Aminooxyacetic Acid

11/01/1996 - "1. Injection of aminooxyacetic acid (AOAA) into the entorhinal cortex in vivo produces acute seizures and cell loss in medial entorhinal cortex. "
06/19/1992 - "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. "
06/19/1992 - "Age dependency of the susceptibility of rats to aminooxyacetic acid seizures."
03/01/1991 - "Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics."
01/01/1980 - "Inhibition of kindling-induced generalized seizures by aminooxyacetic acid."

01/01/2021 - "Inhibition of H2S biosynthesis in HCT116 human colon cancer cells was achieved either with aminooxyacetic acid (AOAA) or 2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one (HMPSNE). "
07/23/2013 - "Treatment of nude mice with aminooxyacetic acid attenuated the growth of patient-derived colon cancer xenografts and reduced tumor blood flow. "
01/01/2020 - "Aminooxyacetic acid (AOAA) sensitizes colon cancer cells to oxaliplatin via exaggerating apoptosis induced by ROS."
01/01/2021 - "Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept."
01/01/2016 - "Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach."

12/30/2019 - "The purpose of this study is to explore the effects of aminooxyacetic acid on hippocampus mitochondria in rats with chronic alcoholism and analyze learning and memory-related genes. "
09/01/2018 - "This study sought to observe the effect of aminooxyacetic acid on learning and memory in a chronic alcoholism rat model. "
12/30/2019 - "Effects of aminooxyacetic acid on hippocampal mitochondria in rats with chronic alcoholism: the analysis of learning and memory-related genes."
09/01/2018 - "Aminooxyacetic acid improves learning and memory in a rat model of chronic alcoholism."
06/08/2018 - "To investigate the effects of aminooxyacetic acid (AOAA) on learning and memory ability and possible mechanisms in rats with chronic alcoholism. "

08/01/1984 - "Aminooxyacetic acid (AOAA) has been shown to confer protection against noise-induced cochlear trauma [3]. "
09/01/2011 - "Aminooxyacetic acid hemihydrochloride (AOAA), an inhibitor of C-S lyase, reduced renal injuries due to cisplatin in rats, suggesting involvement of C-S lyase. "
09/01/1982 - "Aminoethoxyvinylglycine (AVG, 0.1 millimolar), CoCl(2) (1.0 millimolar), propyl gallate (PG, 1.0 millimolar) or aminooxyacetic acid (AOA, 1.0 millimolar) inhibits, whereas AgNO(3) stimulates wound ethylene formation. "
01/01/1994 - "Aminooxyacetic acid, an inhibitor of ACC-synthase activity, and 2,5-norbornadiene, an inhibitor of ethylene action, suppressed the wound-induced accumulation of ACC-oxidase mRNA, while an addition of ethylene in these tissues restored the accumulation of ACC-oxidase mRNA.(ABSTRACT TRUNCATED AT 250 WORDS)"

03/05/2023 - "The CBS/CSE inhibitor aminooxyacetic acid (AOAA) and the 3-MST inhibitor 2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one (HMPSNE) were used to assess the role of endogenous H2S in the modulation of breast cancer cell proliferation, migration, bioenergetics and viability in vitro. "
07/22/2022 - "Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer."
01/01/2018 - "Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer."
07/15/2015 - "Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate."
07/15/2015 - "Glutamine addiction in c-MYC-overexpressing breast cancer is targeted by the aminotransferase inhibitor, aminooxyacetate (AOA). "