4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)

An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.

Also Known As:

4 Aminobutyrate Transaminase; GABA Aminotransferase; GABA-alpha-Ketoglutarate Aminotransferase; Aminotransferase, Aminobutyrate; Aminotransferase, GABA; Aminotransferase, GABA-alpha-Ketoglutarate; Aminotransferase, beta-Alanine Ketoglutarate; GABA alpha Ketoglutarate Aminotransferase; Ketoglutarate Aminotransferase, beta-Alanine; Transaminase, 4-Aminobutyrate; Transaminase, GABA; beta Alanine Ketoglutarate Aminotransferase; Aminobutyrate Aminotransferase; GABA Transaminase; beta-Alanine Ketoglutarate Aminotransferase; 4-Aminobutanoate:2-oxoglutarate aminotransferase

Networked: 184 relevant articles (6 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Nitrogenous Group Transferases
      - Transaminases: 11056
        4-Aminobutyrate Transaminase: 184
        Gamma aminobutyric acid transaminase deficiency: 16
        gabase
        S cerevisiae UGA1 protein

Experts

1.	Silverman, Richard B: 9 articles (10/2020 - 09/2002)
2.	Boire, Adrienne: 2 articles (07/2021 - 01/2021)
3.	Chen, Thomas: 2 articles (07/2021 - 01/2021)
4.	Danilov, Camelia: 2 articles (07/2021 - 01/2021)
5.	Das, Diganta: 2 articles (07/2021 - 01/2021)
6.	De Feyter, Henk: 2 articles (07/2021 - 01/2021)
7.	Deshpande, Krutika: 2 articles (07/2021 - 01/2021)
8.	Hurth, Kyle: 2 articles (07/2021 - 01/2021)
9.	Isakov, Danielle: 2 articles (07/2021 - 01/2021)
10.	Li, Shaobo: 2 articles (07/2021 - 01/2021)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 01/01/1999 - "Together, these data suggest that GVG may be useful for the treatment of nicotine addiction and further support the strategy of targeting the GABAergic system with a suicide inhibitor of GABA-transaminase for the treatment of drug addiction." 01/26/2012 - "Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms." 01/01/2018 - "Inhibition of GABA aminotransferase (GABA-AT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, has been established as a possible strategy for the treatment of substance abuse. " 12/01/2021 - "Many studies have focussed on modulating the activity of γ-aminobutyric acid transaminase (GABA-T), a GABA-catabolizing enzyme, for treating neurological diseases, such as epilepsy and drug addiction. " 09/26/2002 - "Four cyclohexene analogues of gamma-aminobutyric acid (GABA) and beta-alanine were designed as conformationally rigid analogues of the epilepsy and drug addiction drug vigabatrin and as potential mechanism-based inactivators of gamma-aminobutyric acid aminotransferase (GABA-AT). "
2.	Epilepsy (Aura) 01/01/2016 - "In addition, epilepsy-induced upregulation of GABA transaminase was alleviated by miR-210 inhibitor. " 09/01/2002 - "Neurotoxic effects of GABA-transaminase inhibitors in the treatment of epilepsy: ocular perfusion and visual performance." 07/21/2011 - "The inactivation mechanism of γ-aminobutyric acid aminotransferase (GABA-AT) in the presence of γ-vinyl-aminobutyric acid, an anti-epilepsy drug, has been studied by means of theoretical calculations. " 04/01/2008 - "Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina." 06/01/2000 - "Vigabatrin (Sabril), a drug that blocks GABA transaminase, has been used in the treatment of epilepsy since 1989. "
3.	Infantile Spasms (West Syndrome) 01/26/2012 - "Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms." 09/01/2012 - "Vigabatrin, an irreversible inhibitor of GABA transaminase, was approved in August 2009 for the treatment of infantile spasms in children ages 1 month to 2 years and intractable complex partial seizures in adults." 01/01/2014 - "Infantile spasms (IS) have poor outcomes and limited treatment options, including vigabatrin, a γ-aminobutyric acid (GABA) aminotransferase inactivator. " 01/12/2012 - "Vigabatrin, a GABA aminotransferase (GABA-AT) inactivator, is used to treat infantile spasms and refractory complex partial seizures and is in clinical trials to treat addiction. " 10/01/2012 - "Vigabatrin (VGB), an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase, is approved as adjunct treatment of refractory partial seizures as well as infantile spasms. "
4.	Edema (Dropsy) 12/01/2009 - "Vigabatrin, a gamma-aminobutyric acid (GABA) aminotransferase- inhibiting drug used for seizure control, has been associated with white matter vacuolation and intramyelinic edema in animal studies. " 09/01/1993 - "Vigabatrin (Sabril) is a gamma-aminobutyric acid-transaminase (GABA-T) inhibitor that is effective in the treatment of certain types of drug-resistant or uncontrolled epilepsy but is known to cause microscopic vacuolation (intramyelinic edema) in the brains of treated rats, mice, and dogs. "
5.	Drug Resistant Epilepsy 08/01/1997 - "Vigabatrin is an irreversible inhibitor of GABA-transaminase, effective in the treatment of drug-resistant epilepsy and reported to be eliminated unchanged by renal excretion. " 11/10/2021 - "Vigabatrin (VGB), a potent selective γ-aminobutyric acid transaminase (GABA-T) inhibitor, is an approved non-traditional anti-seizure drug for patients with intractable epilepsy. " 09/01/1992 - "The relationship between vigabatrin gamma-vinyl GABA (GVG, vigabatrin) daily dosage or steady-state plasma concentrations (CSS), platelet GABA-transaminase (GABA-T) inhibition, and seizure reduction were studied in 16 children with refractory epilepsy. "

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Vigabatrin
3.	Valproic Acid (Depakote)
4.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
5.	Acids
6.	Enzymes
7.	Aminobutyrates (Aminobutyric Acid)
8.	4-amino-5-hexynoic acid
9.	Glutamic Acid (Glutamate)
10.	Pentylenetetrazole (Metrazol)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Oral Administration
4.	Spinal Cord Stimulation
5.	Electroacupuncture