Aplastic Anemia (Anemia, Hypoplastic)

08/01/1987 - "Antithymocyte globulin (ATG), a horse antihuman thymus antiserum highly effective in the majority of patients with aplastic anemia, was studied for its in vitro effects on hematopoietic progenitor cells. "
12/01/1989 - "In contrast, two kinds of antilymphocyte globulin (ALG) were effective for 9.4% and 15.6% of the severe form of aplastic anemia, and two kinds of antithymocytoglobulin (ATG) were effective in 30.8% and 37.2% of the patients, although the difference between ALG and ATG was not statistically significant. "
09/01/2010 - "The aim of this study was to compare hematological response and overall survival in patients submitted to horse or rabbit antithymocyte globulin as first-line treatment for severe aplastic anemia. "
05/15/1991 - "Therapy with antilymphocyte globulin (ALG) has been shown to be effective in restoring hematopoiesis to some patients with aplastic anemia. "
01/20/1983 - "These data indicate that antithymocyte globulin is effective in improving hematopoiesis in some patients with aplastic anemia."

01/01/2011 - "Advanced age, SAA without very severe aplastic anemia, and combination of anti-lymphocyte globulin with cyclosporine A were factors for improved survival in the immunosuppressive group. "
01/01/2011 - "Advanced age, SAA without very severe aplastic anemia, and combination of anti-lymphocyte globulin with cyclosporine A were factors for improved survival in the IST group. "
07/01/1989 - "According to recent reports, cyclosporin (CsA) has been proven to be a cure for some patients with severe aplastic anemia (SAA). "
07/01/2014 - "The use of ATG-Fresenius S plus cyclosporine as a first-line immunosuppressive treatment appeared to be effective for children with severe aplastic anemia in our study. "
05/15/1992 - "Cyclosporine (CyA) therapy has been shown to be effective in some patients with aplastic anemia. "

12/01/1995 - "Combination therapy consisting of G-CSF and EPO may be beneficial for patients with aplastic anemia."
01/01/2000 - "Combination therapy with G-CSF and EPO may be safe and effective for elderly patients with aplastic anemia when the choice of therapy is limited."
09/15/2007 - "We report the results of a randomized study to elucidate whether addition of granulocyte colony-stimulating factor (G-CSF) to immunosuppressive therapy is valuable for the treatment of severe aplastic anemia (SAA) in adults. "
11/01/2015 - "Aplastic anemia patients received granulocyte colony-stimulating factor more frequently and for longer durations than other patients (P<0.01). "
11/01/2014 - "To testify whether absolute neutrophil count (ANC) response to preimmunosuppressive-therapy (pre-IST) granulocyte-stimulating factor (G-CSF) treatment could predict early response to IST in severe aplastic anemia (SAA). "

12/15/1998 - "Immunoablative high-dose cyclophosphamide without stem-cell rescue induces durable, complete remission in most patients with aplastic anemia. "
07/15/2002 - "High-dose cyclophosphamide, without stem cell rescue, has been used successfully to treat aplastic anemia and other autoimmune disorders. "
10/02/2001 - "To confirm the safety and efficacy of high-dose cyclophosphamide therapy alone in patients with severe aplastic anemia. "
10/02/2001 - "Durable treatment-free remission after high-dose cyclophosphamide therapy for previously untreated severe aplastic anemia."
12/01/2004 - "We conclude that the conditioning regimen containing cyclophosphamide and anti-CD52 MoAb is well tolerated and effective for acquired aplastic anemia with HLA-matched sibling donors. "

07/01/1986 - "[Clinico-hematological studies on the activity of serum erythropoietin and erythropoiesis in hypoplastic anemia]."
01/01/2010 - "For example, a change to the closure system for erythropoietin led to an increase in aplastic anemia as a result of changing the immunogenicity characteristics of the protein. "
03/01/1998 - "Erythropoietin therapy for aplastic anemia."
02/01/1998 - "We examined the pharmacokinetics of recombinant human erythropoietin (rh-EPO) in genetically anemic mice (W/Wv genotype) to clarify its disposition mechanism in hematopoietic injury such as occurs in aplastic anemia. "
01/01/1998 - "Hypoplastic anemias (AHC) on the other hand, are accompanied by significantly larger increases in the erythropoietin concentration. "

