Transaminases

A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.

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Networked: 3323 relevant articles (102 outcomes, 179 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cunha, Burke A: 16 articles (09/2012 - 11/2003)
2.	Vajro, Pietro: 7 articles (09/2014 - 04/2004)
3.	Iorio, Raffaele: 6 articles (09/2015 - 04/2004)
4.	Pacifico, Lucia: 6 articles (12/2014 - 05/2006)
5.	Mickail, Nardeen: 6 articles (09/2012 - 01/2010)
6.	Cederbaum, Arthur I: 6 articles (11/2010 - 04/2006)
7.	Kleiner, David E: 5 articles (11/2015 - 04/2005)
8.	Chiesa, Claudio: 5 articles (12/2014 - 05/2006)
9.	Chalasani, Naga: 5 articles (08/2014 - 12/2003)
10.	Alvarez, Fernando: 5 articles (01/2014 - 09/2002)

Related Diseases

1.	Infection 03/01/1997 - "The two patients with GBV-C/HCV infection who persistently cleared hepatitis C virus but not GBV-C from serum had normal transaminases during follow-up despite persistence of GBV-C. " 12/01/1993 - "With the single dose there was improvement in the serum protein pattern towards pre-infection values & a transient rise in serum transaminases which soon declined to normal. " 05/01/2011 - "Though some studies have shown greater withdrawal rates with LEF, the incidence of infection and elevated transaminases have been comparable. " 06/01/2010 - "The objective of this study was to investigate cases of elevated aminotransferases as a manifestation of primary HIV-1 infection. " 06/01/2015 - "Thus, individuals who have been exposed to HBV are at risk of the reactivation of infection, which may result in an increase in serum aminotransferases or a flare when the immune response is suppressed. "
2.	Fibrosis (Cirrhosis) 01/01/2005 - "Aminotransferases decreased significantly between biopsies, paralleling improvement in steatosis and inflammatory features but not fibrosis stage. " 06/01/2008 - "FibroTest is effective in patients with normal transaminases, when accuracy is standardized on fibrosis stage prevalence." 08/01/2004 - "Factors independently associated with cirrhosis development were inability to have consistently normal transaminases during remission, OR 19.3 (95% CI 2.2-40), p = 0.002. " 11/01/2015 - "Our findings support the continued use of VCTE for fibrosis screening in HIV-monoinfected patients with elevated aminotransferases." 11/01/2015 - "Transient elastography for the detection of hepatic fibrosis in HIV-monoinfected adults with elevated aminotransferases on antiretroviral therapy."
3.	Liver Diseases (Liver Disease) 04/01/1986 - "Fifty-eight haemophiliacs had elevated serum aminotransferases at the time of study, but the five year review revealed only six patients who had had persistently abnormal results, although none had clinically evident liver disease. " 01/01/1960 - "[Study of blood transaminases in liver diseases]." 02/01/2015 - "FHF was defined by raised transaminases, international normalised ratio ≥ 2.0, presence of encephalopathy, and no previously recognised liver disease. " 06/01/2014 - "The presence of elevated aminotransferases on routine blood tests can reveal liver diseases of various severities. " 11/01/2012 - "Four HTR (1.5%) were chronically infected with HEV as shown by HEV-PCR and all four patients had liver transaminases of >200 IU/L and histological or clinical evidence of advanced liver disease. "
4.	Inflammation 01/01/2010 - "The aim of this study was to assess the relationships of fatness and fitness with metabolic risk factors, including liver transaminases and inflammation in obese youth, taking in account gender, age, and pubertal stage. " 09/01/2015 - "PAFR(-/-) mice fed with HC diet showed more steatosis, oxidative stress and higher transaminases levels associated with lower inflammation than WT mice. " 03/01/2014 - "Laboratory data: elevated transaminases, markers of inflammation negative, all bacterial cultures negative. " 01/01/2014 - "Although her follow-up liver biopsy indicated lymphocytic inflammation, she is now asymptomatic with normal hepatic transaminases. " 05/01/2009 - "Compared to patients with seronegative AIH patients with CLD were significantly older, had a longer duration of their disease, lower values of transaminases, more frequently a cholestatic liver enzyme pattern, a lower grade of inflammation in the liver and no response to immunosuppressive therapy. "
5.	Chronic Hepatitis C 04/01/2000 - "Re: Transient marked decrease in serum transaminases in chronic hepatitis C after surgery." 07/01/1999 - "Transient marked decrease in serum transaminases in chronic hepatitis C after surgery." 10/01/1991 - "We conclude that low-dose recombinant IFN alpha is effective in normalizing transaminases and improving the histologic appearances in at least 50% of hemophiliacs with chronic hepatitis C." 12/01/2001 - "In the present study we investigated the dynamic behavior of viral population parameters in consecutive paired liver and serum samples, obtained 3 to 6 years apart, from four chronic hepatitis C patients with persistently normal transaminases and stable liver histology. " 11/01/2013 - "Chronic hepatitis C virus (HCV) patients with persistently normal transaminases represent a subgroup of patients with mild, slowly progressive disease, natural history, and optimal management of these patients needs to be investigated in Egypt. "

Related Drugs and Biologics

1.	Bilirubin
2.	RNA (Ribonucleic Acid)
3.	Non-alcoholic Fatty Liver Disease
4.	Hepatitis B e Antigens
5.	Interferons
6.	Alkaline Phosphatase
7.	Interferon-alpha (Interferon Alfa)
8.	Triglycerides (Triacylglycerol)
9.	Antigens
10.	Metformin (Glucophage)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Nutritional Support (Artificial Feeding)
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Transplants (Transplant)
5.	Liver Transplantation