HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Alfaxalone Alfadolone Mixture

Subscribe to New Research on Alfaxalone Alfadolone Mixture

A 3:1 mixture of alfaxalone with alfadolone acetate that previously had been used as a general anesthetic. It is no longer actively marketed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1445)

Also Known As:

Alfatesine; Alfathesin; Alphadione; Alphathesin; Althesin; CT-1341; Glaxovet; Saffan; Alfadolone Mixture, Alfaxalone; CT 1341; CT1341; Pregnane-11,20-dione, 21-(acetyloxy)-3-hydroxy-, (3alpha,5alpha)-, mixt. with (3alpha,5alpha)-3-hydroxypregnane-11,20-dione

Networked: 160 relevant articles (6 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Pregnanes: 3
    - Pregnanediones
      - Alfaxalone Alfadolone Mixture: 160

Experts

1.	Markos, F: 1 article (01/2009)
2.	Hall, W J: 1 article (01/2009)
3.	Ruane-O'Hora, T: 1 article (01/2009)
4.	Coney, Andrew M: 1 article (08/2007)
5.	Marshall, Janice M: 1 article (08/2007)
6.	Schwenke, Daryl O: 1 article (02/2004)
7.	Cragg, Patricia A: 1 article (02/2004)

Related Diseases

1.	Vomiting 01/01/1976 - "Frequency of nausea and vomiting after anaesthesia was considerably higher in the Althesin group than in the methohexitone group. " 04/01/1977 - "Thiopentone was associated with significantly less vomiting immediately after operation than was Althesin and ketamine. " 04/01/1977 - "Pethidine prolonged the recovery after thiopentone, decreased the incidence of vomiting immediately after operation associated with Althesin and increased that associated with ketamine." 03/01/1979 - " General anesthesia was used in 3 different ways: 1) narcoanalgesia combined with propanidid and dextromoramide, used on 103 women (21.1% of cases), resulted in a large number of cases of vomiting; 2) narcoleptoanalgesia with propanidid, dextromoramide and droperidol, used on 143 patients, (37.6%), resulted in fewer cases of vomiting; and, 3) narcoanalgesia with CT 1341 and dextromoramide, used on 79 patients, (20.7%), resulted in an even smaller number of cases of vomiting." 08/01/1984 - "There was a significantly greater frequency of vomiting after operation (P less than 0.05) with methohexitone compared with Althesin and with fentanyl compared with alfentanil, and a significantly greater frequency of pain on injection (P less than 0.001) with methohexitone compared with Althesin. "
2.	Seizures (Seizure) 08/01/1989 - "In both seizure models Saffan induced anticonvulsant activity only at doses associated with neurological deficit." 01/01/1987 - "Althesin would seem to exert a potent antiepileptic effect through a double action: i) it suppresses abnormal activity at cortical focus level ii) it depresses the multineural mechanism involved in the seizure spread at subcortical level." 06/01/1983 - "Althesin infusion in the treatment of convulsions--a case report." 03/01/1982 - "Althesin in both models always produced anticonvulsant activity which was more powerful in generalized convulsions. " 07/07/1980 - "Convulsions following althesin."
3.	Craniocerebral Trauma (Head Injury) 01/01/1988 - "Continuous EEG and ICP monitoring as a guide to the administration of althesin sedation in severe head injury." 06/01/1987 - "Althesin in the management of ICP following head injury." 03/01/1986 - "Experience with Althesin in the management of persistently raised ICP following severe head injury." 01/01/1983 - "Althesin in the management of head injuries: a preliminary report." 04/01/1985 - "The increasing use of shorter-acting hypnotic agents to control intracranial pressure (ICP) following severe head injury has prompted a prospective double-blind controlled trial comparing the efficacy of etomidate and Althesin, given by i.v. infusion. "
4.	Respiratory Insufficiency (Respiratory Failure) 10/01/1972 - "Large doses caused respiratory and circulatory depression and recovery was protracted.6. It is concluded that CT 1341 has a wider therapeutic latitude, produces less respiratory depression and has other advantages over the currently used intravenous anaesthetics." 10/01/1972 - "Aortic blood pressure and heart rates were monitored before, during and after loss of consciousness.2. CT 1341 produced rapid induction of anaesthesia followed by moderately rapid recovery, was active over a wide range of doses and caused minimal respiratory depression and few adverse effects. " 12/01/1980 - "ICI 35868 was effective in inducing anaesthesia, but produced more respiratory depression, and cardiovascular effects which were significantly different from those produced by Althesin. " 01/01/1980 - "This preliminary study will need to be completed by examination of the interference almitrine-FiO2 at different levels of anaesthesia and of respiratory depression, by study of the effects of different levels of FiO2 on the respiratory depression caused by Alfatesine and by study of the effects of the sudden administration of pure oxygen." 10/01/1972 - "It caused an initial short-lasting tachycardia and fall in aortic blood pressure succeeded by a secondary depressor response.3. The safety margin was narrower with the barbiturate drugs than with CT 1341, and large doses induced apnoea and respiratory depression. "
5.	Pain (Aches) 07/15/1982 - "This may explain the difficulties that have been encountered in obtaining adequate anaesthesia (blockade of the somatomotor response to pain) with Althesin. " 02/01/1980 - "The Authors conclude that the association of Althesin with neuroleptoanalgesia is the method of choice because it does not interfere with the fall of intraocular tension induced by the use of Althesin alone and because assure awakening without pain." 08/01/1980 - "The new drug was associated with pain and discomfort on injection in seven of 10 patients, but with less involuntary movement than occurred with Althesin." 06/01/1987 - "The sleeping time after pregnanolone was 2.5-3.5 times longer than after Althesin in dosages above 7.5 mg/kg. No signs of pain or local reaction from injection were observed for either of the drugs. " 03/01/1982 - "Disoprofol proved to be a very satisfactory agent for use by this method and apart from an appreciable incidence of pain on injection the number of complications was small and comparable to those found with Althesin, which caused more involuntary movements. "

Related Drugs and Biologics

1.	Etomidate
2.	Thiopental (Pentothal)
3.	alphaxalone (alfaxalone)
4.	Methohexital (Brevital)
5.	Ketamine
6.	Fentanyl (Sublimaze)
7.	alphadolone (alfadolone)
8.	Propofol (Diprivan)
9.	Alfentanil (Alfenta)
10.	Meperidine (Pethidine)

Related Therapies and Procedures

1.	Intermittent Positive-Pressure Ventilation
2.	Anesthesia
3.	Neuroleptanalgesia
4.	Intravenous Infusions
5.	Catheters