Androgen Antagonists (Antiandrogens)

Compounds which inhibit or antagonize the biosynthesis or actions of androgens.

Also Known As:

Antiandrogens; Anti-Androgen Effect; Anti-Androgen Effects; Antiandrogen Effect; Antiandrogen Effects; Antagonist, Androgen; Antagonists, Androgen; Anti Androgen Effect; Anti Androgen Effects; Effect, Anti-Androgen; Effect, Antiandrogen; Effects, Anti-Androgen; Effects, Antiandrogen; Androgen Antagonist; Antiandrogen

Networked: 1989 relevant articles (192 outcomes, 275 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chang, Chawnshang: 25 articles (11/2021 - 11/2002)
2.	Sawyers, Charles L: 18 articles (10/2020 - 01/2004)
3.	Yeh, Shuyuan: 12 articles (01/2021 - 05/2002)
4.	Wongvipat, John: 12 articles (10/2020 - 05/2009)
5.	Labrie, Fernand: 11 articles (11/2018 - 12/2002)
6.	Niu, Yuanjie: 9 articles (10/2020 - 11/2015)
7.	Gao, Allen C: 9 articles (01/2020 - 07/2006)
8.	Rennie, Paul S: 9 articles (10/2017 - 05/2007)
9.	Antonarakis, Emmanuel S: 8 articles (01/2022 - 01/2016)
10.	Sun, Yin: 8 articles (11/2021 - 11/2017)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 04/15/2007 - "The new steroidal compound, 15, thus constitutes a good starting point for development of future antiandrogens with a therapeutic potential against prostate cancer." 03/01/2015 - "Our results indicate that therapeutic targeting of AR in prostate cancer using antiandrogens may be substantially improved by targeting of Stat5a/b." 12/20/1990 - "We conclude that this compound seems as effective as other antiandrogens, but with improved compliance, and shows less side effects in the management of advanced prostatic cancer." 10/01/1993 - "The claimed ability of non-steroidal antiandrogens to preserve libido and sexual potency is sought as a potential improvement in the palliative management of prostate cancer. " 09/01/2023 - "Randomized controlled trials are warranted to clearly define the role of novel antiandrogens in the treatment of prostate cancer. "
2.	Hirsutism 07/01/1999 - "Antiandrogens are effective in the treatment of hirsutism. " 10/01/1988 - "Assessing changes in scalp hair growth may be difficult, however, and hirsutism provides a useful model for testing the efficacy of topical antiandrogens. " 04/01/2008 - "The relative efficacy of antiandrogens for the treatment of hirsutism remains unclear. " 01/01/2007 - "Antiandrogens are usually required for a substantial improvement in hirsutism score. " 04/01/2008 - "Eligible studies were RCTs of at least 6 months of antiandrogen use in women with hirsutism. "
3.	Neoplasms (Cancer) 01/01/2023 - "The new antagonists exhibited improved in vivo pharmacokinetics (PK) with high efficacy antiandrogen activity in Hershberger and antiandrogen Enz-Res tumor xenograft models that overexpress AR (LNCaP-AR)." 03/01/2015 - "In this study the combination of a 5α-reductase inhibitor and (novel) antiandrogens synergistically inhibited tumor cell proliferation. " 07/01/2001 - "Twenty-four patients with metastatic HRPC and progressive tumor after antiandrogen withdrawal were enrolled in this study. " 02/01/1991 - " In vitro studies demonstrate that pure antiandrogens significantly inhibit about 60% of ovarian tumors. " 11/29/2023 - "By employing a ubiquitination-based AR degrader to adeptly restore AR ubiquitination, we reestablished AR degradation and inhibited the proliferation of antiandrogen-resistant PCa tumors. "
4.	Acne Vulgaris 06/01/2023 - "Historically, although systemic antiandrogen acne medications have been effective in women, the utility of these systemic medications has been limited due to potential systemic side effects in men and pregnant women. " 08/01/2002 - "A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women." 04/01/2020 - "Recognizing the preliminary evidence, more peer-reviewed studies on topical antiandrogen treatments for AGA and acne vulgaris are necessary before definitive recommendations can be made regarding efficacy and safety. " 09/01/2021 - "The approval of a first-in-class topical androgen antagonist is indeed a 'game-changer' for acne management. " 01/01/2021 - "Advanced understanding of the action mechanisms of classical acne treatment and new development of antiandrogens, both topical and systemic, are also highlighted."
5.	Carcinoma (Carcinomatosis) 10/01/2003 - "Long-term outcome of antiandrogen monotherapy in advanced prostate carcinoma: 12-year results of a phase II study." 12/01/1983 - "In addition, antiandrogens are receiving limited trials in the treatment of laryngeal carcinoma. " 01/01/1981 - "The goal of this study was to achieve clinical application of antiandrogens for the treatment of carcinoma of the prostate. " 01/01/2022 - "Although AR expression is a hallmark of apocrine carcinoma, little is known regarding the efficacy/resistance to antiandrogens. " 08/01/2006 - "Univariate Kaplan-Meier analysis showed that patients with grade 3 carcinoma had a worse prognosis than those with better differentiated carcinoma, whereas antiandrogen pretreatment had no influence on overall survival or relapse-free survival. "

Related Drugs and Biologics

1.	Androgens
2.	Flutamide (Eulexin)
3.	Gonadotropin-Releasing Hormone (GnRH)
4.	Hormones (Hormone)
5.	Cyproterone Acetate
6.	enzalutamide
7.	Androgen Receptors (Androgen Receptor)
8.	Oral Contraceptives
9.	Spironolactone (Aldactone)
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Drug Therapy (Chemotherapy)
4.	Orchiectomy (Orchidectomy)
5.	Radiotherapy