Anaplasia

05/01/2008 - "Histologically, KCM is similar to KA, with a central keratin-filled crater, overhanging lips of epithelium, a sharp outline between the tumour nests and stroma, and lack of anaplasia and stroma desmoplasia. "
11/01/2001 - "Ultrastructual features included cytokeratin filaments and desmosomes, as well as features of anaplasia (irregular cytoplasmic and nuclear margins, surface filopodia, and abnormal intermediate filament production). "
03/01/2006 - "The following features of the resected tumor were helpful for concluding that these acini were benign: lack of cytological anaplasia in spite of structural atypia, presence of scattered basal cells confirmed by immunohistochemistry (high-molecular-weight cytokeratin), and histological transition from these acini to apparently benign slit-like glands. "
08/01/1990 - "The changes of keratin fibers appeared to be parallel to the grade of histological anaplasia of the tumor formed by implantation of bladder carcinoma cell line cells to nude mice. "
03/01/1988 - "Six cases are reported (four gliosarcomas and two glioblastomas) in which the epithelial-like areas of glial anaplasia showed focal squamous cell differentiation, characterized by the development of epithelial whorls, keratin pearls and immunopositivity for cytokeratin. "

12/01/2008 - "All slides stained with hematoxylin and eosin were reviewed by two independent pathologists and all the diagnoses reconfirmed; histological anaplasia was classified according to the grading of the WHO Working Group 2000 as benign (Grade I), atypical with incipient signs of anaplasia (Grade II), or overtly anaplastic (Grade III). "
03/01/2022 - "Further, the hematoxylin staining intensity was significantly greater and that of eosin staining significantly lower in tumors with severe anaplasia (P < 0.05). "
07/01/2015 - "Hematoxylin and eosin stains showed nests of cells with eosinophilic cytoplasm separated by a hyalinized stroma, with no evidence of anaplasia or invasion, consistent with a Paraganglioma. "

12/01/2008 - "All slides stained with hematoxylin and eosin were reviewed by two independent pathologists and all the diagnoses reconfirmed; histological anaplasia was classified according to the grading of the WHO Working Group 2000 as benign (Grade I), atypical with incipient signs of anaplasia (Grade II), or overtly anaplastic (Grade III). "
03/01/2022 - "Further, the hematoxylin staining intensity was significantly greater and that of eosin staining significantly lower in tumors with severe anaplasia (P < 0.05). "
07/01/2015 - "Hematoxylin and eosin stains showed nests of cells with eosinophilic cytoplasm separated by a hyalinized stroma, with no evidence of anaplasia or invasion, consistent with a Paraganglioma. "

01/01/1983 - "No correlation was found between response to treatment with tamoxifen and disease free interval but a favourable connection was observed between good response and low grade of anaplasia of the tumor. "

10/01/1994 - "The addition of cyclophosphamide to the three-drug treatment regimen improved the 4-year relapse-free survival rate of children with stage II to IV diffuse anaplasia. "
10/01/1994 - "To evaluate the effect of the combination of vincristine, dactinomycin, and doxorubicin with (regimen J) or without (regimen DD-RT) cyclophosphamide on the relapse-free survival of children with stages II to IV Wilms' tumor and focal or diffuse anaplasia. "

11/09/2023 - "Interestingly, areas with wild-type TP53 with LOH and only one feature of anaplasia (anaplasia score 1) also had significantly higher proliferation indices, more DNA double strand breaks, and more CNAs than regions without any anaplastic features (score 0); such areas may be pre-anaplastic cell populations under selective pressure for TP53 mutations. "
11/09/2023 - "Proliferation index and the frequency of DNA double strand breaks (γH2AX dot expression) increased with higher anaplasia scores. "
01/01/2014 - "We studied 40 patients with DAWT with anaplasia in the tissue from which DNA was extracted and analysed for TP53 mutations and 17p loss. "
12/01/1996 - "The aim of the present work is therefore to investigate whether the quantitative description of morphonuclear features (including cell anaplasia) and the DNA ploidy level can contribute significant information to the Gleason grading, thus partly at least reducing its subjective nature. "
06/22/1979 - "The results demonstrate a correlation between the degree of cellular anaplasia and the occurrence of cell populations with increased DNA content in the tumours. "

