Amiodarone (Amiodarona)

An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.

Also Known As:

Amiodarona; Cordarone; L 3428; Amiobeta; Amiodarex; Amiodarone Hydrochloride; Amiohexal; Aratac; Braxan; Corbionax; Cordarex; Kordaron; L-3428; Ortacrone; Rytmarone; SKF 33134-A; Tachydaron; Trangorex; Hydrochloride, Amiodarone; L3428; SKF 33134 A; SKF 33134A; Methanone, (2-butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)-

Networked: 5641 relevant articles (606 outcomes, 863 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Dorian, Paul: 28 articles (10/2022 - 03/2002)
2.	Bogazzi, Fausto: 27 articles (01/2023 - 01/2002)
3.	White, C Michael: 23 articles (09/2017 - 01/2002)
4.	Bartalena, Luigi: 22 articles (01/2023 - 01/2002)
5.	Martino, Enio: 22 articles (01/2020 - 01/2002)
6.	Kluger, Jeffrey: 19 articles (08/2013 - 01/2002)
7.	Singh, Bramah N: 16 articles (12/2010 - 04/2002)
8.	Bardy, Gust H: 14 articles (01/2020 - 01/2005)
9.	Anderson, Jill: 13 articles (01/2020 - 01/2005)
10.	Lee, Kerry L: 13 articles (01/2020 - 01/2005)

Related Diseases

1.	Atrial Fibrillation 01/01/1985 - "Intravenous amiodarone appears as a highly effective medication in the conversion or control of new onset atrial fibrillation with fast ventricular response." 07/01/1980 - "Fifteen have been controlled with amiodarone, this treatment proving most effective in atrial fibrillation or flutter with or without pre-excitation. " 02/01/2013 - "Multiple studies have shown that amiodarone is effective in treating atrial fibrillation (AF), but is associated with a relatively high incidence of side effects; however, due to amiodarone's long elimination half-life (20-100 days), physicians may hesitate to start other drugs until it has fully cleared. " 07/01/2007 - "Good results have been obtained with a human amiodarone (AD) i.v. protocol in horses with chronic atrial fibrillation (AF) and a pharmacokinetic study is required for a specific i.v. amiodarone treatment protocol for horses. " 01/01/2013 - "Shown that the VFS is more effective than amiodarone, both in paroxysmal atrial fibrillation and ventricular arrhythmias when high gradation. "
2.	Ventricular Tachycardia 07/01/2019 - "The most effective treatment for the prevention of recurrent ventricular tachycardia after ICD is amiodarone followed by CA. Amiodarone is most effective in the reduction of appropriate and inappropriate ICD shocks with an odds ratio (OR) of 0.29 [95% confidence interval (CI), 0.11-0.74] and 0.15 (95% CI, 0.04-0.60), respectively. " 04/14/2018 - "Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury. " 12/01/1995 - "After several days of loading, oral amiodarone, a class III antiarrhythmic, is highly effective in controlling ventricular tachyarrhythmias; however, the delay in onset of activity is not acceptable in patients with immediately life-threatening arrhythmias. " 12/01/1991 - "Intravenous amiodarone is very effective in preventing arrhythmic deaths in patients with refractory ventricular tachycardia and fibrillation." 06/01/1991 - "Amiodarone is very effective in suppressing refractory nonsustained ventricular tachycardia. "
3.	Cardiac Arrhythmias (Arrythmia) 11/01/2018 - "Amiodarone was highly effective when tolerated, however, achieving complete arrhythmia control in 63%, partial control in 35%, with failure to control in only one patient. " 12/01/2000 - "The present analysis was performed to obtain the most precise estimate of the efficacy of the ICD, compared to amiodarone, for prolonging survival in patients with malignant ventricular arrhythmia. " 05/01/1997 - "The objectives of this review were to summarize what is known about intravenous amiodarone, including its pharmacologic and electrophysiologic effects, to review its efficacy for the treatment of patients with highly malignant ventricular arrhythmia and to provide specific information about its clinical use for this and other indications. " 12/15/1983 - "Digitalis + amiodarone is the best treatment, though the arrhythmia may resolve spontaneously." 10/01/1983 - "The clinical utility of electrophysiologic testing in assessing the long-term efficacy of amiodarone for treatment of life-threatening ventricular arrhythmias is controversial, most investigators reporting little or no correlation between the early effects of the drug on arrhythmia inducibility and subsequent prognosis. "
4.	Tachycardia (Tachyarrhythmias) 04/01/2001 - "Antiarrhythmic agents with amiodarone-like electrophysiological actions, but with a more favorable pharmacokinetic profile than amiodarone would be extremely useful for the treatment of many tachyarrhythmias. " 12/01/1997 - "Amiodarone is highly effective in suppressing ventricular and supraventricular tachyarrhythmias. " 04/01/1996 - "Intravenous amiodarone is safe and effective in most young patients with critical tachyarrhythmia. " 01/01/1992 - "In the present case, as in the others reported in the literature, the drug of choice seems to be Amiodarone which appears to be the most effective in preventing tachyarrhythmias caused by swallowing." 12/28/2005 - "To determine whether a brief perioperative course of oral amiodarone is an effective and safe prophylaxis for atrial tachyarrhythmias after cardiac surgery overall and in important subgroups. "
5.	Heart Failure 08/01/2022 - "Amiodarone is a highly effective treatment for life-threatening supraventricular and ventricular arrhythmias, namely in the setting of acutely decompensated heart failure. " 11/01/2008 - "Historically, amiodarone has proved most effective in maintaining sinus rhythm and has been used safely in patients with advanced heart failure. " 01/01/2007 - "Amiodarone is potentially effective for preventing VT/VF in patients at high risk, especially those with nonischemic heart failure. " 08/01/2000 - "Amiodarone may be beneficial in patients with advanced heart failure and increased resting heart rates. " 09/01/1997 - "Amiodarone may be beneficial in patients with advanced heart failure and rapid resting heart rates. "

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5.	Digoxin (Digitek)
6.	Flecainide (Tambocor)
7.	Dronedarone
8.	Quinidine (Chinidin)
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Related Therapies and Procedures

1.	Therapeutics
2.	Electric Countershock (Cardioversion)
3.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
5.	Resuscitation