Ameloblastoma

An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.

Also Known As:

Networked: 658 relevant articles (4 outcomes, 142 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Odontogenic Cysts (Keratocyst)
2.	Ameloblastoma
3.	Neoplasms (Cancer)
4.	Odontogenic Tumors (Dental Tissue Neoplasm)
5.	Dentigerous Cyst

Experts

1.	Kumamoto, Hiroyuki: 19 articles (09/2014 - 01/2002)
2.	Zhong, Ming: 17 articles (06/2014 - 07/2002)
3.	Wang, Jie: 15 articles (12/2007 - 07/2002)
4.	Ooya, Kiyoshi: 15 articles (09/2007 - 01/2002)
5.	Siar, Chong Huat: 13 articles (05/2015 - 09/2002)
6.	Ooya, K: 12 articles (09/2008 - 04/2001)
7.	Kumamoto, H: 12 articles (09/2008 - 04/2001)
8.	Nagatsuka, Hitoshi: 10 articles (01/2015 - 09/2002)
9.	Zhang, Bo: 9 articles (12/2007 - 04/2003)
10.	Tsujigiwa, Hidetsugu: 8 articles (01/2015 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ameloblastoma:

1.	AntibodiesIBA 04/01/1985 - "Collectively, these studies indicate that the use of specific antibodies to basement membrane components may help to differentiate ameloblastomas from malignant lesions." 09/01/2014 - "Tissue specimens of nine dental follicles and 69 ameloblastomas were immunohistochemically examined with antibodies against ATG7, LC3, and p62. " 06/01/2009 - "Fifty seven ameloblastomas were analyzed immunohistochemically with antibodies against the isoform alpha of the smooth muscle actin (alpha-SMA), a specific marker of myofibroblasts, MMP-2 and uPA. " 03/01/2006 - "Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined immunohistochemically with the use of antibodies against RB, E2F-1, and phosphorylated RB. " 02/01/2003 - "Frozen tissue sections of seven tooth germs and 22 ameloblastomas were immunohistochemically examined using anti-MMP-1, -2 and -9 and anti-TIMP-1 and -2 antibodies. "
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2006 - "In the present study, from the flow cytometry results, we found that the prolonged-treatment of TNFalpha until 24 h, resulted apoptosis in AM-1 cells (ameloblastoma cell line). " 07/01/2005 - "In the present study, we found that RANKL and TNFalpha were expressed and secreted by ameloblastoma cells, and was proven to induce osteoclastogenesis. " 04/01/2009 - "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas. " 01/01/2006 - "Inhibition of Akt and MAPK pathways elevated potential of TNFalpha in inducing apoptosis in ameloblastoma." 07/01/2005 - "These results suggested that ameloblastoma by secreting RANKL and TNFalpha could induce osteoclastogenesis."
3.	Protein Kinases (Protein Kinase)IBA 11/01/2014 - "We sought to characterize pathogenic mutations in ameloblastoma and their clinical and functional significance with an emphasis on the mitogen-activated protein kinase (MAPK) pathway. " 07/01/2004 - "K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas." 07/01/2014 - "Here we report the discovery of oncogenic mutations in the Hedgehog and mitogen-activated protein kinase (MAPK) pathways in over 80% of ameloblastomas, locally destructive odontogenic tumors of the jaw, by genomic analysis of archival material. " 01/01/2006 - "These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting TNFalpha-induced Akt and p44/42 mitogen-activated protein kinase (MAPK) cell survival pathways." 11/01/2013 - "Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway."
4.	AdenoameloblastomaIBA 03/01/2012 - "A comparative immunohistochemical study of Ki-67 and Bcl-2 expression in solid ameloblastoma and adenomatoid odontogenic tumor." 10/01/2009 - "The aim of this study was to evaluate and compare the expression of metalloproteinases-1, -2, and -9 in solid ameloblastoma and adenomatoid odontogenic tumor. " 10/01/2015 - "MMP20 expression was higher in ameloblastoma when compared to adenomatoid odontogenic tumor (AOT), DC and GOC. " 01/01/2015 - "This lesion was formerly considered to be a variant of the ameloblastoma and was designated as adenoameloblastoma. " 07/01/2014 - "Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature."
5.	Proliferating Cell Nuclear Antigen (PCNA)IBA 02/01/2003 - "This study used proliferating cell nuclear antigen (PCNA) and Ki67 to evaluate and compare the in situ proliferative activity of (1) solid and multicystic and (2) unicystic ameloblastomas in an attempt to provide a scientific basis for any differences in biologic behavior that exists between these 2 groups of lesions. " 09/01/1996 - "In the present study, we examined the immunohistochemical detection of proliferating cell nuclear antigen (PCNA) in 23 cases of ameloblastoma and evaluated the correlation between the positive index of PCNA and the clinical and histological character. " 01/01/1994 - "Immunohistochemical study on proliferating cell nuclear antigen expression in ameloblastomas." 06/01/2011 - "There was no statistical difference in PCNA intensity of staining between ameloblastomas and AOTs (P > 0.05), whereas the p53 intensity in ameloblastomas was stronger than AOTs (P < 0.05). " 06/01/2011 - "There was no significant difference in PCNA expression between ameloblastomas and AOTs (P > 0.05). "
