Analgesics (Analgesic Drugs)

07/01/2014 - "Most of the studies have demonstrated clinically significant reduction in pain intensity and supplemental analgesic requirement. "
01/01/1999 - "A key finding of these studies is that a report of pain relief may not be the best outcome measure since the choice of analgesic method(s) has a significant impact on the secondary effects of pain. "
02/01/1997 - "Knowledge of new novel classes of analgesics is important as further investigative studies will take place to determine which types of pain problems are most effectively treated by these classes of drugs."
01/01/2022 - "When combined with other analgesics commonly used in the spinal space, but not systemically, pain relief may be dramatically improved. "
01/01/2021 - "There is no consensus regarding which analgesic method is most effective in controlling pain in these children. "

01/01/2015 - "To run a systematic review and meta-analysis of randomized clinical trials aiming to answer the clinical question "which analgesic combination and dosage is potentially the most effective and safe for acute post-operative pain control after third molar surgery?". "
10/01/2010 - "The creative use of systemic analgesic techniques has dramatically improved the quality of postoperative pain management. "
06/01/2004 - "The post-operative pain level was relatively high, but a marked improvement was achieved in the course of the observation period by optimizing analgesic management."
09/14/2023 - "Results: The treatment group displayed a significant reduction in postoperative pain (mean difference = -1.7236 [-2.6825; -0.7646], I2 = 98.8%), as well as a significant decrease in both the amount (standardized mean difference = -2.4629 [-3.8042; -1.1216], I2 = 93.0%) and frequency (odds ratio = 0.3584 [0.1383; 0.9287], I2 = 59.7%) of analgesic medication use compared to the control. "
05/01/2022 - "Postoperative pain scores at rest and during swallowing were significantly lower in Group 1 versus Group 2. The analgesic efficacy of GNB was intensely interrelated with the magnitude of the obtunded gag reflex (P 0.01). "

11/01/2017 - "These findings share many similarities with those observed in neuropathic pain disorders and have important implications for treatment; adjuvant analgesics are effective in a subset of patients, and neuromodulation and neuropsychological interventions may prove useful in the future. "
07/01/2011 - "Although it shows analgesic efficacy against neuropathic pain, very limited evidence supports its postoperative analgesic efficacy. "
05/01/2009 - "Clinicians who treat neuropathic pain face daunting therapeutic challenges, but specific analgesic agents have proven effective in relieving that excruciating discomfort. "
12/01/1996 - "These results show that: 1) selective N-type VSCC blockers are potent and efficacious antinociceptive agents when they are administered by the spinal route; 2) selective N-type VSCC blockers are effective in rat models of acute, persistent and neuropathic pain; and 3) N-type VSCCs play a significant role in the spinal processing of noxious somatosensory input."
01/01/2022 - "Neuropathic pain is sometimes difficult to manage because of limited efficacy of analgesic monotherapy even at high doses. "

01/01/2022 - "Chronic pain is often refractory to most current analgesics, thus emphasizing the requirement for improved therapeutic medications. "
10/15/2013 - "In recent years, analgesics that target specific nAChR subtypes have shown highly efficacious antinociceptive properties in acute and chronic pain models. "
01/01/2020 - "The sEHI are multimodal analgesics that have demonstrated potent efficacy against chronic pain. "
01/01/2018 - "However, the analgesic effects are not associated with an improvement in functional recovery, clearly highlighting an important difference between the two serotypes for the treatment of this chronic pain state."
12/01/2017 - "Unfortunately, few patients with chronic pain obtain complete relief from the analgesics that are currently available. "

01/01/2022 - "Reply: Comparing analgesic efficacy of peripheral nerve blocks with thoracic epidural block after major abdominal cancer surgery: Study design is important."
01/01/2022 - "Comparing analgesic efficacy of peripheral nerve blocks with thoracic epidural block after major abdominal cancer surgery: Study design is important."
12/01/2007 - "Patients with pT2 tumors had significantly greater operating time, blood loss and analgesic requirements than pT1a/pT1b tumor patients. "
04/01/1989 - "When used correctly, analgesics are effective in a high percentage of cancer patients. "
05/01/2014 - "A safety investigation and comparison of the analgesic efficacy of ITM 0.2 mg, 0.5 mg, and 1 mg in patients undergoing major abdominal cancer surgery. "