Ammonium Chloride (Sal Ammoniac)

01/01/1997 - "Mutant viruses produced greater yields than the parental wild-type (wt) strains in MEL cells cured of persistent infection and in cells treated with ammonium chloride, a weak base that blocks viral disassembly. "
01/01/2001 - "In this study we have demonstrated that recombinant viruses carrying the amino acid mutations Q1067H, Q1094H, and L1114R were unable to induce fusion at neutral pH, replicated more efficiently in L2 cells, and that infection was delayed by ammonium chloride. "
10/01/1999 - "Study of prophylaxis by didecyl dimethyl ammonium chloride against herpes simplex virus infection in nude mice."
01/01/2015 - "After uptake, DENV-3 transits through early endosomes to reach Rab 7-regulated late endosomes, and according with the half-time for ammonium chloride resistance viral nucleocapsid is released into the cytosol approximately at 12 min post-infection. "
01/01/2014 - "While all three agents inhibited CHIKV infection in C6/36 cells, ammonium chloride was less toxic to cells than the other agents. "

07/01/1993 - "In eight male subjects acidosis was induced by ingesting 0.3 g.kg-1 ammonium chloride (AC) for one trial, by upper body exercise (UBE) for another trial, and after placebo (PL) treatment. "
08/01/1990 - "During studies performed on domestic cats made acidotic with ammonium chloride, it was found that the cat kidney is unable to adapt to metabolic acidosis. "
08/01/1982 - "Renal adaptation to chronic metabolic acidosis was studies in Arbor Acre hens receiving ammonium chloride by stomach tube 0.75 g/kg/day during 6 days. "
12/01/2012 - "Blood gas analysis revealed normal anion gap metabolic acidosis with a urine pH of 7. Ammonium chloride (NH4CL) challenge test revealed proximal tubular acidosis. "
09/01/2012 - "To test the effect of NO donors on the Na⁺/H⁺ exchanger (NHE), basal pH(i) in Na⁺-free buffer and pH(i) recovery from intracellular acidosis after an ammonium chloride (10 mmol/L) prepulse were monitored. "

09/01/1987 - "Urinary pH was 7.5 in controls compared with approximately 7.2 in rats given the subprophylactic level of ammonium chloride, but ammonium chloride alone had no effect on urolithiasis. "
05/01/1989 - "Urinary acidification previously was shown to be an effective treatment for calcium-induced urolithiasis in domestic fowl, but diuresis caused by the acidifying agent (ammonium chloride) was an undesirable side effect. "
11/18/2011 - "The efficacy of 125, 250, and 500 mg/kg HP extract was studied in 1% ethylene glycol and 1% ammonium chloride-induced urolithiasis for 21 days in rats. "
12/01/2010 - "Further studies of ammonium chloride supplementation and urolithiasis in goats fed low-calcium diets are indicated."
07/01/2014 - "Urolithiasis was induced by supplying drinking water mixed with 2% Ammonium chloride and 0.75% Ethylene glycol for 10 days. "

02/01/1994 - "Ammonium chloride stimulated TAU release in a dose-dependent manner, a significant stimulation being already observed at 0.5 mM, a concentration that is frequently measured in brain during acute hyperammonemia. "
12/01/1991 - "All the experimental conditions affected the nonsynaptic mitochondria PC: ammonium chloride in vitro produced a 20% decrease, TAA-induced HE--a 30% decrease, whereas hyperammonemia inhibited the enzyme by 53%. "
01/01/2006 - "The present investigation was designed to study the protective role of Pongamia pinnata (an indigenous plant used in Ayurvedic medicine in India) leaf extract on oxidative stress during ammonium chloride-induced hyperammonemia by measuring the extent of oxidative damage as well as antioxidant status. "
06/01/1990 - "Hyperammonemia was induced via administration of ammonium chloride (NH4Cl; 12 mumol.kg BW-1.min-1) via the femoral vein catheter for 240 min; infusions were preceded (PRE) and followed (POST) by 60- and 180-min control periods, respectively. "
07/01/2013 - "Hyperammonemia was induced in male rats by daily intraperitoneal (i.p.) injection of ammonium chloride (100 mg/kg body weight) for 8 weeks. "

01/01/2012 - "The use of ammonium chloride injection administered enterally was a safe and effective option in 2 of the 3 pediatric patients with persistent metabolic alkalosis."
01/01/1986 - "In this study the effects of ammonium chloride, an agent clinically used for the correction of severe metabolic alkalosis, were studied on the extra- and intracellular acid-base balance of nephrectomized rats. "
01/01/2012 - "Two of the 3 patients achieved resolution of metabolic alkalosis with ammonium chloride, while 1 patient's condition was refractory to treatment. "
01/01/2012 - "This case series describes 3 pediatric patients who received ammonium chloride enterally for the treatment of persistent metabolic alkalosis. "
05/01/1979 - "Ammonium chloride should be abandoned as a treatment for metabolic alkalosis."