Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Also Known As:

Analeptic Agents; Analeptic Drugs; Central Stimulants; Agent, Analeptic; Agents, Analeptic; Drug, Analeptic; Drugs, Analeptic; Stimulant, CNS; Stimulant, Central; Stimulants, CNS; Stimulants, Central; Analeptic; Analeptic Agent; Analeptic Drug; Analeptics; CNS Stimulant; CNS Stimulants; Central Nervous System Stimulant; Central Stimulant

Networked: 455 relevant articles (19 outcomes, 60 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Central Nervous System Agents: 51
      - Central Nervous System Stimulants: 455
        Convulsants: 881
        Aphrodisiacs: 194
        Appetite Stimulants: 79
        Wakefulness-Promoting Agents: 72
  - Physiological Effects of Drugs: 1
    - Central Nervous System Stimulants: 455

Experts

1.	Baweja, Raman: 5 articles (01/2022 - 03/2016)
2.	Waxmonsky, James G: 5 articles (01/2022 - 03/2016)
3.	Pelham, William E: 4 articles (01/2022 - 03/2016)
4.	Franck, Johan: 4 articles (02/2019 - 04/2010)
5.	Rasmussen, Kirsten: 4 articles (01/2019 - 01/2009)
6.	Nishino, Seiji: 4 articles (10/2011 - 02/2000)
7.	Ishikawa, Takaki: 3 articles (09/2022 - 08/2010)
8.	Waschbusch, Daniel A: 3 articles (01/2021 - 03/2016)
9.	Epps, Adrienne: 3 articles (01/2017 - 05/2013)
10.	McKinlay, Lynne: 3 articles (01/2017 - 05/2013)

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 07/01/2013 - "In the ADHD group, psychotherapeutic interventions were also associated with better outcome, but those who received treatment with central stimulants received less non-medical interventions. " 01/01/2019 - "Central nervous system stimulants are a commonly used first-line treatment option for attention-deficit/hyperactivity disorder (ADHD). " 11/10/2023 - "This study aims to investigate the factors influencing medication adherence among adults with Attention-Deficit/Hyperactivity Disorder (ADHD) and impact of central nervous system stimulants (CNS) adherence on healthcare utilization (HCU). " 01/01/2023 - "Salience and hedonic experience as predictors of central stimulant treatment response in ADHD - A resting state fMRI study." 01/01/2022 - "There were 230 medication-naïve children aged 5-12 years with ADHD who participated in a randomized trial evaluating the impact of CNS stimulants on growth over 30 months. "
2.	Narcolepsy 10/01/1998 - "In an ongoing attempt to develop a model to study the influence of various diseases and drugs on saliva, we studied persons with narcolepsy treated with central nervous system stimulants. " 10/01/1998 - "Both concentration and output of statherins and PRPs were increased in persons with narcolepsy receiving central nervous system stimulants compared with healthy control individuals. " 10/01/1998 - "Persons with narcolepsy treated with central nervous system stimulants only were included, n = 12, ages 14 to 68, seven females. " 10/01/1998 - "Salivary secretions: narcolepsy and central nervous system stimulants." 02/01/1998 - "Pharmacologic treatment of narcolepsy has depended on the use of CNS stimulants to increase wakefulness, vigilance, and performance. "
3.	Disorders of Excessive Somnolence (Hypersomnia) 09/01/1998 - "Untoward cardiovascular effects have been implicated as a deterrent to long-term central nervous system (CNS) stimulant use in disorders of hypersomnolence. " 11/28/1981 - "Treatment of hypersomnia with central stimulant drugs is often unsatisfactory, particularly in the elderly, and tracheostomy rather than medical treatment is sometimes essential in sleep apnoea." 05/01/1986 - "Treatment of hypersomnolence in myotonic dystrophy with a CNS stimulant." 07/01/2011 - "The objective of the study was to evaluate the efficacy of modafinil, a central stimulant, on excessive daytime sleepiness in children and adolescents with PWS. " 01/01/2020 - "The predictors of high OSA risk were use of mood stabilizers, use of CNS depressants, use of CNS stimulants, and excessive daytime sleepiness measured by ESS. "
4.	Cocaine-Related Disorders (Cocaine Addiction) 12/01/2007 - "Efficacy of central nervous system stimulant treatment for cocaine dependence: a systematic review and meta-analysis of randomized controlled clinical trials." 12/01/2007 - "To evaluate the efficacy of central nervous system (CNS) stimulants compared with placebo for the treatment of cocaine dependence. " 12/01/2007 - "The main outcomes of this study do not support the use of CNS stimulants for cocaine dependence. " 07/01/1996 - "The authors conducted an open-label trial of pemoline, a dopaminergic CNS stimulant, for the treatment of cocaine addiction in methadone-maintained patients. " 10/01/2000 - "Based on the evidence that orbitofrontal hyperactivity is also seen in cases of cocaine abuse, methylephedrine, which is a cocaine-like central nervous system stimulant, may play the main role in BRON dependence formation. "
5.	Cataplexy 01/01/1993 - "CNS stimulants are the most widely used drugs to treat narcolepsy which is characterized by the excessive daytime sleepiness and typically associated with cataplexy. " 05/08/2007 - "Excessive daytime sleepiness can be treated with central stimulants; cataplexy may be improved with an antidepressant. " 02/01/2000 - "Human narcolepsy is currently treated with central nervous system (CNS) stimulants for EDS and antidepressants for cataplexy and abnormal REM sleep. " 03/01/1991 - "Treatment of excessive daytime somnolence is still primarily based upon CNS stimulants, while treatment of cataplexy and related symptoms rests on antidepressants with a primarily serotonergic mode of action. " 01/01/1985 - "Treatment of excessive daytime somnolence is still primarily based upon CNS stimulants while treatment of cataplexy and other related symptoms rests on chlorimipramine. "

Related Drugs and Biologics

1.	Modafinil (Provigil)
2.	Methylphenidate (Ritalin)
3.	Amphetamine (Amfetamine)
4.	Analgesics (Analgesic Drugs)
5.	barbituric acid (barbiturate)
6.	Antidepressive Agents (Antidepressants)
7.	Opioid Analgesics (Opioids)
8.	Sympathomimetics (Sympathomimetic Amines)
9.	tartaric acid (tartrate)
10.	Dextroamphetamine (Dexedrine)

Related Therapies and Procedures

1.	Therapeutics
2.	Opiate Substitution Treatment
3.	Injections
4.	Drug Therapy (Chemotherapy)
5.	Hypnosis (Mesmerism)