6.	ParaffinIBA 01/01/2015 - "Sections cut from paraffin blocks, containing the representative specimens of 18 different ameloblastomas, collected in a 15-year period (1999-2014), have been observed by an environmental scanning electron microscope, in order to search micro- and nano-sized particles and to identify their composition. " 12/01/2012 - "Forty-six paraffin-embedded ameloblastoma samples and ameloblastic (AM-1) and preosteoblastic (KUSA/A1) cell lines were used. " 11/01/2007 - "Four samples of paraffin-embedded ameloblastoma with granular cells were studied. " 02/01/2013 - "The purpose of this study was to analyze SD-1 expression profile immunohistochemically in archival, paraffin-embedded tissue sections of ameloblastomas and in common odontogenic cysts arising from the same locale. " 06/01/2007 - "Paraffin-embedded specimens from 30 ameloblastomas (20 solid and 10 unicystic tumors) and 12 AOTs were submitted to immunohistochemistry using the catalyzed signal amplification system. "
7.	Messenger RNA (mRNA)IBA 01/01/2007 - "To study the expression of HOXC13 mRNA in ameloblastoma (AB), and to investigate its biological significance. " 12/01/2003 - "The purpose of this study was to characterise the mRNA expression of genes in the mouse tumours that are either expressed in human ameloblastomas or essential for normal odontogenesis and to correlate the expression to the histological phenotype. " 07/01/1992 - "In these studies, the gene expression parameters for human ameloblastomas have been characterized with the techniques of messenger RNA phenotyping in combination with Northern and in situ hybridization analysis of messenger RNA. " 01/01/2013 - "The results show that β-catenin mRNA expression was 1.24-fold higher in ameloblastomas than that in normal mucosa tissues, but AXIN2 mRNA expression was 0.47-fold lower in ameloblastomas than that in normal mucosa tissues (p < 0.05). " 12/01/2012 - "RUNX2 and C-MYC, downstream inductions of canonic WNT pathway activation, demonstrated weak mRNA expressions in ameloblastoma, suggesting WNT pathway impairment and WDR5 functional inactivity. "
8.	DNA (Deoxyribonucleic Acid)IBA 10/01/2015 - "The current study was designed to determine whether low- or high-risk HPV DNA could be detected in gnathic or peripheral ameloblastomas using in situ hybridization. " 09/01/2010 - "The purpose of this study was to detect HPV-DNA in intraosseous ameloblastomas. " 10/01/2002 - "The purpose of the study was to examine the TP53 status of ameloblastomas using newly developed yeast functional assay whose accuracy and sensitivity has been proven to be higher than those of the previous DNA structure-based methods such as single strand conformation polymorphism (SSCP) analysis. " 06/01/2002 - "The purpose of this study was to investigate the role of nuclear morphometric parameters, DNA content and Ag-NOR count in the differentiating malignant and benign ameloblastomas. " 10/01/2015 - "A small number of reports have described detection of HPV DNA within ameloblastomas. "
9.	Keratins (Keratin)IBA 04/01/1999 - "The aim of this study was to assess keratin expression in African ameloblastomas and to correlate this with their clinical and histological features. " 04/01/1999 - "An immunohistochemical study of keratin expression in ameloblastoma from a Kenyan population." 12/01/1988 - "Immunohistochemical studies of ameloblastoma with special emphasis on keratin." 04/01/2013 - "Expression of 9 major acidic epithelial keratins was immunohistochemically examined in 28 ameloblastomas. " 04/01/2013 - "The expression profiles of acidic epithelial keratins in ameloblastoma."
10.	Proteins (Proteins, Gene)IBA 09/01/1999 - "To study the possible roles of bcl-2 family proteins in oncogenesis and cytodifferentiation of odontogenic epithelium, the expression of bcl-2, bcl-x and bax proteins was examined immunohistochemically in tooth germs and various types of ameloblastoma. " 01/01/2015 - "These results suggest a synergistic role of both proteins in the process of invasion of ameloblastomas. " 06/01/2014 - "We detected a total of 782 spots in the protein profile of AC, and 19 of them, showing elevated levels compared with benign ameloblastoma, were identified using MS. These proteins have been implicated in several cellular functions, such as cell structure, metabolism, stress response, and signal transduction. " 02/01/2014 - "Results suggest that proteins studied are present and probably involved in a functional pathway in neoplastic cells and stroma and may therefore influence the local invasiveness of ameloblastoma." 02/01/2014 - "All proteins were detected in ameloblastoma. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/2012 - "Ameloblastomas have already been treated successfully with intralesional chemotherapy in dogs, why not in humans?" 12/01/1993 - "A review of the literature suggests that in the absence of effective chemotherapy or radiation, surgery should be considered the treatment of choice for metastatic ameloblastoma confined to the lung." 08/01/1989 - "Disseminated ameloblastoma does not appear to respond to chemotherapy." 01/01/1987 - "Chemotherapy of metastatic ameloblastoma. " 08/01/1991 - "Carefully applied chemotherapy combined with radiotherapy has a useful role in the management of ameloblastoma especially in an advanced maxillary tumour. "
