day), her hemolytic anemia rapidly improved." 12/01/1968 - "[Immunohematological studies on the effect of prednisolone in experimental hemolytic anemia]." 08/01/1996 - "As of the time of this writing, she has no relapse of hemolytic anemia though prednisolone was discontinued 6 months ago." 10/01/1991 - "The PRCA and hemolytic anemia were successfully treated with prednisolone (60 mg/day). " 08/01/1998 - "Further administration of 60 mg of prednisolone and plasmapheresis ameliorated the hemolytic anemia and cured the jaundice. "
2.	Ribavirin (Virazole)FDA LinkGeneric 05/01/2011 - "However, the use of ribavirin in dialysis patients has been limited by the high frequency of severe hemolytic anemia and is currently reserved for study protocols and highly selected candidates treated at experienced centers. " 01/01/2015 - "Relationship between ITPA polymorphisms and hemolytic anemia in HCV-infected patients after ribavirin-based therapy: a meta-analysis." 12/01/2014 - "However, ribavirin induces severe side effects such as hemolytic anemia. " 11/01/2014 - "Antiviral therapy was neither effective nor safe; ribavirin was stopped at week 38 due to hemolytic anemia; on-treatment HCV breakthrough was observed at week 48; and acute rejection occurred after four months of IFN-based therapy. " 07/01/2013 - "In addition, ribavirin (RBV), commonly associated with hemolytic anemia, often requires dose adjustment, advocating for therapeutic drug monitoring (TDM) in patients under combined antiviral therapy. "
3.	rituximab (Mabthera)FDA Link 11/01/2001 - "In individual cases, Rituximab has the potential of achieving not only a complete clinical remission (CR) but also a molecular CR, as well as a "functional" CR, by eliminating the clinical manifestations of autoimmunity; in this case, cold agglutinin mediated hemolytic anemia, secondary to NHL. " 08/01/2013 - "Hemolytic anemia improved rapidly, and there were no severe adverse effects caused by rituximab. " 04/01/2015 - "This study aims to evaluate the response to rituximab (RTX) treatment in auto-immune hemolytic anemia (AIHA) patients. " 04/01/2015 - "Efficacy and safety of rituximab in auto-immune hemolytic anemia: A meta-analysis of 21 studies." 08/01/2015 - "Emergence of long-lived autoreactive plasma cells in the spleen of primary warm auto-immune hemolytic anemia patients treated with rituximab."
4.	Dapsone FDA Link 01/01/1988 - "The hemolytic anemia which frequently accompanies treatment of individuals with dapsone and other arylamine drugs is believed to be caused not by the parent drugs per se, but rather by metabolites which are formed during the clearance of the drugs in vivo. " 09/01/2012 - "Dapsone is known to cause hemolytic anemia (HA) and this adverse event during MDT seems to be more frequent than reported. " 05/01/2010 - "Overall, topical dapsone gel has a favorable short- and long-term safety profile and has been shown to have no risk of hemolytic anemia, including in G6PD deficient patients. " 11/01/2008 - "We report a high prevalence of hemolytic anemia (HA) associated with dapsone use in LT patients when compared with other patients described in the literature who have been prescribed dapsone prophylaxis. " 12/01/1998 - "These data suggest that lipid peroxidation is not involved in the mechanism underlying dapsone-induced hemolytic anemia."
5.	Pyruvate KinaseIBA 03/15/1998 - "Delayed onset of hemolytic anemia in CBA-Pk-1slc/Pk-1slc mice with a point mutation of the gene encoding red blood cell type pyruvate kinase." 06/01/2014 - "A two-year-old male baby with severe hemolytic anemia and low level of pyruvate kinase (PK) activity was enrolled in this study. " 05/08/1999 - "[Molecular study of red cell pyruvate kinase deficiency in 15 patients with chronic hemolytic anemia. " 04/01/1995 - "Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia." 01/01/1995 - "Study of the molecular defects in pyruvate kinase deficient patients affected by nonspherocytic hemolytic anemia."
