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Androstenes

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Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Androstanes: 8
    - Androstenes: 4

Experts

1.	Loria, Roger M: 3 articles (12/2009 - 11/2002)
2.	Jia, Wentao: 1 article (12/2009)
3.	Lewbart, Marvin L: 1 article (12/2009)
4.	Graf, Martin R: 1 article (12/2009)
5.	Bottasso, Oscar: 1 article (01/2009)
6.	Morales-Montor, Jorge: 1 article (01/2009)

Related Diseases

1.	Bacterial Infections (Bacterial Infection) 01/01/2009 - "Beta-androstenes and resistance to viral and bacterial infections." 01/01/2009 - "Moreover, the influence of beta-androstenes on resistance to viral and bacterial infections is discussed, as well as the impact of infectious diseases upon neuroendocrine circuits. " 11/01/2002 - "These androstenes also protected the host from lethal bacterial infections by Enterococcus faecalis, Pseudomonas aeruginosa, and Klebsiella pneumonia and from parasites infections, i.e. "
2.	Infection 01/01/2009 - "This report illustrates that the beta-androstenes are indeed able to upregulate the host immune response to a level that enables the host to resist lethal infection by viruses or bacteria. " 11/01/2002 - "beta Androstenes steroid up-regulates immunity to increase resistance against lethal infection and lethal radiation, and mediates a rapid recovery of hematopoietic precursor cells after radiation injury. " 11/01/2002 - "These androstenes also protected the host from lethal bacterial infections by Enterococcus faecalis, Pseudomonas aeruginosa, and Klebsiella pneumonia and from parasites infections, i.e. " 11/01/2002 - "Our findings show that beta androstenes and analogs protect the host from lethal infection by DNA or RNA viruses such as, herpesvirus type 2, coxsackievirus B4, influenza, and arthropod borne viruses. "
3.	Radiation Injuries (Radiation Sickness) 11/01/2002 - "beta Androstenes steroid up-regulates immunity to increase resistance against lethal infection and lethal radiation, and mediates a rapid recovery of hematopoietic precursor cells after radiation injury. "
4.	Pneumonia (Pneumonitis) 11/01/2002 - "These androstenes also protected the host from lethal bacterial infections by Enterococcus faecalis, Pseudomonas aeruginosa, and Klebsiella pneumonia and from parasites infections, i.e. "
5.	Neoplasms (Cancer) 12/01/2009 - "These results indicate that the position of the hydroxyl group on C-17 dictates the anti-tumor activity of the androstenes and must be in the alpha-configuration, demonstrating a strict structure-activity relationship." 12/01/2009 - "We synthesized a new androstene by adding a third hydroxyl group at C-7 to make 5-androstene-3beta,7alpha,17alpha-triol (3beta,7alpha,17alpha-AET) and compared the anti-tumor activity of this steroid to the four existing androstenes. "

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