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Serum Amyloid A Protein (Serum Amyloid A)

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An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.

Also Known As:

Serum Amyloid A; Amyloid A Protein; Amyloid A Precursor; Amyloid A Protein-Related Serum Component; Amyloid Fibril Protein AA; Amyloid Protein AA; Amyloid Protein AA Precursor; Amyloid-Related Serum Protein (SAA); Serum Amyloid Protein A; Amyloid A Protein Related Serum Component; Amyloid Protein SAA; Amyloid Serum Protein SAA; Serum A Related Protein

Networked: 1474 relevant articles (23 outcomes, 166 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Ray, Alpana: 13 articles (02/2015 - 02/2002)
2.	Ray, Bimal K: 12 articles (02/2015 - 02/2002)
3.	Schalkwijk, Casper G: 10 articles (03/2015 - 02/2011)
4.	Chait, Alan: 10 articles (01/2014 - 08/2004)
5.	Yamada, Toshiyuki: 9 articles (01/2014 - 06/2002)
6.	de Beer, Frederick C: 9 articles (01/2013 - 07/2002)
7.	Jacobsen, Stine: 8 articles (01/2016 - 04/2006)
8.	Bozinovski, Steven: 8 articles (02/2015 - 02/2008)
9.	Ulrich, Cornelia M: 8 articles (05/2014 - 03/2009)
10.	O'Brien, Kevin D: 8 articles (01/2014 - 08/2004)

Related Diseases

1.	Inflammation 09/01/2013 - "In the present study, we tested whether serum amyloid A (SAA) protein, an established biomarker of inflammation, also plays a role in stimulating neovascularization. " 07/01/2000 - "In this study, 232 lactating dairy cows from six herds were observed for clinical signs of inflammation and simultaneously had blood samples drawn to determine whether or not Serum Amyloid A (SAA) was present. " 12/01/2015 - "Emerging functions of serum amyloid A in inflammation." 09/01/2015 - "Serum amyloid A (SAA) is a family of protein that increases up to 1,000-fold in blood during inflammation. " 03/01/2015 - "Serum amyloid A (SAA) is increased by chronic inflammation, but SAA has not been previously evaluated as a potential DKD mediator. "
2.	Amyloidosis 10/01/2008 - "At the end of the study, a positive correlation was observed among the incidence and severity of amyloidosis, the serum amyloid A levels and the IL-1beta values both in the serum and tissues. " 09/25/1993 - "Most studies of experimental amyloid A protein (AA) amyloidosis in mice have been performed in type A mice with BALB/c as the prototype. " 08/01/1987 - "She had persistently increased concentration of serum amyloid A protein during the last 4 years of her life, and her amyloidosis was of the secondary (AA) type, as shown by immunohistochemical studies." 09/01/2015 - "Evidence has been provided on the presence of serum amyloid A (SAA) in several AKU tissues, which allowed classifying AKU as a novel secondary amyloidosis. " 07/01/2015 - "Involvement of the joint synovial membrane, that is capable of active serum amyloid A production, is the main predictor of renal amyloidosis in FMF. "
3.	Necrotizing Enterocolitis 08/01/2010 - "The purpose of this study was to evaluate the efficacy of serial serum amyloid A (SAA) measurements in diagnosis and follow-up of necrotizing enterocolitis (NEC) in preterm infants. " 08/01/2010 - "The efficacy of serial serum amyloid A measurements for diagnosis and follow-up of necrotizing enterocolitis in premature infants." 01/01/2014 - "Non-invasive serum amyloid A (SAA) measurement and plasma platelets for accurate prediction of surgical intervention in severe necrotizing enterocolitis (NEC)." 01/01/2011 - "We aimed to evaluate serum levels of serum amyloid-A (SAA) both in the diagnosis and monitoring the treatment response of necrotizing enterocolitis (NEC). " 01/01/2011 - "Serum amyloid-A levels in neonatal necrotizing enterocolitis."
4.	Proteinuria 07/01/2015 - "This treatment allowed to obtain amazing results: a rapid disappearance of any clinical symptoms, the stable normalization of serum amyloid-A and, furthermore, a marked improvement of glomerular filtration rate and proteinuria with no adverse events. " 12/01/2013 - "A follow-up should include clinical evaluation, therapeutic adjustments, measurement of serum amyloid A and proteinuria." 06/01/2011 - "Deposition of fibrils, derived from circulating acute-phase reactant serum amyloid A protein (SAA), in the kidneys can lead to proteinuria and progressive loss of renal function. " 08/01/1995 - "This drug suppresses the acute phase production of serum amyloid A protein, the precursor of AA amyloid fibrils, and is associated with remission of proteinuria and greatly improved survival. "
5.	Kidney Diseases (Kidney Disease) 12/15/2013 - "The results indicate that IRCT with serum amyloid A-positive cells is effective in preventing the progression of chronic kidney disease in rats with diabetic and ischemic nephropathy. " 09/01/2014 - "Moreover, serum amyloid A (P = 0.020), alpha2-globulin (P < 0.001) and haptoglobin (P = 0.001) concentrations in cheetahs suffering from chronic kidney disease were significantly greater compared to the reportedly healthy cheetahs. "

Related Drugs and Biologics

1.	C-Reactive Protein
2.	Haptoglobins
3.	Cholesterol
4.	Prednisolone (Predate)
5.	Interleukin-6 (Interleukin 6)
6.	Acute-Phase Proteins (Acute-Phase Protein)
7.	Fibrinogen (Factor I)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Interleukins
10.	procalcitonin

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)
2.	Angioplasty (Angioplasty, Transluminal)
3.	Stents
4.	Hepatectomy
5.	Renal Dialysis (Hemodialysis)