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Amdinocillin Pivoxil (Pivmecillinam)

Subscribe to New Research on Amdinocillin Pivoxil

Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.

Also Known As:

Pivmecillinam; FL-1039; Leo Brand of Pivmecillinam Hydrochloride; Mecillinam Pivaloyl Ester; Pivamdinocillin; Pivmecillinam Hydrochloride; Selexid; FL 1039; FL1039; Hydrochloride, Pivmecillinam; Pivaloyl Ester, Mecillinam; Pivoxil, Amdinocillin; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((hexahydro-1H-azepin-1-yl)methylene)amino)-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (2S-(2alpha,5alpha,6beta))-

Networked: 145 relevant articles (24 outcomes, 32 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Holm, Stig E: 3 articles (04/2014 - 03/2007)
2.	Frimodt-Møller, Niels: 3 articles (03/2014 - 11/2003)
3.	Monsen, Tor J: 2 articles (04/2014 - 03/2007)
4.	Ferry, Sven A: 2 articles (04/2014 - 03/2007)
5.	Monsen, Tor: 2 articles (11/2011 - 05/2006)
6.	Lundgren, Bettina: 2 articles (11/2011 - 05/2006)
7.	Ferry, Sven: 2 articles (11/2011 - 05/2006)
8.	Wagenlehner, F M E: 2 articles (02/2011 - 01/2011)
9.	Watermann, D: 2 articles (02/2011 - 01/2011)
10.	Vahlensieck, W: 2 articles (02/2011 - 01/2011)

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 09/01/2000 - "The efficacy of pivmecillinam for empirical treatment of acute uncomplicated urinary tract infection (UTI) was initially reported in clinical trials published in the 1970s and 1980s. " 04/01/2012 - "To evaluate the clinical and bacteriological efficacy of pivmecillinam against lower urinary tract infection (UTI) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae, patients treated for lower UTI with pivmecillinam (n=8) were studied. " 04/01/2012 - "Efficacy of pivmecillinam for treatment of lower urinary tract infection caused by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae." 12/01/1987 - "[Clinical study of pivmecillinam hydrochloride in lower urinary tract infections in pregnant women. " 01/01/1984 - "In a multi-centre study in general practice, 292 female patients with acute urinary tract infection received a 5-day course of pivmecillinam at a dosage of either 200 mg or 400 mg twice-daily. "
2.	Infection 09/01/2000 - "These studies also documented that pivmecillinam was effective for treatment of Staphylococcus saprophyticus infections, was acceptable for use in pregnancy and was well tolerated. " 11/03/2003 - "[Is repeat antibiotic prescription following treatment with sulfonamide or pivmecillinam a valid method for assessment of therapeutic failure in urinary infection?]." 01/01/2002 - "Pivmecillinam is a unique beta-lactam antimicrobial that has been used for the treatment of acute uncomplicated urinary infection for > 20 y. " 12/01/1999 - "Pivmecillinam for the treatment of acute uncomplicated urinary infection." 07/01/1995 - "Pivmecillinam resistant Shigella infections in rural Bangladesh."
3.	Cystitis 10/01/2003 - "With the low resistance, its proven efficacy and favourable safety profile, pivmecillinam is a suitable first-line agent for empirical treatment of acute cystitis." 10/01/2003 - "A large number of studies from the 70s to 80s have proven the clinical efficacy and safety of pivmecillinam for empirical treatment of acute cystitis. " 09/01/2000 - "These recent studies confirm earlier reports and clinical experience that pivmecillinam is effective and well tolerated for the treatment of acute cystitis in women." 01/01/2000 - "This study has confirmed that a 3-day course of pivmecillinam is effective and well tolerated in uncomplicated cystitis." 09/01/2000 - "Subsequent widespread use of pivmecillinam in Scandinavian countries has led to a body of clinical experience which confirms the efficacy and safety of this antimicrobial agent in the treatment of acute cystitis. "
4.	Bacillary Dysentery (Shigellosis) 05/01/1984 - "The results suggest that pivmecillinam is as effective as ampicillin and can be a useful drug for the treatment of shigellosis." 04/01/1994 - "The efficacy of oral pivmecillinam was compared with nalidixic acid in the treatment of acute shigellosis in children 1-8 years of age. " 01/01/1993 - "Comparative efficacy of pivmecillinam and cotrimoxazole in acute shigellosis in children." 01/01/1993 - "In a prospective randomized double-blind trial, pivmecillinam was compared with cotrimoxazole (TMP-SMX), both given orally for a period of 5 days, for the treatment of 59 children with shigellosis. " 05/01/1984 - "The clinical efficacies of pivmecillinam and ampicillin were compared in a randomized double-blind trial in the treatment of acute shigellosis. "
5.	Bacteriuria 01/01/1983 - "In a non-randomised trial 15 women with Staphylococcus saprophyticus bacteriuria were treated with pivmecillinam 200 mg t.i.d. " 01/01/1989 - "Pivmecillinam in a single bed-time dose of 5-10 mg/kg was given as long-term prophylaxis to 20 girls with recurrent bacteriuria for a total of 228 months. " 04/01/1984 - "Pivmecillinam was given to 44 women with bacteriuria in pregnancy. " 04/01/1984 - "Pivmecillinam for bacteriuria in pregnancy." 01/01/1982 - "Long-term treatment with pivmecillinam in patients with recurrent bacteriuria."

Related Drugs and Biologics

1.	Pivampicillin
2.	Amoxicillin (Wymox)
3.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
4.	Ampicillin (Omnipen)
5.	Anti-Bacterial Agents (Antibiotics)
6.	Sulfamethizole (Thiosulfil)
7.	Cefixime (Suprax)
8.	Amdinocillin (Mecillinam)
9.	Ciprofloxacin (Cipro)
10.	Nalidixic Acid

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3.	Indwelling Catheters (Arterial Line)
4.	Aftercare (After-Treatment)
5.	Hysterectomy