Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)

A subclass of enzymes that aminoacylate AMINO ACID-SPECIFIC TRANSFER RNA with their corresponding AMINO ACIDS.

Also Known As:

Aminoacyl-tRNA Synthetase; Aminoacyl Transfer RNA Synthetase; Transfer RNA Synthetase; tRNA Synthetase; Acyl-tRNA Ligases, Amino; Acyl-tRNA Synthetases, Amino; Amino Acyl tRNA Ligases; Amino Acyl tRNA Synthetases; Aminoacyl tRNA Synthetase; Ligases, Amino Acyl-tRNA; RNA Synthetase, Transfer; Synthetase, Aminoacyl-tRNA; Synthetase, Transfer RNA; Synthetase, tRNA; Synthetases, Amino Acyl-tRNA; Amino Acyl T RNA Synthetases; Amino Acyl-tRNA Ligases

Networked: 433 relevant articles (9 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Oxygen Ligases
      - Amino Acyl-tRNA Synthetases: 433
        Histidine-tRNA Ligase: 84
        Glycine-tRNA Ligase: 66
        Methionine-tRNA Ligase: 43
        Lysine-tRNA Ligase: 39
        Tryptophan-tRNA Ligase: 39
        Alanine-tRNA Ligase: 38
        Threonine-tRNA Ligase: 30
        Aspartate-tRNA Ligase: 27
        Tyrosine-tRNA Ligase: 27
        Isoleucine-tRNA Ligase: 24
        Phenylalanine-tRNA Ligase: 21
        prolyl T RNA synthetase: 21
        Arginine-tRNA Ligase: 16
        Valine-tRNA Ligase: 16
        Serine-tRNA Ligase: 13
        glutamyl-prolyl-tRNA synthetase: 11
        Glutamate-tRNA Ligase: 8
        glutaminyl-tRNA synthetase: 8
        cysteinyl-tRNA synthetase: 7
        Leucine-tRNA Ligase: 2
        human O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase: 1
        aminoacyl tRNA synthetase p18 component
        aminoacyl-tRNA synthetase-associated protein p38
        Arabidopsis AT1G44835 protein
        Arabidopsis edd1 protein
        Arabidopsis PRORS1 protein
        Bacillus subtilis tRNA(Ile)-lysidine synthetase
        C elegans rtcb-1 protein
        E coli RtcB protein
        E coli tilS protein
        E coli YadB protein
        Euryarchaeota mj1477 protein
        human CARS2 protein
        human HARS2 protein
        human LARS2 protein
        human PARS2 protein
        Lactococcus lactis HisZ protein
        mouse FAAP protein
        S cerevisiae glutaminyl transamidase subunit F
        S cerevisiae Pus2 protein
        zebrafish Zic4 protein

Experts

1.	Kim, Sunghoon: 20 articles (11/2022 - 06/2007)
2.	Kuwana, Masataka: 19 articles (06/2022 - 05/2007)
3.	Mimori, Tsuneyo: 12 articles (01/2019 - 09/2004)
4.	Gono, Takahisa: 10 articles (01/2022 - 11/2012)
5.	Sato, Shinji: 9 articles (01/2022 - 04/2006)
6.	Kim, Dae Gyu: 8 articles (11/2022 - 10/2010)
7.	Schimmel, Paul: 8 articles (01/2021 - 01/2006)
8.	Nakashima, Ran: 7 articles (07/2021 - 01/2015)
9.	Suzuki, Shigeaki: 7 articles (03/2020 - 11/2011)
10.	Kawakami, Atsushi: 6 articles (03/2020 - 02/2015)