04/01/1990 - "Therefore, a diagnosis of aplastic anemia was made, and bolus methylprednisolone therapy (1,000 mg/day x 3 days) was performed, which brought the patient to complete remission. "
04/01/1990 - "[Aplastic anemia associated with minimal serum M-protein treated successfully with repeated bolus methylprednisolone therapy]."
09/01/1995 - "A 19-year-old man was diagnosed as having severe aplastic anemia and received high-dose methylprednisolone treatment without hematological response. "
01/01/1993 - "Between January 1986 and July 1990, 17 patients with acquired aplastic anemia were treated with ALG or ATG combined with high doses of methylprednisolone. "
04/01/1991 - "Four males and two females, aged 13 to 57 years (median 22 years), with acquired severe aplastic anemia (AA) were treated with intravenous bolus of high doses of 6-methylprednisolone (MPL). "

01/01/1992 - "It is concluded that the combination of rHu GM-CSF and glucocorticosteroids can be used as a therapeutic option that may lead to beneficial results in drug-induced aplastic anemia."
12/22/1988 - "These results indicate that recombinant human GM-CSF is effective in stimulating myelopoiesis in patients with severe aplastic anemia and may benefit some patients in whom the disorder is refractory to standard forms of therapy."
07/01/1995 - "In the aplastic anemia trial, 9 out of 12 patients had some improvement when treated with GM-CSF. "
01/01/1992 - "Clinical trials of granulocyte-macrophage colony-stimulating factor for the treatment of aplastic anemia."
09/15/1990 - "A phase I/II trial of recombinant granulocyte-macrophage colony-stimulating factor for children with aplastic anemia."

09/29/1979 - "[Immunosuppression, bone marrow infusion and low dose androgens, successful therapy of severe aplastic anemia]."
08/01/1984 - "Thus androgens may be particularly useful in the treatment of SLE-associated aplastic anemia."
05/01/1984 - "These results indicate that an in vitro CFU-E culture system to the presence of FMT may be helpful in predicting the response to androgens in vivo in patients with aplastic anemia."
01/01/2015 - "We searched the Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Full-text Database (VIP), Wanfang Database, PubMed and EMBASE database to collect the data about the trials of Huangqi injection combined with androgens for treating aplastic anemia. "
02/01/2009 - "[Preliminary study on predictors for selection of immunosuppressive therapy or androgens in treating aplastic anemia patients]."

03/01/2010 - "HSCT would be the treatment of choice in children with severe aplastic anemia who have a human leukocyte antigen (HLA)-matched related donor and is superior to IST in this series from India."
02/01/2007 - "FZYYG can induce the bcl-2 antigen expression and postpone the haematogenous cells apoptosis, and it is effective for mice with immune mediated aplastic anemia."
08/01/2014 - "Epidemiologic and HLA antigen profile in patients with aplastic anemia."
08/01/2014 - "The human leukocyte antigen (HLA) system has been reported to be involved in the development of aplastic anemia (AA). "
08/01/2014 - "The polymorphisms of human leukocyte antigen loci may contribute to the susceptibility and severity of severe aplastic anemia in Chinese patients."

07/01/2013 - "Hematologic responses in patients with aplastic anemia treated with deferasirox: a post hoc analysis from the EPIC study."
05/01/2012 - "Deferasirox therapy in children with Fanconi aplastic anemia."
10/07/2010 - "This prospective dataset confirms the efficacy and well characterizes the tolerability profile of deferasirox in a large population of patients with aplastic anemia. "
07/01/2013 - "Alongside reduction in iron overload, deferasirox may, therefore, improve hematologic parameters in a subset of aplastic anemia patients. "
07/01/2015 - "This study was an open-label, single-arm, prospective clinical study to evaluate the efficacy and safety of deferasirox (DFX) in patients with aplastic anemia (AA), myelodysplastic syndrome (MDS), or acute myeloid leukemia (AML). "

