Androgen Antagonists (Antiandrogens)

04/15/2007 - "The new steroidal compound, 15, thus constitutes a good starting point for development of future antiandrogens with a therapeutic potential against prostate cancer."
09/15/2009 - "Our preclinical data suggest that combination of antiandrogens with mTOR inhibitors might be more effective in treating androgen-dependent prostate cancer patients."
03/01/2015 - "Our results indicate that therapeutic targeting of AR in prostate cancer using antiandrogens may be substantially improved by targeting of Stat5a/b."
12/20/1990 - "We conclude that this compound seems as effective as other antiandrogens, but with improved compliance, and shows less side effects in the management of advanced prostatic cancer."
10/01/1993 - "The claimed ability of non-steroidal antiandrogens to preserve libido and sexual potency is sought as a potential improvement in the palliative management of prostate cancer. "

07/01/1999 - "Antiandrogens are effective in the treatment of hirsutism. "
10/01/1988 - "Assessing changes in scalp hair growth may be difficult, however, and hirsutism provides a useful model for testing the efficacy of topical antiandrogens. "
04/01/2008 - "The relative efficacy of antiandrogens for the treatment of hirsutism remains unclear. "
01/01/2007 - "Antiandrogens are usually required for a substantial improvement in hirsutism score. "
04/01/2008 - "We performed a systematic review and metaanalyses of randomized controlled trials (RCTs) evaluating the effect of antiandrogens on hirsutism. "

08/01/2002 - "A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women."
07/01/2011 - "This pilot study supports the rationale for the use of topical antiandrogens in the treatment of acne vulgaris. "
03/01/2010 - "[Hormonal antiandrogens in acne treatment]."
03/01/2010 - "Modern acne therapy is based on the application of anticomedogenic, antimicrobial, or antiinflammatory substances, and antiandrogens. "
02/01/2005 - "The mainstays of modern acne therapy include comedolytic, antimicrobial, and anti-inflammatory substances, as well as antiandrogens. "

03/01/2015 - "In this study the combination of a 5α-reductase inhibitor and (novel) antiandrogens synergistically inhibited tumor cell proliferation. "
02/01/1991 - " In vitro studies demonstrate that pure antiandrogens significantly inhibit about 60% of ovarian tumors. "
08/01/1980 - "[Fundamental and clinical study on antiandrogens--androgen-dependency of prostatic tumors and clinical application of antiandrogens (author's transl)]."
07/01/2015 - "The effects of non-steroidal antiandrogens on cancer-specific survival and biochemical progression remained unclear. "
01/01/2014 - "The effects of non-steroidal antiandrogens on cancer-specific survival and biochemical progression remained unclear. "

05/01/2005 - "Weight loss, oral contraceptives and antiandrogens are very effective in treating the symptoms of this disorder. "
03/01/2009 - "Weight loss, oral contraceptives, and antiandrogens are effective in treating the symptoms of this disorder. "
07/01/2002 - "A further clinical and endocrinological improvement can also be achieved by adding insulin-sensitizing agents and/or antiandrogens to weight reduction programmes. "
02/01/2004 - "Weight loss is beneficial, but the additional administration of insulin-lowering drugs, such as metformin, and antiandrogens may produce further benefits, due to their different spectrum of action. "
08/01/2003 - "Although oral contraceptives, progestins, antiandrogens, and ovulation induction agents remain standard therapies, weight loss should also be vigorously encouraged to ameliorate the metabolic consequences of PCOS. "