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Eflornithine (Ornidyl)

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An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.

Also Known As:

Ornidyl; Vaniqa; Difluoromethylornithine; DL-alpha-Difluoromethylornithine; Eflornithine Hydrochloride; Eflornithine Monohydrochloride, Monohydrate; MDL-71,782 A; RMI 71782; Women First Brand of Eflornithine Hydrochloride; alpha-Difluoromethyl Ornithine; 71782, RMI; DL alpha Difluoromethylornithine; Hydrochloride, Eflornithine; MDL 71,782 A; MDL71,782 A; Monohydrochloride, Monohydrate Eflornithine; Ornithine, alpha-Difluoromethyl; alpha Difluoromethyl Ornithine; alpha Difluoromethylornithine; alpha-Difluoromethylornithine; Ornithine, 2-(difluoromethyl)-

Networked: 718 relevant articles (43 outcomes, 96 trials/studies)

Relationship Network

Drug Context: Research Results

Amino Acids, Peptides, and Proteins
- Amino Acids: 10808
  - Basic Amino Acids: 126
    - Ornithine: 724
      - Eflornithine: 718
        2-(fluoromethyl)dehydroornithine methyl ester: 2
        2-fluoromethylornithine: 1
        alpha-(fluoromethyl)dehydroornithine: 1
        2-(fluoromethyl)dehydroornithine ethyl ester
        DFMO-PCV protocol
  - Diamino Amino Acids: 74
    - Ornithine: 724
      - Eflornithine: 718
        2-(fluoromethyl)dehydroornithine methyl ester: 2
        2-fluoromethylornithine: 1
        alpha-(fluoromethyl)dehydroornithine: 1
        2-(fluoromethyl)dehydroornithine ethyl ester
        DFMO-PCV protocol