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/1969 - ""Mechanical" hemolytic anemia improved by corticosteroids. " 02/01/1992 - "Her clinical course was complicated by intractable hemolytic anemia that was initially treated with corticosteroids. " 06/01/1993 - "With the administration of corticosteroids, hemolytic anemia improved temporarily, but the patient died of hemorrhagic gastritis. " 09/01/1990 - "Whether corticosteroids have value in decreasing the severity of hemolytic anemia due to cold agglutinin and other protean extrapulmonary manifestations with M pneumoniae infection needs further controlled study. " 12/01/2011 - "He had been treated with antimicrobials and corticosteroids for interstitial pneumonia caused by Mycoplasma pneumoniae and hemolytic anemia. "
7.	AntibodiesIBA 10/01/1989 - "Life-threatening hemolytic anemia combined with the presence of multiple antibodies and lack of erythroid precursors was treated successfully with a single dose of intravenous gammaglobulin. " 11/01/1947 - "The improved demonstration of circulating antibodies in hemolytic anemia by the use of a bovine albumin medium; parallelism with survival time of transfused red cells." 07/01/1947 - "The improved demonstration of circulating antibodies in hemolytic anemia by the use of a bovine albumin medium." 03/01/1991 - "These studies indicate that RBC antibodies are found in a restricted number of IEF fractions in sera from some patients with immune hemolytic anemia. " 01/01/1964 - "[IMMUNOLOGICAL AND ISOTOPE STUDY OF HEMOLYTIC ANEMIA WITH SPECIFIC "ANTI-NL" ANTIBODIES]."
8.	BilirubinIBA 01/01/1996 - "We conclude that in young rats, hemolytic anemia does not increase the acute entry of bilirubin into brain, nor does it affect the clearance of bilirubin from brain." 01/01/1996 - "Hemolytic anemia does not increase entry into, nor alter rate of clearance of bilirubin from rat brain." 01/01/1991 - "We conclude that moderate non-hemolytic jaundice (serum bilirubin 12-15 mg/dl) does not affect the behavior of full-term infants in this study. " 10/01/1961 - "Studies of chronic familial non-hemolytic jaundice with conjugated bilirubin in the serum with and without an unidentified pigment in the liver cells." 01/01/2012 - "Hemolytic anemia usually gives rise to only a modest elevation of serum bilirubin. "
9.	InterferonsIBA 05/01/1994 - "This is, to our knowledge, the first report of chronic hepatitis C complicated by Coombs-negative hemolytic anemia during interferon treatment." 05/01/1994 - "Chronic hepatitis C complicated by Coombs-negative hemolytic anemia during interferon treatment." 10/01/1991 - "Hemolytic anemia secondary to interferon treatment for chronic B hepatitis." 01/01/1991 - "Interferon therapy for agnogenic myeloid metaplasia complicated by immune hemolytic anemia." 12/01/1994 - "[Coomb's-positive hemolytic anemia and tuberculosis in Kaposi's sarcoma treated with interferon]."
10.	ecabapideIBA 08/01/1996 - "A possible mechanism of heinz body hemolytic anemia induced by DQ-2511, a new gastroprokinetic drug, in dogs." 02/01/1993 - "Hemolytic anemia disappeared after a 4-week recovery period in the dogs that received DQ-2511. " 02/01/1993 - "Heinz body hemolytic anemia induced by DQ-2511, a new anti-ulcer drug, in dogs." 08/01/1996 - "A previous study revealed that DQ-2511, a new gastroprokinetic drug, induced hemolytic anemia together with increased Heinz body formation, preceded by a marked decrease in erythrocyte reduced glutathione (GSH) content, after 2 weeks of dosing onward in dogs. " 02/01/1993 - "DQ-2511, a new anti-ulcer drug, was administered to beagle dogs for 4 weeks to investigate the mechanism whereby this drug induced hemolytic anemia and its reversibility in comparison with beta-acetylphenylhydrazine. "

Therapies and Procedures

1.	Splenectomy 08/01/1996 - "This is the first reported case of such an association in which poorly controlled auto-immune hemolytic anemia benefited from splenectomy." 03/01/1993 - "This patient suffered from moderate hemolytic anemia that improved after splenectomy. " 10/01/1962 - "[Case of familial hemolytic jaundice greatly improved by splenectomy]." 03/01/1961 - "[Study of erythrocytic resistance in 12 cases of constitutional hemolytic anemia before and after splenectomy]." 08/01/1946 - "Splenectomy in familial hemolytic jaundice; study and cure of patient with normal erythrocyte fragility and other unusual features."