Related Diseases

1.	Interstitial Lung Diseases (Interstitial Lung Disease) 01/01/2022 - "Recognition of Anti-tRNA synthetase (ARS) related interstitial lung disease (ILD) is key to ensuring patients have prompt access to immunosuppressive therapies. " 01/01/2022 - "Anti-tRNA synthetase syndrome interstitial lung disease: A single center experience." 03/01/2020 - "Predictive factors for the recurrence of anti-aminoacyl-tRNA synthetase antibody-associated interstitial lung disease." 01/01/2019 - "Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia." 01/01/2019 - "The numbers of patients with classical DM, clinically amyopathic DM and interstitial lung disease were 1, 15 and 13 in the MDA5 group, 2, 3 and 11 in the aminoacyl-tRNA synthetase group, and 10, 1 and 4 in the double-negative group, respectively. "
2.	Myositis (Idiopathic Inflammatory Myopathies) 02/01/2011 - "Previous studies in humans and in animal models support a key role of histidyl-transfer RNA synthetase (HisRS; also known as Jo-1) in the pathogenesis of idiopathic inflammatory myopathy. " 01/01/2023 - "Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies." 10/01/2020 - "Serological findings showed that he had antisynthetase-associated ILD, as identified by strong positivity for anti-aminoacyl-transfer RNA synthetase (ARS) antibody, despite no evidence of myositis. " 01/01/2020 - "Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+ T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies." 04/01/2018 - "[Idiopathic Inflammatory Myopathy and Anti-aminoacyl-tRNA Synthetase Antibody]."
3.	Dermatomyositis (Dermatopolymyositis) 01/01/2022 - "To explore the clinical features and prognoses of dermatomyositis (DM) associated with a double-positive anti-MDA5 and anti-aminoacyl-tRNA synthetase (anti-ARS) antibody presentation. " 01/01/2022 - "The clinical features and prognoses of anti-MDA5 and anti-aminoacyl-tRNA synthetase antibody double-positive dermatomyositis patients." 02/01/2019 - "Dermatomyositis (40%) and anti-tRNA synthetase syndrome (45%) were the most represented IIM subtypes. " 01/01/2019 - "The optimal treatment strategy for anti-aminoacyl-tRNA synthetase antibody-positive polymyositis/dermatomyositis-associated interstitial lung disease (anti-ARS-PM/DM-ILD) is yet to be established. " 03/01/2018 - "Anti-aminoacyl-tRNA synthetase-related myositis and dermatomyositis: clues for differential diagnosis on muscle biopsy."
4.	Melanoma (Melanoma, Malignant) 03/30/2022 - "We identified 14 patients with TIF-1γ antibody-positive DM (TIF-1γ DM), 47 with anti-aminoacyl-tRNA synthetase antibody (ARS)-positive PM/DM, and 24 with anti-melanoma differentiation-associated gene 5 antibody (MDA-5)-positive PM/DM treated at the Kurume University Hospital between 2002 and 2020. " 07/06/2021 - "Anti-aminoacyl tRNA Synthetase antibody-positive cases mainly show an NSIP or FOP pattern, whereas anti-melanoma differentiation-associated gene 5 antibody-positive cases show ALI to DAD pattern. " 01/01/2020 - "We compared the NVC findings between anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive and anti-aminoacyl tRNA synthetase (anti-ARS) antibody-positive patients, the survival and ILD-related death groups, and examined the association of NVC findings with prognostic factors of DM-ILD. " 02/01/2019 - "Six patients were positive for anti-aminoacyl-tRNA synthetase antibody and two were positive for anti-melanoma differentiation-associated gene 5 antibody. " 01/01/2017 - "Two patients were anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive and 1 was anti-aminoacyl-tRNA synthetase (anti-ARS) antibody-positive. "
5.	Mitochondrial Diseases (Mitochondrial Disease) 05/01/2010 - "We demonstrated that the transfer of human mitochondrial leucyl-tRNA synthetase into the cybrid cells carrying the A3243G mutation improved the efficiency of aminoacylation and stability of mitochondrial tRNAs and then increased the rates of mitochondrial translation and respiration, consequently correcting the mitochondrial dysfunction. " 05/01/2010 - "In the present study, we have investigated the molecular mechanism of the A3243G mutation and whether the overexpression of human mitochondrial leucyl-tRNA synthetase (LARS2) in the cytoplasmic hybrid (cybrid) cells carrying the A3243G mutation corrects the mitochondrial dysfunctions. " 11/17/2023 - "When categorizing, most frequent were mitochondrial diseases (45%), disorders of vesicular trafficking (28%) and cytosolic aminoacyl-tRNA synthetase deficiencies (10%). " 01/01/2022 - "Sixteen subjects with biallelic WARS2 variants encoding the tryptophanyl mitochondrial aminoacyl-tRNA synthetase, presenting with a neonatal- or infantile-onset mitochondrial disease, have been reported to date. " 11/20/2018 - "Genetic defects in the mitochondrial aminoacyl-tRNA synthetase are important causes of mitochondrial disorders. "

Related Drugs and Biologics

1.	Antibodies
2.	Amino Acids
3.	transcriptional intermediary factor 1
4.	Leucine (L-Leucine)
5.	DNA (Deoxyribonucleic Acid)
6.	Calcineurin Inhibitors
7.	Neurotrophin 3
8.	Tacrolimus (Prograf)
9.	Tyrosine (L-Tyrosine)
10.	Thiamine (Aneurin)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)