07/31/2023 - "High risk (AOR = 3.42, 95% CI = 7.91-12.55, p = 0.037) and anaplasia (AOR = 1.41, 95% CI = 13.85-4.46, p = 0.001) were potential predictors of immunohistochemical expression of P53 protein. "
07/01/2001 - "No significant increase in p53 protein expression was noted in recurrences, even when associated with increased histological anaplasia. "
04/01/2000 - "Tumour immunoreactivity for this protein increases with the anaplasia of the tumour, as in some other tumours in which it is considered to play a role in drug resistance. "
01/01/1996 - "Immunohistochemical expression of p53 proteins in Wilms' tumour: a possible association with the histological prognostic parameter of anaplasia."
06/01/2018 - "The benign course, the well differentiated cells, absence of anaplasia and the positive reaction to Human Melanoma Black-45 (HMB-45) and S-100 proteins established the diagnosis of the former. "

10/01/1995 - "Enzyme expression decreases when the grade of anaplasia increases. "
02/01/1990 - "With the increasing anaplasia, there was a corresponding rise in the activity of the two enzymes. "
07/01/1973 - "[Oxidative-reductive enzymes and the phenomenon of anaplasia in neuroectodermal tumors (a histochemical study)]."
12/19/2022 - "The content of glutathione and the enzymes involved in its metabolism decreased with the increasing degree of glioma anaplasia. "
12/19/2022 - "Glutathione and Its Metabolic Enzymes in Gliomal Tumor Tissue and the Peritumoral Zone at Different Degrees of Anaplasia."

12/01/2002 - "Histologically, the lesion was composed of astrocytes and collagen-producing fibroblasts with no anaplasia. "
06/15/2007 - "The study included 74 adult patients with histologically confirmed medulloblastomas and retrospectively reassessed 67 cases with available slides for the presence of nodularity, collagen deposition (desmoplasia without nodules), and degree and extent of anaplasia. "
12/01/2015 - "Hence we suggest considering the integrity of extracellular matrix collagen, intactness of basement membrane and inflammation associated with dysplasia along with the anaplasia of epithelial cells in the microscopic assessment of dysplastic epithelium."
01/01/2003 - "In some areas, an abundance of keloidal collagen imparted a close resemblance to a solitary fibrous tumor, making it difficult to establish the diagnosis on the initial needle biopsy, although the malignant nature of the tumor was suggested because of nuclear anaplasia. "
07/01/1990 - "We have studied the ultrastructural distribution of GFAP, vimentin, FVIII/RAg and collagen IV in biopsies of human gliomas with various degree of anaplasia. "

06/01/1994 - "Sixty-six cases were investigated for the prognostic influence of estrogen (ER) and progesterone (PgR) status, mitotic activity, degree of nuclear anaplasia, and inflammatory reaction. "
08/12/1991 - "However, the prolongation is only significant in patients with four or more positive nodes, with tumours of less than 5 centimeters or with tumours of anaplasia grade II. Estrogen (ER) and progesterone receptor (PgR) concentrations were measured in tumours from 309 and 219 patients, respectively. "
01/01/1986 - "The 2 groups were identical with respect to age, tumor size, number of positive lymph nodes, degree of anaplasia, and estrogen and progesterone receptor content. "
01/01/1986 - "The TLI was negatively correlated with the age of the patient and content of estrogen and progesterone receptors and was positively correlated with the size of the carcinoma and the degrees of nuclear anaplasia, necrosis, and inflammatory cellular infiltrate. "
03/01/1990 - "Twelve factors were considered in the study; "age", "stage", "histological findings (structural atypism = SAT, nuclear anaplasia = NAN, Gleason's primary and secondary pattern)", "pretreatment level of total acid (ACP) and of alkaline phosphatase (ALP)", "castration performed or not performed", "doses of estrogen", "type of response of local prostatic tumor and of ACP to endocrine therapy". "

