Aminopterin

01/01/1986 - "Further studies are needed to define the precise efficacy of deaza-aminopterin in patients with urothelial tract cancers."
05/01/2010 - "Renewed interest in antifols for the treatment of childhood cancers has resulted from identification of novel antifols with broad spectrums of anti-cancer activity and from re-evaluation of the original clinical antifol, aminopterin. "
07/01/2002 - "Efficacy and tolerability of an aminopterin-albumin conjugate in tumor-bearing rats."
08/01/1990 - "The value for Km derived with aminopterin was similar to that derived for either tumor cell FPGS. "
08/01/1990 - "For FPGS derived from proliferative intestinal epithelium, aminopterin was also the preferred substrate, but the value for Vmax (derived with crude cell-free extract) was 6-fold lower than for tumor cell FPGS. "

11/15/2005 - "Phase II trial of oral aminopterin for adults and children with refractory acute leukemia."
01/01/1984 - "In 1948, Farber and colleagues at the Boston Children's Hospital reported that aminopterin produced complete remissions in about one-third of children with acute leukemia. "
05/01/1963 - "Intrathecal aminopterin therapy of meningeal leukemia."
02/01/1962 - "Treatment of meningeal leukemia with intrathecal aminopterin."
01/01/1953 - "[Therapy of acute leukemia with special reference to aminopterin; case report]."

03/01/1964 - "[UNSUCCESSFUL TRIALS WITH AMINOPTERIN IN VARIOUS FORMS OF PSORIASIS]."
07/01/1972 - "[Aminopterin treatment in psoriasis]."
04/01/1965 - "CURIOSITIES IN DERMATOLOGY; A CASE OF PSORIASIS IN AN AFRICAN TREATED WITH AMINOPTERIN."
12/01/1964 - "AMINOPTERIN FOR PSORIASIS. "
12/01/1963 - "THE TREATMENT OF PSORIASIS WITH AMINOPTERIN."

05/01/2000 - "Therapeutic suppression of tissue reactivity: II. Effect of aminopterin in rheumatoid arthritis and psoriasis. "
02/01/1951 - "II. Effect of aminopterin in rheumatoid arthritis and psoriasis."
12/01/1985 - "Aminopterin, a folic acid analogue was first reported in 1948 to produce temporary remission of acute leukemia of children, was also reported in 1951 to produce an important and rapid improvement in patients with rheumatoid arthritis (RA) and psoriasis. "
03/01/1993 - "The antifolates, methotrexate, aminopterin, 10-deazaaminopterin and sulfasalazine are clinically useful in the treatment of rheumatoid arthritis. "

11/01/2007 - "A pilot open trial evaluating the efficacy of low-dose aminopterin in the canine homologue of human atopic dermatitis."
01/01/2014 - "LD-aminopterin in the canine homologue of human atopic dermatitis: a randomized, controlled trial reveals dosing factors affecting optimal therapy."