2.	Aftercare (After-Treatment) 03/01/2009 - "Four years after treatment, the patient continued to show good results, with no recurrence of the ameloblastoma." 12/01/2011 - "Delayed soft tissue recurrence after treatment of ameloblastoma in a black African: case report and review of the literature." 06/01/2005 - "A minimum of 5 years of follow-up reviews are necessary after treatment of ameloblastoma." 07/01/2008 - "The treatment for ameloblastoma varies from curettage to en bloc resection, and the reported recurrence rates after treatment are high; the safety margin of resection is important to avoid recurrence. " 02/01/1989 - "However, as the case presented here demonstrates, even in a patient without the characteristic history of multiple recurrences and operations, ameloblastoma may appear as a metastatic lesion, usually to the lung, many years after treatment of the primary tumor. "
3.	Oral Pathology 06/01/2015 - "This study assessed the clinical, radiological, and histopathological features of 39 cases of ameloblastoma in Indian children aged less than 18 years, seen over a 41-year period (1971-2011) in the Department of Oral Pathology, Nair Hospital Dental College, India. " 11/01/2014 - "The aim of the present study was to analyze the clinicopathological features from a series of ameloblastomas diagnosed in a single Oral Pathology service in Brazil in an 8-year period. " 01/01/2015 - "Oral Pathology Quiz #86 Case Number 1.Unicystic ameloblastoma." 11/01/2014 - "Ameloblastomas: clinicopathological features from 70 cases diagnosed in a single oral pathology service in an 8-year period." 07/01/2014 - "A total of 12 cases of ameloblastoma sampled by FNAC retrieved from the archives of the Oral Pathology Department were retrospectively studied. "
4.	Oral Surgery (Maxillofacial Surgery) 06/01/2010 - "The purpose of this study is to present a series of 46 cases of ameloblastoma-38 in mandible and 8 in maxilla treated in the Oral and Maxillofacial Surgery Department of Government Dental College and Hospital, Nagpur during 1997-2006 with emphasis on various treatment modalities used in treating different types of ameloblastoma and how to define the safe margin for different clinical and histopathological types of ameloblastoma with their follow-up. " 01/01/2006 - "The aim of the study was to review all the cases of ameloblastoma seen at the Oral and Maxillofacial Surgery Clinic of the Lagos University Teaching Hospital, Nigeria, between 1980 and 2003. " 10/01/2009 - "During a 13-year period (from 1994 to 2007), in the Oral and Maxillofacial Surgery Department of the Pitié-Salpêtrière Hospital, 116 new cases of adult ameloblastomas, were analyzed for treatment composed against radiographic presentation, size, histological type. " 12/01/2006 - "The series comprised all the 18 cases of ameloblastoma of the jaw seen in patients under the age of 20 years in the two major hospitals in Jamaica with an oral and maxillofacial surgery department from 1980 to 1995. " 10/01/2004 - "10 consecutive cases of malignant ameloblastoma were treated in the Department of Oral and Maxillofacial Surgery, Ninth People's Hospital,Shanghai Second Medical University between 1991 and 2003. "
5.	Transplants (Transplant) 01/01/2013 - "we are presenting a detailed study of 50 patients in which mandible was reconstructed with non vascularised split rib graft after surgical resection of ameloblastoma. " 07/01/2015 - "We hereby present a case of unicystic ameloblastoma in a 63-year-old female and report an innovative technique of treating the case with split iliac crest graft. " 03/01/2015 - "Resection of the mandible with immediate or delayed graft reconstruction is widely used in the treatment of ameloblastoma involving a large portion of the mandible. " 01/01/2014 - "In this article, we describe a case of a multiply recurrent ameloblastoma treated by left hemimandibulectomy and immediate reconstruction with a custom-fabricated alloplastic system in combination with an anterior iliac crest bone graft. " 09/01/2013 - "A repeatedly recurrent desmoplastic ameloblastoma after removal and allobone graft: Radiographic features compared with histological changes."