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5-Aminolevulinate Synthetase

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Also Known As:
5-Aminolevulinate Synthase; delta-Aminolevulinic Acid Synthetase; 5 Aminolevulinate Synthase; 5 Aminolevulinate Synthetase; Acid Synthetase, Aminolevulinic; Acid Synthetase, delta-Aminolevulinic; Synthase, 5-Aminolevulinate; Synthase, delta-Aminolevulinate; Synthetase, 5-Aminolevulinate; Synthetase, Aminolevulinic Acid; Synthetase, delta-Aminolevulinic Acid; delta Aminolevulinate Synthase; delta Aminolevulinic Acid Synthetase; Aminolevulinic Acid Synthetase; delta-Aminolevulinate Synthase; Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)
Networked: 109 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Harigae, Hideo: 5 articles (01/2022 - 06/2003)
2. Furuyama, Kazumichi: 4 articles (02/2014 - 06/2003)
3. Shibahara, Shigeki: 4 articles (02/2014 - 06/2003)
4. Kaneko, Kiriko: 3 articles (02/2014 - 03/2009)
5. Balwani, Manisha: 3 articles (04/2013 - 01/2012)
6. Desnick, Robert J: 3 articles (04/2013 - 01/2012)
7. Akagi, Reiko: 3 articles (04/2005 - 01/2003)
8. Morita, Kiyoshi: 3 articles (04/2005 - 01/2003)
9. Takahashi, Toru: 3 articles (04/2005 - 01/2003)
10. Fujiwara, Tohru: 2 articles (01/2022 - 02/2014)

Related Diseases

1. Porphyrias (Porphyria)
2. X-linked sideroblastic anemia
3. Sideroblastic Anemia
4. Hepatic Porphyrias (Hepatic Porphyria)
5. Anemia

Related Drugs and Biologics

1. 5-Aminolevulinate Synthetase
2. Heme (Haem)
3. Hemin (Panhematin)
4. Enzymes
5. Pyridoxine (Pyridoxin)
6. Cytochrome P-450 Enzyme System (Cytochrome P450)
7. Hemoglobins (Hemoglobin)
8. Heme Oxygenase-1
9. Iron
10. Heme Oxygenase (Decyclizing) (Heme Oxygenase)

Related Therapies and Procedures

1. Therapeutics
2. Erythrocyte Transfusion
3. Liver Transplantation
4. Transplantation
5. Ligation