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Amiodarone (Amiodarona)

An antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance.

Also Known As:

Amiodarona; Cordarone; L 3428; ASTA Medica Brand of Amiodarone Hydrochloride; Alphapharm Brand of Amiodarone Hydrochloride; Amiobeta; Amiodarex; Amiohexal; Aratac; Armstrong Brand of Amiodarone Hydrochloride; Berenguer Infale Brand of Amiodarone Hydrochloride; Betapharm Brand of Amiodarone Hydrochloride; Braxan; Corbionax; Cordarex; G Gam Brand of Amiodarone Hydrochloride; Hexal Brand of Amiodarone Hydrochloride; Kordaron; L-3428; Leurquin Brand of Amiodarone Hydrochloride; Ortacrone; Pharma Investi Brand of Amiodarone Hydrochloride; Rytmarone; SKF 33134-A; Sanofi Winthrop Brand of Amiodarone Hydrochloride; Tachydaron; Trangorex; Wyeth Brand of Amiodarone Hydrochloride; L3428; SKF 33134 A; SKF 33134A; Methanone, (2-butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)-

Networked: 4212 relevant articles (479 outcomes, 645 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Benzofurans: 12
    - Amiodarone: 4212

Experts

1.	White, C Michael: 22 articles (04/2008 - 01/2002)
2.	Dorian, Paul: 20 articles (09/2015 - 03/2002)
3.	Martino, Enio: 19 articles (09/2014 - 01/2002)
4.	Kluger, Jeffrey: 19 articles (08/2013 - 01/2002)
5.	Bartalena, Luigi: 17 articles (01/2015 - 01/2002)
6.	Bogazzi, Fausto: 17 articles (09/2014 - 01/2002)
7.	Singh, Bramah N: 16 articles (12/2010 - 04/2002)
8.	Bardy, Gust H: 13 articles (06/2014 - 01/2005)
9.	Anderson, Jill: 12 articles (06/2014 - 01/2005)
10.	Mark, Daniel B: 12 articles (06/2014 - 01/2005)

Related Diseases

1.	Atrial Fibrillation 01/01/1985 - "Intravenous amiodarone appears as a highly effective medication in the conversion or control of new onset atrial fibrillation with fast ventricular response." 07/01/1980 - "Fifteen have been controlled with amiodarone, this treatment proving most effective in atrial fibrillation or flutter with or without pre-excitation. " 02/01/2013 - "Multiple studies have shown that amiodarone is effective in treating atrial fibrillation (AF), but is associated with a relatively high incidence of side effects; however, due to amiodarone's long elimination half-life (20-100 days), physicians may hesitate to start other drugs until it has fully cleared. " 07/01/2007 - "Good results have been obtained with a human amiodarone (AD) i.v. protocol in horses with chronic atrial fibrillation (AF) and a pharmacokinetic study is required for a specific i.v. amiodarone treatment protocol for horses. " 01/01/2013 - "Shown that the VFS is more effective than amiodarone, both in paroxysmal atrial fibrillation and ventricular arrhythmias when high gradation. "
2.	Cardiac Arrhythmias (Arrythmia) 12/01/2000 - "The present analysis was performed to obtain the most precise estimate of the efficacy of the ICD, compared to amiodarone, for prolonging survival in patients with malignant ventricular arrhythmia. " 05/01/1997 - "The objectives of this review were to summarize what is known about intravenous amiodarone, including its pharmacologic and electrophysiologic effects, to review its efficacy for the treatment of patients with highly malignant ventricular arrhythmia and to provide specific information about its clinical use for this and other indications. " 11/01/1985 - "We conclude that amiodarone is highly effective in the management of high-risk patients with complex refractory cardiac arrhythmias and that close monitoring and prompt recognition of side effects and appropriate adjustment of dosage or institution of supplemental or replacement therapy (in less than 5% of patients) will allow continuation of amiodarone. " 12/15/1983 - "Digitalis + amiodarone is the best treatment, though the arrhythmia may resolve spontaneously." 10/01/1983 - "We conclude that amiodarone is highly effective in high-risk patients with complex refractory cardiac arrhythmias, and that close monitoring and prompt recognition of side effects and appropriate adjustment of dosage or institution of supplemental or replacement therapy (in less than 5% of patients) will allow continuation of amiodarone. "
3.	Ventricular Tachycardia 12/01/1991 - "Intravenous amiodarone is very effective in preventing arrhythmic deaths in patients with refractory ventricular tachycardia and fibrillation." 06/01/1991 - "Amiodarone is very effective in suppressing refractory nonsustained ventricular tachycardia. " 08/01/2013 - "There was a significant reduction in the incidence of ventricular tachycardia/fibrillation episodes (median 2 vs. 12 events, P = 0.001) and shocks (median 0 vs. 2 events, P = 0.003) in the first 3 months of treatment, but long-term efficacy was only observed among patients who continued amiodarone therapy. " 03/01/1988 - "In the adult the finding of nonsustained ventricular tachycardia on electrocardiographic monitoring is a sensitive and specific marker of high risk and treatment of such patients with low-dose amiodarone is associated with improved survival. " 01/01/1988 - "Thus although we found intravenous amiodarone to be effective in the short-term treatment of refractory ventricular tachycardia, administration of amiodarone can be associated with significant hemodynamic deterioration. "
4.	Tachycardia (Tachyarrhythmias) 04/01/2001 - "Antiarrhythmic agents with amiodarone-like electrophysiological actions, but with a more favorable pharmacokinetic profile than amiodarone would be extremely useful for the treatment of many tachyarrhythmias. " 12/01/1997 - "Amiodarone is highly effective in suppressing ventricular and supraventricular tachyarrhythmias. " 04/01/1996 - "Intravenous amiodarone is safe and effective in most young patients with critical tachyarrhythmia. " 12/01/1995 - "After several days of loading, oral amiodarone, a class III antiarrhythmic, is highly effective in controlling ventricular tachyarrhythmias; however, the delay in onset of activity is not acceptable in patients with immediately life-threatening arrhythmias. " 01/01/1992 - "In the present case, as in the others reported in the literature, the drug of choice seems to be Amiodarone which appears to be the most effective in preventing tachyarrhythmias caused by swallowing."
5.	Heart Failure 11/01/2008 - "Historically, amiodarone has proved most effective in maintaining sinus rhythm and has been used safely in patients with advanced heart failure. " 01/01/2007 - "Amiodarone is potentially effective for preventing VT/VF in patients at high risk, especially those with nonischemic heart failure. " 09/01/1997 - "Amiodarone may be beneficial in patients with advanced heart failure and rapid resting heart rates. " 05/01/1997 - "Amiodarone may be beneficial in patients with advanced heart failure and rapid resting heart rates. " 08/01/1997 - "Data also suggest that amiodarone appears to be the safest antiarrhythmic drug for treatment sustained and nonsustained arrhythmias, and improved survival in patients with advanced heart failure."

Related Drugs and Biologics

1.	Sotalol (Sotalol Hydrochloride)
2.	Anti-Arrhythmia Agents
3.	Propafenone (Rythmol)
4.	Flecainide (Tambocor)
5.	Digoxin (Digitek)
6.	Quinidine (Chinidin)
7.	dronedarone
8.	Propranolol (Inderal)
9.	Lidocaine (Xylocaine)
10.	Iodine

Related Therapies and Procedures

1.	Electric Countershock (Cardioversion)
2.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4.	Thyroidectomy
5.	Resuscitation