Experts

1.	Gerner, Eugene W: 11 articles (01/2014 - 04/2004)
2.	Manni, Andrea: 11 articles (11/2008 - 01/2003)
3.	Washington, Sharlene: 10 articles (11/2008 - 01/2003)
4.	Verderame, Michael F: 9 articles (11/2008 - 01/2003)
5.	Meyskens, Frank L: 8 articles (01/2014 - 02/2007)
6.	Steele, Vernon E: 5 articles (12/2014 - 10/2004)
7.	Pegg, Anthony E: 5 articles (04/2013 - 07/2003)
8.	McLaren, Christine E: 5 articles (10/2012 - 06/2008)
9.	Demers, Laurence M: 5 articles (01/2008 - 01/2003)
10.	Barrett, Michael P: 4 articles (01/2015 - 11/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1989 - "Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the 6L:18D photoperiod compared to 12L:12D. " 01/01/1990 - "The anticarcinogenic efficacy of the polyamine biosynthesis inhibitor, alpha-difluoromethylornithine (DFMO), was assessed in three rodent models of human epithelial cancer. " 01/01/2001 - "In this study the ability of difluoromethylornithine (DFMO) to inhibit UV-induced skin carcinogenesis when administered before or after the appearance of tumors was examined. " 02/01/1987 - "Fluorine-19 NMR studies of tumor-bearing rats treated with difluoromethylornithine." 12/01/2014 - "Interest in use of the ODC inhibitor eflornithine (DFMO) as a cancer chemopreventive agent has increased in recent years since ODC was shown to be transactivated by the c-myc oncogene and to cooperate with the ras oncogene in malignant transformation of epithelial tissues. "
2.	African Trypanosomiasis (Nagana) 01/01/2015 - "They have helped to determine the MOA of eflornithine, half of the gold standard combination therapy in use against human African trypanosomiasis (HAT), as well as the mechanism of resistance to this drug. " 03/29/2008 - "Conclusions Eflornithine shows acceptable safety and effectiveness as first line treatment for human African trypanosomiasis. " 03/29/2008 - "To assess the safety and effectiveness of eflornithine as first line treatment for human African trypanosomiasis. " 02/01/2015 - "This study may explain why oral treatment for late-stage human African trypanosomiasis (HAT) patients with racemic eflornithine has previously failed; the more potent L-enantiomer is present at much lower concentrations in both plasma and CSF than those of the D-enantiomer. " 01/01/2011 - "The aim of this study was to synthesize a series of mono-, di- and trisubstituted derivatives of the human African trypanosomiasis drug eflornithine (alpha-difluoromethylornithine, DMFO, CAS 70052-12-9) to determine their partition coefficients, and to assess whether they deliver the parent drug in the plasma. "
3.	Trypanosomiasis 01/01/2000 - "The 7-day course of eflornithine is an effective treatment of relapsing cases of Gambian trypanosomiasis. " 02/01/1988 - "Eflornithine was a safe and effective agent for treatment of trypanosomiasis with central nervous system involvement in this child." 04/01/1989 - "In a multiclinic trial in Brazzaville, Congo, 14 patients with late-stage Trypanosoma brucei gambiense trypanosomiasis were treated with eflornithine. " 04/01/1989 - "[A trial treatment with eflornithine of trypanosomiasis caused by Trypanosoma brucei gambiense in the Peoples Republic of the Congo]." 10/01/2006 - "Eflornithine seems to be a better first-line therapy for treating late-stage Gambian trypanosomiasis in the Republic of the Congo."
4.	Adenocarcinoma 11/01/2004 - "We also show that inhibition of ODC by difluoromethylornithine caused decreased cell growth and increased apoptosis in two MTAP-deleted pancreatic adenocarcinoma-derived cell lines. " 11/01/2004 - "In addition, we examined the effect of the ODC inhibitor difluoromethylornithine on two pancreatic adenocarcinoma-derived cell lines. " 01/01/2000 - "Isolation and characterization of human breast adenocarcinoma cells made resistant to alpha-difluoromethylornithine." 06/01/1988 - "We studied the effect of inhibition of polyamine biosynthesis by alpha-difluoromethylornithine on the growth of a human gastric adenocarcinoma (CLEES) xenotransplanted in nude mice. " 06/01/1988 - "The effect of the polyamine biosynthesis inhibitor alpha-difluoromethylornithine (DFMO) on the in vitro radiation response of Clone A human colon adenocarcinoma cells was investigated. "
5.	Infection 03/01/2012 - "However, out of five patients who died from encephalopathy syndrome during treatment with eflornithine, three harbored multiple infections." 04/01/2011 - "Furthermore, supplying α-difluoromethylornithine, an ODC inhibitor, at 2% in the drinking water reduced but did not eliminate infection with wild type L. " 11/01/2008 - "Concentrations of brain parasites increased during the infection and this resulted in detectable blood-brain barrier, but not choroid plexus, dysfunction at day 28 post-infection with resultant increases in eflornithine brain delivery. " 12/01/1993 - "Effect of a bis(benzyl)polyamine analogue, and DL-alpha-difluoromethylornithine on parasite suppression and cellular polyamine levels in golden hamster during Leishmania donovani infection." 04/01/1991 - "These changes occurred regardless of whether the stumpy trypanosomes were generated naturally during the course of the infection or induced by difluoromethylornithine treatment. "

Related Drugs and Biologics

1.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
2.	Eflornithine (Ornidyl)
3.	Nifurtimox
4.	Mitoguazone (MGBG)
5.	Piroxicam (Feldene)
6.	Aspirin (Acetylsalicylic Acid)
7.	Bleomycin (Blenoxane)
8.	Suramin (Suramin Sodium)
9.	melarsen oxide
10.	Putrescine

Related Therapies and Procedures

1.	Oral Administration
2.	Heterologous Transplantation (Xenotransplantation)
3.	Chemoprevention
4.	Drug Therapy (Chemotherapy)
5.	Lasers (Laser)