2.	Phototherapy (Light Therapy) 04/01/1990 - "The frequency of exchange transfused neonates with iso-Rh and iso-ABO decreased or remained stationary on account of the confirmed relative lesser efficacy of phototherapy on hemolytic jaundice. " 01/01/2009 - "To evaluate the efficacy of white reflecting material (slings) hung from the sides of compact fluorescent lamp (CFL) phototherapy equipment in reducing the duration of phototherapy in healthy term neonates with non-hemolytic jaundice. " 11/01/2002 - "To compare the efficacy of double phototherapy and conventional phototherapy in term newborn infants with hemolytic jaundice. " 01/01/1984 - "[Efficacy of intensive blue double-lamp phototherapy in the treatment of ABO incompatibility and idiopathic severe hemolytic jaundice]." 01/01/2010 - "A total of 492 liveborn infants who were of >or=34 weeks' gestation and had severe isoimmune hemolytic jaundice caused by Rh (n = 91) and ABO (n = 401) incompatibility and were treated with phototherapy were included in the study. "
3.	Plasma Exchange 01/01/1985 - "A therapeutic trial of plasma exchange was conducted in an 82-year-old woman with severe cold agglutinin hemolytic anemia, who was unresponsive to conventional treatment. " 03/01/2015 - "Transfusion medicine illustrated: An unusual case of near-fatal hemolytic anemia treated with erythrocytapheresis and therapeutic plasma exchange." 01/01/1987 - "Successful use of plasma exchange in a child with refractory immune hemolytic anemia." 11/01/1985 - "[Plasma exchange in 2 cases of hemolytic anemia]." 01/01/1985 - "Inefficacy of plasma exchange in cold agglutinin hemolytic anemia--a case study."
4.	Renal Dialysis (Hemodialysis) 07/01/1993 - "During the four month period, from December 1988 to March 1989, there was an outbreak of Heinz body positive hemolytic anemia in 34 patients undergoing hemodialysis in a 500-bed hospital, Seoul, Korea. " 07/01/1993 - "An outbreak of Heinz body positive hemolytic anemia in chronic hemodialysis patients." 08/03/1973 - "Unexplained acute hemolytic anemia is sometimes seen in uremic patients undergoing hemodialysis. " 06/01/1999 - "Hemolytic anemia and the temporarily deteriorated renal function were improved after hemodialysis and plasma exchange. " 04/01/2011 - "Plasma exchange and hemodialysis were performed because of progressive hemolytic anemia and renal dysfunction. "
5.	Plasmapheresis 08/01/2009 - "To investigate the clinical application and potential utility of plasmapheresis in canine immune-mediated hemolytic anemia. " 08/01/2009 - "Use of therapeutic plasmapheresis in a case of canine immune-mediated hemolytic anemia." 06/01/2005 - "Plasmapheresis is the technique of choice for severe hemolytic anemia patients. " 01/01/2014 - "Early recognition of the systemic insult associated with carboplatin induced hemolytic anemia may allow for future affected patients to receive plasmapheresis, a potentially effective therapy. " 08/01/1998 - "Further administration of 60 mg of prednisolone and plasmapheresis ameliorated the hemolytic anemia and cured the jaundice. "