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4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)

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An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.

Also Known As:

4 Aminobutyrate Transaminase; GABA Aminotransferase; GABA-alpha-Ketoglutarate Aminotransferase; Aminotransferase, Aminobutyrate; Aminotransferase, GABA; Aminotransferase, GABA-alpha-Ketoglutarate; Aminotransferase, beta-Alanine Ketoglutarate; GABA alpha Ketoglutarate Aminotransferase; Ketoglutarate Aminotransferase, beta-Alanine; Transaminase, 4-Aminobutyrate; Transaminase, GABA; beta Alanine Ketoglutarate Aminotransferase; Aminobutyrate Aminotransferase; GABA Transaminase; beta-Alanine Ketoglutarate Aminotransferase; 4-Aminobutanoate:2-oxoglutarate aminotransferase

Networked: 162 relevant articles (7 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Nitrogenous Group Transferases
      - Transaminases: 3323
        4-Aminobutyrate Transaminase: 162
        Gamma aminobutyric acid transaminase deficiency: 2
        gabase

Experts

1.	Silverman, Richard B: 7 articles (01/2012 - 09/2002)
2.	Pan, Yue: 2 articles (01/2012 - 12/2003)
3.	Craft, Cheryl M: 2 articles (01/2012 - 04/2008)
4.	Trudeau, Vance L: 2 articles (09/2009 - 08/2009)
5.	Awad, Rosalie: 2 articles (09/2009 - 08/2009)
6.	Arnason, John T: 2 articles (09/2009 - 08/2009)
7.	Yuan, Hai: 2 articles (03/2007 - 12/2006)
8.	Wang, Zhiyong: 2 articles (12/2006 - 04/2006)
9.	van Rijn, Clementina M: 2 articles (04/2006 - 06/2005)
10.	McAuley, Rebecca: 2 articles (02/2005 - 09/2004)

Related Diseases

1.	Epilepsy (Aura) 09/01/2002 - "Neurotoxic effects of GABA-transaminase inhibitors in the treatment of epilepsy: ocular perfusion and visual performance." 08/01/1997 - "Vigabatrin is an irreversible inhibitor of GABA-transaminase, effective in the treatment of drug-resistant epilepsy and reported to be eliminated unchanged by renal excretion. " 09/01/1991 - "In the present study, we investigated whether the enhancement of gamma-aminobutyric acid (GABA)-mediated (GABAergic) inhibition of neurotransmission by blocking the GABA-metabolizing enzyme, GABA transaminase, could influence the histopathological and/or the behavioral outcome in this epilepsy model. " 07/21/2011 - "The inactivation mechanism of γ-aminobutyric acid aminotransferase (GABA-AT) in the presence of γ-vinyl-aminobutyric acid, an anti-epilepsy drug, has been studied by means of theoretical calculations. " 04/01/2008 - "Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina."
2.	Substance-Related Disorders (Drug Abuse) 01/26/2012 - "Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms." 01/01/1999 - "Together, these data suggest that GVG may be useful for the treatment of nicotine addiction and further support the strategy of targeting the GABAergic system with a suicide inhibitor of GABA-transaminase for the treatment of drug addiction." 09/26/2002 - "Four cyclohexene analogues of gamma-aminobutyric acid (GABA) and beta-alanine were designed as conformationally rigid analogues of the epilepsy and drug addiction drug vigabatrin and as potential mechanism-based inactivators of gamma-aminobutyric acid aminotransferase (GABA-AT). "
3.	Seizures (Seizure) 01/01/2004 - "Since previous studies indicated that a loss of GABAergic inhibition in the PC is involved in the generation of epileptic activity, we microinjected the GABA-transaminase blocker vigabatrin bilaterally in the anterior, central and posterior PC of previously amygdala-kindled rats and repeatedly tested its effect on kindled seizures. " 01/28/1984 - "Twenty-four patients with frequent drug-resistant seizures took part in a randomised double-blind placebo-controlled crossover trial of the GABA-transaminase inhibitor, gamma-vinyl GABA. " 01/01/2012 - "Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. " 01/01/2012 - "Glutamate decarboxylase and GABA aminotransferase levels in different regions of rat brain on the onset of Leptazol induced convulsions." 03/15/2007 - "Inhibition of GABA aminotransferase increases the concentration of GABA and can terminate the convulsions. "
4.	Infantile Spasms (West Syndrome) 01/26/2012 - "Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms." 01/01/2014 - "Infantile spasms (IS) have poor outcomes and limited treatment options, including vigabatrin, a γ-aminobutyric acid (GABA) aminotransferase inactivator. " 01/12/2012 - "Vigabatrin, a GABA aminotransferase (GABA-AT) inactivator, is used to treat infantile spasms and refractory complex partial seizures and is in clinical trials to treat addiction. " 10/01/2012 - "Vigabatrin (VGB), an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase, is approved as adjunct treatment of refractory partial seizures as well as infantile spasms. "
5.	Edema 09/01/1993 - "Vigabatrin (Sabril) is a gamma-aminobutyric acid-transaminase (GABA-T) inhibitor that is effective in the treatment of certain types of drug-resistant or uncontrolled epilepsy but is known to cause microscopic vacuolation (intramyelinic edema) in the brains of treated rats, mice, and dogs. " 12/01/2009 - "Vigabatrin, a gamma-aminobutyric acid (GABA) aminotransferase- inhibiting drug used for seizure control, has been associated with white matter vacuolation and intramyelinic edema in animal studies. "

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Vigabatrin
3.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
4.	Valproic Acid (Valproate, Semisodium)
5.	Picrotoxin
6.	Phenobarbital (Luminal)
7.	Anticonvulsants (Antiepileptic Drugs)
8.	Diazepam (Valium)
9.	Nicotine
10.	4-amino-5-hexynoic acid

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Self Administration (Administration, Self)
4.	Electrodes (Electrode)