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Amobarbital (Amsal)

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A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)

Also Known As:

Amsal; Adams Brand of Amobarbital Sodium; Adams Brand of Amorbarbital; Amobarbital Sodium; Amylbarb sodium; Amylobeta; Amytal; Amytal Sodium; Barbamyl; Bramble Brand of Amobarbital Sodium; Eunoctal; Fawns & McAllan Brand of Amorbarbital; Flynn Brand of Amobarbital; Flynn Brand of Amobarbital Sodium; Hosbon Brand of Amorbarbital; Houdé Brand of Amobarbital Sodium; ICN Brand of Amorbarbital; Isoamitil Sedante; Isonal; Lilly Brand of Amobarbital; Lilly Brand of Amobarbital Sodium; Miquel Brand of Amorbarbital; Neur-Amyl; Novamobarb; Novopharm Brand of Amobarbital Sodium; Placidel; Protea Brand of Amobarbital Sodium; Sodium Amobarbital; Sodium Amytal; Transital; Amobarbital, Sodium; Amorbarbital Miquel Brand; NeurAmyl; Sodium, Amobarbital; Amylobarbitone; Pentymal; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(3-methylbutyl)-

Networked: 446 relevant articles (14 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lesnefsky, Edward J: 7 articles (06/2013 - 01/2006)
2.	Chen, Qun: 7 articles (06/2013 - 01/2006)
3.	Vonck, K: 4 articles (03/2006 - 08/2002)
4.	Smith, Mary Lou: 3 articles (10/2013 - 01/2003)
5.	Swanson, Sara J: 3 articles (07/2013 - 12/2007)
6.	Sabsevitz, David S: 3 articles (07/2013 - 12/2007)
7.	Binder, Jeffrey R: 3 articles (07/2013 - 12/2007)
8.	Lee, Gregory P: 3 articles (06/2009 - 09/2002)
9.	Pauli, E: 3 articles (07/2008 - 08/2000)
10.	Hoppel, Charles L: 3 articles (02/2008 - 01/2006)

Related Diseases

1.	Epilepsy (Aura) 03/01/2007 - "The intracarotid amobarbital procedure or Wada test has been the gold standard for lateralization of language dominance before epilepsy surgery. " 02/01/2010 - "In this study of epilepsy patients with unambiguous lateralization on Wada testing (19 left and 4 right lateralized subjects; no bilateral subjects), the predictive value of DTI for classifying the dominant hemisphere for language was assessed relative to the existing standard-the intra-carotid Amytal (Wada) procedure. " 09/01/2009 - "The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure. " 05/01/2006 - "The present study investigates this issue by measuring the volume of the PT and HG on the MRI scans of epilepsy patients classified into three groups: left speech group (LSG; n = 20), right speech group (RSG; n = 11) and bilateral speech group (BSG; n = 13), as assessed by the intracarotid Sodium Amytal procedure. " 02/01/2001 - "This study evaluated the validity of data derived from magnetic source imaging regarding hemispheric dominance for language in children and adolescents with intractable seizure disorder by comparison with results of the intracarotid amobarbital procedure. "
2.	Sleep Initiation and Maintenance Disorders (Insomnia) 06/01/1979 - "3. Diazepam improved significantly subjective anxiety and insomnia, while amylobarbitone improved only the self-rated quality of sleep. " 01/01/1979 - "2. Self rated anxiety and insomnia were improved significantly by diazepam, while amylobarbitone improved only the self rated insomnia. " 01/01/1983 - "Lormetazepam and amobarbital were equivalent in the amount of time it took patients receiving each drug to fall asleep and in the duration of the patients' sleep, but insomnia disappeared (or the condition improved) in a larger proportion of patients receiving lormetazepam, and there were fewer adverse effects (eg, hangover in the morning, sedation in the morning and during the day, and dry mouth) in patients receiving lormetazepam than in patients receiving amobarbital." 01/01/1983 - "Lormetazepam and amobarbital sodium in the outpatient treatment of insomnia: a controlled trial." 01/01/1983 - "In a double-blind clinical trial, 50 psychiatric outpatients with moderate insomnia (requiring daily treatment with a hypnotic drug) were treated for two weeks with lormetazepam (1 mg) or amobarbital sodium (100 mg). "
3.	Seizures (Seizure) 04/01/2006 - "Preoperative evaluation included a routine and video-electroencephalography recordings, magnetic resonance imaging of the head according to the seizure protocol, neuropsychological testing, and a sodium amobarbital study. " 01/01/2003 - "The purpose of this study was to investigate the relationship between hemispheric speech dominance and several demographic and seizure variables in a large sample of children (N=75) who underwent the intracarotid amobarbital procedure (IAP) prior to surgery. " 11/01/2000 - "Patients were studied by simultaneous videotape and scalp electroencephalographic recording of typical seizures; magnetic resonance imaging; neuropsychologic studies; and, when appropriate, intracarotid amobarbital testing. " 03/01/1997 - "We used a protocol consisting of a continuous presentation of stimuli with associated response requests during an intracarotid sodium amobarbital procedure (IAP) to study the effects of hemisphere injected (speech dominant vs. nondominant) and seizure focus (left temporal lobe vs. right temporal lobe) on the pattern of behavioral response errors for three types of visual stimuli (pictures of common objects, words, and abstract forms). " 11/01/1992 - "Interhemispheric dissociation of expressive and receptive language functions in patients with complex-partial seizures: an amobarbital study."
4.	Pain (Aches) 12/01/2003 - "Intravenous sodium amytal improved the posture, pain or both in 13 of 13 patients; in 7 of 13 the sensory deficit either markedly improved or normalized. " 03/01/1998 - "A 50-mg dose of intravenous amobarbital, which produced a plasma concentration of 2.5-4.0 microg/ml, was effective in reducing the central pain. " 01/01/1978 - "The author suggests that sodium amytal helps to overcome language barriers, reduces the time required for proper assessment and allows the patient and the examiner to appreciate more precisely, the level of pain and the limits of physical performance as well as permitting an effective exploration of important psychodynamic issues." 01/01/1978 - "Sodium amytal in the diagnosis of chronic pain." 09/27/1963 - "FEAR AND PAIN: THEIR EFFECT ON SELF-INJECTION OF AMOBARBITAL SODIUM BY RATS."
5.	Mutism (Selective Mutism) 02/01/1992 - "Intravenous amobarbital is superior to saline in relieving catatonic mutism, although only 50% of these patients responded. " 11/01/1992 - "A clinical case of mutism is described in this research to illustrate the usefulness of the amytal interview. " 11/01/1992 - "Although the amobarbital interview is an effective means of temporarily relieving catatonic mutism, some catatonic patients simply fall asleep during an amobarbital interview. " 02/01/1992 - "The authors postulated that a randomized blind comparison of intravenous amobarbital and saline would demonstrate the superiority of amobarbital in relieving catatonic mutism. " 02/01/1992 - "Controlled investigation of the amobarbital interview for catatonic mutism."

Related Drugs and Biologics

1.	Diazepam (Valium)
2.	barbituric acid (barbiturate)
3.	lormetazepam
4.	Paraldehyde
5.	Methylphenidate (Ritalin)
6.	Sodium
7.	Secobarbital (Sebar)
8.	Phenobarbital (Luminal)
9.	Methohexital (Brevital)
10.	Lidocaine (Xylocaine)

Related Therapies and Procedures

1.	Anterior Temporal Lobectomy
2.	Injections
3.	Hemispherectomy
4.	Surgical Equipment
5.	Anesthesia