05/09/1991 - "Immunosuppression is the most effective treatment for patients with aplastic anemia, except for bone marrow transplantation. "
01/01/1989 - "Although HLA-matched bone marrow transplantation leads to a faster and more complete recovery for children with aplastic anemia, immunosuppressive therapy can provide a good outcome for children with this disorder."
07/01/1980 - "Bone marrow transplantation has proved to be very helpful in the treatment of aplastic anemia and has provided impetus for increased knowledge concerning the pathogenesis of the aplasia. "
04/01/2009 - "Acquired severe aplastic anemia can be treated successfully with either immunosuppressive therapy or bone marrow transplantation. "
01/01/2004 - "Given this, it has been suggested that allogenic bone marrow transplantation (BMT) possibly could be a cure for FOP, and drawn attention to a previously unappreciated case of an FOP patient who had successful BMT for aplastic anemia with apparent short- and medium-term arresting of the FOP disease process. "

09/01/2005 - "Immunosuppression is the most effective treatment for aplastic anemia after hematopoietic stem cell transplantation. "
10/01/2014 - "This study was purposed to evaluate the curative efficacy of second allogeneic hematopoietic stem cell transplantation (allo-HSCT) after failure of the first allo-HSCT in aplastic anemia patients, the cause of implant failure after allo-HSCT and clinical data of 10 severe aplastic anemia (SAA) patients in the second allo-HSCT were retrospectively analyszed. "
06/01/2015 - "Survival in severe aplastic anemia (SAA) has markedly improved in the past 2 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. "
04/01/2014 - "Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. "
08/09/2012 - "Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive biologics and drugs, and supportive care. "

06/01/1987 - "This preoperative regimen is extremely effective in decreasing rejection following transplantation for severe aplastic anemia. "
09/01/1983 - "Twenty-nine of the 40 transplanted patients are surviving from 1.5 to 59 mo, with a median follow-up of 24 mo. The actuarial survival rate for these heavily transfused patients with aplastic anemia is 72% at 2 yr. This preparative regimen is extremely effective in decreasing rejection following transplantation for severe aplastic anemia. "
08/01/1991 - "Allogeneic marrow transplantation from an HLA-identical sibling has proven to be an effective treatment for severe aplastic anemia with restoration of normal hematopoiesis and long-term survival in 70-80% of recipients. "
05/01/2010 - "Successful first-line treatment with double umbilical cord blood transplantation in severe aplastic anemia."
02/01/2002 - "Survival of patients with aplastic anemia treated with transplantation of bone marrow has improved significantly over the past several decades. "

06/01/2010 - "This study confirms positive results of alternative donor transplants in patients with severe aplastic anemia, the best outcomes being achieved in patients grafted within 2 years of diagnosis. "
09/01/2011 - "Even a very high risk patient with aplastic anemia who had undergone two consecutive transplants due to secondary graft failure was also cured of his primary disease despite the presence of multiple pulmonary fungus balls. "
11/01/2004 - "We present a case of a 13-year-old boy who was diagnosed at age four with idopathic aplastic anemia, was treated successfully with an allogeneic bone marrow transplant, then subsequently developed skin, nail, and tongue lesions. "
02/01/2004 - "In total, 64% were in remission or in chronic phase or had aplastic anemia (good risk), and 36% had active disease at the time of transplant (bad risk). "
11/01/2014 - "This article reviews recent developments in immunosuppressive therapy (IST) for aplastic anemia (AA) patients who are not candidates for stem cell transplant (SCT); including, front-line, salvage, and novel treatment options with a focus on response rates (RRs) and overall survival (OS). "

05/01/2007 - "Unrelated stem cell transplantation for severe acquired aplastic anemia: improved outcome in the era of high-resolution HLA matching between donor and recipient."
10/01/2014 - "This study was purposed to investigate the therapeutic efficacy of haploidentical allogeneic hemopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA), and evaluate the safety of this treatment by retrospective analysis. "
03/05/2003 - "Aplastic anemia can be effectively treated by stem cell transplantation or immunosuppression. "
04/02/2002 - "Aplastic anemia can be effectively treated by stem-cell transplantation or immunosuppressive therapy. "
02/01/2008 - "We conducted a prospective multicenter study to compare the efficacy of repeated immunosuppressive therapy (IST) with stem-cell transplantation (SCT) from an alternative donor in children with acquired aplastic anemia (AA) who failed to respond to an initial course of IST. "