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Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Also Known As:
Lou Gehrig's Disease; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Lou Gehrig Disease; Amyotrophic Lateral Sclerosis With Dementia; Amyotrophic Lateral Sclerosis, Guam Form; Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam; Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1; Charcot Disease; Dementia With Amyotrophic Lateral Sclerosis; Gehrig's Disease; Guam Disease; Guam Form of Amyotrophic Lateral Sclerosis; Lou-Gehrigs Disease; ALS Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1; Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam; Disease, Guam; Disease, Lou-Gehrigs; Gehrig Disease; Gehrigs Disease; Sclerosis, Amyotrophic Lateral; ALS - Amyotrophic Lateral Sclerosis
Networked: 12141 relevant articles (309 outcomes, 1286 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Alzheimer Disease (Alzheimer's Disease)
3. Neurodegenerative Diseases (Neurodegenerative Disease)
4. Huntington Disease (Huntington's Disease)
5. Multiple Sclerosis

Experts

1. Ludolph, Albert C: 91 articles (01/2022 - 10/2002)
2. Shaw, Pamela J: 77 articles (10/2022 - 06/2002)
3. Andersen, Peter M: 76 articles (11/2022 - 12/2002)
4. Brown, Robert H: 66 articles (01/2022 - 05/2002)
5. Silani, Vincenzo: 63 articles (01/2022 - 12/2002)
6. Sobue, Gen: 55 articles (02/2022 - 01/2002)
7. Trojanowski, John Q: 54 articles (10/2021 - 11/2004)
8. Al-Chalabi, Ammar: 53 articles (11/2022 - 12/2002)
9. Chiò, Adriano: 53 articles (11/2022 - 09/2004)
10. Petri, Susanne: 53 articles (11/2022 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Amyotrophic Lateral Sclerosis:
1. RiluzoleFDA LinkGeneric
2. Pharmaceutical PreparationsIBA
3. EdaravoneIBA
4. AntioxidantsIBA
5. Proteins (Proteins, Gene)FDA Link
6. LithiumIBA
7. Superoxide Dismutase-1IBA
8. Glutamic Acid (Glutamate)FDA Link
9. Neuroprotective AgentsIBA
10. MelatoninIBA

Therapies and Procedures

1. Therapeutics
2. Transplantation
3. Tracheostomy
4. Noninvasive Ventilation
5. Gastrostomy