08/12/1978 - "Along with improved staging, histologic grading of the degree of anaplasia of the tumour tissue may permit more precise determination of prognosis and therefore better design of therapy. "
10/01/2006 - "We hypothesized that delay in diagnosis of anaplasia could affect time to appropriate surgery and intensive multimodality therapy. "
05/01/2004 - "In preoperatively treated WTs, anaplasia was a strong prognostic factor for death [relative risk (RR) 4.7], followed by poor response to preoperative therapy (RR 3.6), stage IV (RR 3.2) and abdominal stage III (RR 2.2). "
01/01/1997 - "Recent evidence suggests that anaplasia is a marker of resistance to adjuvant therapy, rather than increased aggressiveness. "
11/01/1996 - "The presence of gigantic nuclei with multipolar mitotic figures (anaplasia) appears to be a marker of resistance to therapy, but not of increased aggressiveness. "

05/01/2004 - "The main objective of the trial was the randomized question, if the postoperative two drug chemotherapy for stage I in intermediate risk or anaplasia can be reduced from conventional 3 courses to an experimental 1 course without loss of efficacy. "
01/01/2022 - "All cases had favorable histology with no anaplasia and received whole-brain irradiation and chemotherapy. "
08/01/2020 - "The histology report for the first case had more than 60% blastemal cells remaining despite giving pre-operative chemotherapy with no focal anaplasia. "
05/01/2011 - "The average number of days from the start of chemotherapy to diagnosis of anaplasia was 390 (range 44-1925 days). "
10/01/2006 - "The mean duration of first chemotherapy regimen (DD or EE) was 20, 39, and 36 weeks, respectively, before anaplasia was identified at second surgery. "

03/01/1990 - "Twelve factors were considered in the study; "age", "stage", "histological findings (structural atypism = SAT, nuclear anaplasia = NAN, Gleason's primary and secondary pattern)", "pretreatment level of total acid (ACP) and of alkaline phosphatase (ALP)", "castration performed or not performed", "doses of estrogen", "type of response of local prostatic tumor and of ACP to endocrine therapy". "

01/01/2020 - "Patients who had stage III or IV disease with favorable histology received radiotherapy as well as those who had stage I through IV anaplasia. "
04/01/2013 - "Histopathologically, the lesion was composed of spindle cells that manifested variable cellular anaplasia and expressed smooth muscle actin (SMA) and focally S-100.One of the resection limits was involved so patient was given post-operative radiotherapy. "
01/01/2013 - "Independent factors that influence the risk of recurrence are primary gross total resection, grade of anaplasia and radiation therapy. "
01/01/2008 - "30.04-19.11.2001--polychemotherapy according to the NWTS-5 stages 2-4 focal anaplasia and radiotherapy of the right kidney bed (29.06.2001). "
11/01/2010 - "Histological features of anaplasia including numerous mitoses, necrosis and high Ki-67 lead to postoperative adjuvant radiation therapy although gross total resection was achieved."

08/01/2018 - "Anaplasia was missed by CNB in one of three with diffuse anaplasia in nephrectomy specimens. "
01/01/2018 - "Submitted delayed nephrectomy histology showed anaplasia (n = 8; excluded from survival analysis); low risk/completely necrotic (n = 7; zero relapses), intermediate risk (n = 63; six relapses), and high-risk/blastemal type (n=7; five relapses). "
10/01/2006 - "Open biopsy or partial/complete nephrectomy identified anaplasia at initial diagnostic procedure in 10 of 18 children. "
06/01/2015 - "Pathologic results revealed positive surgical margins in 2 lesions with enucleation and in 2 with partial nephrectomies and anaplasia in 4 patients. "
05/01/2011 - "Anaplasia was diagnosed after completion of the initial course of chemotherapy in 14 patients (initial surgical procedure: 9 open biopsies, 4 needle biopsies, 1 partial nephrectomy). "