Ampicillin (Omnipen)

Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.

Also Known As:

Omnipen; Polycillin; Amcill; Aminobenzylpenicillin; Ampicillin Sodium; Ampicillin Trihydrate; Antibiotic KS-R1; Pentrexyl; Ukapen; Aminobenzyl Penicillin; Antibiotic KS R1; KS-R1, Antibiotic; Sodium, Ampicillin; Trihydrate, Ampicillin; Penicillin, Aminobenzyl; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-

Networked: 4218 relevant articles (421 outcomes, 416 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sakamoto, Naoya: 10 articles (01/2019 - 07/2010)
2.	Oue, Naohide: 9 articles (02/2017 - 07/2010)
3.	Sentani, Kazuhiro: 9 articles (02/2017 - 07/2010)
4.	Yasui, Wataru: 9 articles (02/2017 - 07/2010)
5.	Kohno, Shigeru: 8 articles (03/2015 - 01/2006)
6.	Sunakawa, Keisuke: 8 articles (08/2013 - 05/2004)
7.	Ubukata, Kimiko: 8 articles (08/2013 - 05/2004)
8.	Sharland, Mike: 6 articles (01/2022 - 06/2018)
9.	Arias, Cesar A: 6 articles (01/2020 - 11/2007)
10.	Anami, Katsuhiro: 6 articles (04/2016 - 07/2010)

Related Diseases

1.	Infections 07/01/1981 - "Ampicillin given at the time of maximum bacterial growth at 24 hr caused a striking reduction in the number of protective T cells produced at the time of peak response on day 6. Although the greatest effect was caused by giving ampicillin early in infection, a significant reduction in peak T cell production occurred even when Ampicillin was given as late as day 5. On the other hand, the effect of abridging infection at the onset of decay of the anti-Listeria response was to cause protective T cells to be lost from the spleen at a much faster rate. " 05/01/1994 - "Single intra-abdominal administration of sodium ampicillin during surgery provides good protection against infection without negative effects on the postoperative performance." 04/01/1997 - "From the data, treatment with ampicillin is recommended, with resort to surgery in cases where the infection cannot be eradicated or where haemodynamic compromise has occurred." 01/01/2020 - "hydrophila infection in vivo, and enhanced the therapeutic efficacy of ampicillin against A. " 01/01/2017 - "Although ampicillin is often effective for systemic enterococcal infections, they have little in vitro activity when added to common PD solutions. "
2.	Endocarditis 01/01/1984 - "Ampicillin is effective in endocarditis due to Haemophilus influenzae, H. " 03/01/2023 - "ginseng and ampicillin treatment in an animal model of Listeria monocytogenes-induced endocarditis. " 03/01/2023 - "Effect of hydro-alcoholic extract of Panax ginseng and Ampicillin treatment in an animal model of Listeria monocytogenes-induced endocarditis." 06/01/2020 - "Continuous Infusion Ampicillin for the Outpatient Management of Enterococcal Endocarditis: A Case Report and Literature Review." 06/01/2013 - "Ampicillin (parenteral): prevention of infective endocarditis."
3.	Meningitis 01/01/1991 - "We have demonstrated that the serum and cerebrospinal fluid concentrations of ampicillin and its efficacy when used in the treatment of meningitis are comparable whether they are administered intravenously or intramuscularly. " 08/01/1979 - "By comparison, 7 of 10 children with meningitis responded optimally to ampicillin (nonrandomized design) during the period of study. " 12/01/1964 - "INFLUENZAE MENINGITIS: A CONTROLLED STUDY OF TREATMENT WITH AMPICILLIN." 01/01/2023 - "β-lactamase nonproducing ampicillin-resistant Haemophilus influenzae type f meningitis in an infant." 05/01/2019 - "50 Years Ago in The Journal of Pediatrics: Ampicillin in the Treatment of Meningitis due to Haemophilus influenzae: An Appraisal after 6 Years of Experience."
4.	Pneumonia (Pneumonitis) 05/01/2014 - "Ampicillin treatment cured mice with mild pneumonia but was ineffective against severely pneumonic mice, despite effective bacterial killing. " 01/01/1992 - "The compound was found to be effective against the pneumonia in combination with subcutaneous ampicillin (ABPC). " 04/20/2021 - "This study highlights the effectiveness of ampicillin monotherapy in the treatment of community-acquired pneumonia in hospitalized children in a non-intensive care unit setting." 12/09/1972 - "A controlled trial was carried out to investigate whether the rate of recovery from pneumonia treated with ampicillin is dose related. " 01/01/2016 - "pneumonia reveals the ampicillin-sensitive feature relative to the wild type strain. "
5.	Sepsis (Septicemia) 09/01/1985 - "A case of successful therapy with ampicillin of maternal septicemia due to Listeria monocytogenes at 26 weeks' gestation with resultant delivery at term of a normal neonate is reported. " 01/01/2020 - "For total early onset non-GBS sepsis (non-GBS-EOS), 7 studies with low heterogeneity (I = 18%) had a pooled RR of 0.91 (95% CI: 0.74-1.11), whereas for ampicillin resistant Escherichia coli-EOS, a subgroup of non-GBS-EOS, 3 studies with very low heterogeneity (I = 0%) had a pooled RR of 1.28 (95% CI: 0.74-2.21) for screening-based strategy compared with risk-based strategy. " 01/01/2020 - "We identified infants <28 days of age with Escherichia coli, Enterococcus or Streptococcus agalactiae (group B streptococcus) bloodstream infections from 1997 to 2012 and previously included in an ampicillin pharmacokinetic (PK) modeling study. " 02/28/2015 - "This is the first study to describe bloodstream infections caused by ampicillin-resistant HLGR E. " 01/01/2023 - "faecalis bloodstream infections in which ampicillin serum concentrations were measured. "

Related Drugs and Biologics

1.	Sulbactam
2.	Gentamicins (Gentamicin)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Chloramphenicol (Chloromycetin)
5.	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)
6.	Ceftriaxone (Ceftriaxon)
7.	Amoxicillin (Wymox)
8.	Vancomycin
9.	Penicillins (Penicillin)
10.	Ciprofloxacin (Cipro)

Related Therapies and Procedures

1.	Therapeutics
2.	Catheters
3.	Injections
4.	Chemoprevention
5.	Hysterectomy