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alpha-Glucosidases (Acid Maltase)

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Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.

Also Known As:

Acid Maltase; Maltases; Maltase-Glucoamylase; Neutral Maltase; Neutral alpha-Glucosidase; alpha-Glucosidase; Lysosomal alpha Glucosidase; Maltase Glucoamylase; Neutral alpha Glucosidase; alpha Glucosidase; alpha Glucosidases; alpha-Glucosidase, Lysosomal; alpha-Glucosidase, Neutral; Lysosomal alpha-Glucosidase; alpha-D-Glucoside glucohydrolases

Networked: 922 relevant articles (42 outcomes, 78 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Raben, Nina: 25 articles (01/2014 - 03/2002)
2.	Kishnani, Priya S: 21 articles (01/2015 - 05/2006)
3.	Reuser, Arnold J J: 16 articles (01/2012 - 06/2002)
4.	Byrne, Barry J: 12 articles (10/2015 - 03/2002)
5.	Kroos, Marian A: 11 articles (07/2010 - 04/2002)
6.	Chen, Y T: 11 articles (11/2008 - 06/2000)
7.	Raben, N: 11 articles (08/2008 - 06/2000)
8.	Ralston, Evelyn: 10 articles (01/2014 - 04/2006)
9.	Plotz, Paul H: 10 articles (12/2010 - 11/2002)
10.	Young, Sarah P: 9 articles (01/2015 - 11/2005)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 06/01/1994 - "To compare the different therapeutic principles of alpha-glucosidase inhibitors and sulphonylureas as first-line treatment in non-insulin-dependent diabetes mellitus (NIDDM) patients with dietary failure. " 10/01/1997 - "The purpose of the study was to examine the relationship between gastric emptying and the efficacy of an alpha-glucosidase inhibitor in NIDDM patients. " 02/01/2015 - "Our study provides important molecular mechanisms to figure out alpha-glucosidase inhibition that might associate to development of type 2 diabetes mellitus drug. " 12/01/1998 - "The purpose of this study was to evaluate a long-term effect of alpha-glucosidase inhibitor treatment with ordinary meals in late dumping patients with NIDDM because administration of alpha-glucosidase inhibitor is only ethically allowed for diabetic patients in Japan. " 08/01/1994 - "Two rat models for non-insulin-dependent diabetes mellitus (NIDDM) have been used in our laboratory to study the effects of alpha-glucosidase inhibitors. "
2.	Glycogen Storage Disease Type II (Pompe's Disease) 12/01/2006 - "Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II." 09/01/2000 - "However, individuals with Pompe disease showed a marked decrease in acid alpha-glucosidase protein in both plasma and whole blood compared with unaffected controls. " 05/01/2003 - "Previously, in murine models of acid maltase deficiency (AMD), we demonstrated that intravenous administration of an improved adenovirus (Ad) vector encoding human acid alpha glucosidase (hGAA) resulted in liver transduction, followed by high-level hepatocyte-mediated secretion of hGAA into the plasma space. " 06/01/2009 - "Glycoengineered acid alpha-glucosidase with improved efficacy at correcting the metabolic aberrations and motor function deficits in a mouse model of Pompe disease." 01/01/2005 - "Impact of humoral immune response on distribution and efficacy of recombinant adeno-associated virus-derived acid alpha-glucosidase in a model of glycogen storage disease type II."
3.	Hyperglycemia 07/01/2002 - "These results suggest that the extract from ezoishige has potent alpha-glucosidase inhibitors and would be effective for suppressing postprandial hyperglycemia." 08/01/2013 - "The findings of the present study indicate that valibose may be a novel alpha-glucosidase inhibitor for the prevention from hyperglycemia in STZ-induced type 1 diabetes rats. " 09/15/2010 - "The current study shows that the extract from Nymphaea stellata flowers exhibits significant intestinal alpha-glucosidase inhibitory activity, without showing any acute toxicity or genotoxicity, which may be useful in suppressing postprandial hyperglycemia in diabetics. " 05/01/2010 - "Recent clinical studies have demonstrated that alpha-glucosidase inhibitors that improve postprandial hyperglycemia, can prevent the development of diabetes from IGT. " 05/01/2007 - "This study shows that compared to alpha-glucosidase inhibitors, DPP-IV inhibitors may have more consistent efficacy to reduce postprandial hyperglycemia, independent of the types of carbohydrate contained in a meal, and that the combination of a DPP-IV inhibitor and an alpha-glucosidase inhibitor is expected to be a promising option for lowering postprandial hyperglycemia."
4.	Diabetes Mellitus 10/01/2009 - "Finding effective mammalian alpha-glucosidase inhibitors from natural sources can be beneficial in the prevention and treatment of diabetes mellitus. " 01/01/2014 - "He suffered from diabetes mellitus and took an alpha-glucosidase inhibitor. " 01/01/2014 - "We herein report two cases of portal venous gas (PVG) following alpha-glucosidase inhibitor (α-GI) therapy for diabetes mellitus. " 08/01/2009 - "Inhibitors of alpha glucosidase have potential use in the treatment of diabetes mellitus. " 11/01/2008 - "elliptica have potential as natural nutraceuticals to prevent diabetes mellitus because of their high alpha-glucosidase inhibitory activity."
5.	Hypertension (High Blood Pressure) 07/01/2012 - "Targeting mainly postprandial hyperglycaemia, alpha-glucosidase inhibitors favourably affect several cardiovascular risk factors, such as obesity, hypertension and high glycaemic variability with little to no risk for hypoglycaemia. " 01/01/2006 - "This enhanced functionality in terms of high alpha -glucosidase and alpha -amylase inhibitory activities indicate the potential for diabetes management, and high ACE-I inhibitory activity indicates the potential for hypertension management." 01/01/2006 - "Water soluble cranberry-based phytochemical combinations with oregano, rosemary, and Rhodiola rosea were evaluated for total phenolic content, related antioxidant activity and inhibition of diabetes management-related alpha -glucosidase, pancreatic alpha-amylase inhibition, and hypertension-related ACE-I inhibitory activities. " 01/01/2010 - "Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension." 03/01/2013 - "Hypertension, chronic kidney diseases, cystic kidney diseases, kidney stones and use of alpha-glucosidase inhibitors are associated with kidney cancer."

Related Drugs and Biologics

1.	Acarbose
2.	Glucose (Dextrose)
3.	Insulin (Novolin)
4.	Metformin (Glucophage)
5.	miglitol (Glyset)
6.	voglibose
7.	Blood Glucose (Blood Sugar)
8.	human GAA protein (Myozyme)
9.	alpha-Amylases
10.	Glycogen

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Drug Therapy (Chemotherapy)
3.	Intermittent Positive-Pressure Ventilation
4.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
5.	Enzyme Therapy