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alpha-Amylases

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Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.

Also Known As:

Alpha-Amylase Bayer; Bayer Brand of alpha-Amylase; Leurquin Brand of alpha-Amylase; Maxilase; Mégamylase; Sanofi Synthelabo Brand of alpha-Amylase; alpha-1,4-D-Glucanglucanohydrolase; Alpha Amylase Bayer; AlphaAmylase Bayer; Taka Amylase A; TakaAmylase A; alpha 1,4 D Glucanglucanohydrolase; alpha Amylase; alpha Amylases; Taka-Amylase A; alpha-Amylase; 1,4-alpha-D-Glucan glucanohydrolase

Networked: 429 relevant articles (8 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Glycoside Hydrolases: 275
      - Amylases: 4410
        alpha-Amylases: 429
        Arabidopsis BE1 protein
        Bacillus licheniformis alpha-amylase
        glycosylated alpha-amylase
        Hordeum vulgare AMY1.2 protein
        Pancreatic alpha-Amylases
        Pseudoalteromonas haloplanktis alpha-amylase carboxy terminal propeptide
        S pombe AAH3 protein
        Salivary alpha-Amylases
        Sulfolobus solfataricus trehalosyl dextrin-forming enzyme

Experts

1.	Shetty, Kalidas: 8 articles (06/2010 - 01/2005)
2.	Kwon, Young-In: 6 articles (06/2010 - 01/2005)
3.	Nater, Urs M: 5 articles (01/2016 - 04/2006)
4.	Apostolidis, Emmanouil: 5 articles (06/2010 - 06/2008)
5.	Ishitobi, Yoshinobu: 4 articles (07/2015 - 03/2012)
6.	Kawano, Aimi: 4 articles (07/2015 - 03/2012)
7.	Ninomiya, Taiga: 4 articles (07/2015 - 03/2012)
8.	Tanaka, Yoshihiro: 4 articles (07/2015 - 03/2012)
9.	Kanehisa, Masayuki: 4 articles (07/2015 - 03/2012)
10.	Akiyoshi, Jotaro: 4 articles (07/2015 - 03/2012)

Related Diseases

1.	Hyperglycemia 01/01/2010 - "Flavonoids have been reported as mammalian alpha-amylase inhibitors, a property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. " 07/01/2015 - "The present study seeks an alternative drug that can regulate the hyperglycemia by down-regulating alpha-glucosidase and alpha-amylase activity by molecular docking approach to screen the hyperglycemia antagonist against alpha-glucosidase and alpha-amylase activities from the 47 natural compounds. " 06/01/2010 - "High phenolic and antioxidant activity-containing medicinal plants and spices such as Chancapiedra (Phyllantus niruri L.), Zarzaparrilla (Smilax officinalis), Yerba Mate (Ilex paraguayensis St-Hil), and Huacatay (Tagetes minuta) had the highest anti-hyperglycemia relevant in vitro alpha-glucosidase inhibitory activities with no effect on alpha-amylase. " 01/01/2010 - "Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension." 11/01/2013 - "The aim of this study was to evaluate the in vitro inhibitory effect of Azadirachita indica leaf extract on the activity of alpha-amylase and alpha-glucosidase as a means of alleviating hyperglycemia and managing diabetes mellitus. "
2.	Neoplasms (Cancer) 07/01/2012 - "To assess the validity of filter paper (FP) against the gold standard of passive drool (PD) for collecting salivary alpha amylase as a surrogate biomarker of psychological stress in adolescents with cancer. " 11/01/1981 - "Structural study of the sugar chains of alpha-amylases produced ectopically in tumors." 07/01/2012 - "Eluted FP may not be a valid method for collecting salivary alpha amylase in adolescents with cancer. " 07/01/2012 - "Assessing agreement between salivary alpha amylase levels collected by passive drool and eluted filter paper in adolescents with cancer." 01/01/2009 - "The statistically significant stronger expression of CK7 in ONC and stronger expression of PAS and alpha-amylase in ACC in routine practice each is hampered by a pronounced overlap between both tumor groups. "
3.	Pancreatitis 01/01/2014 - "The average values of the alpha amylase, LDH and ALT were significantly higher in the group of severe form of the acute pancreatitis compared to the group of moderate form. " 11/30/2007 - "In transgenic rats with activated polyamine catabolism, all the isomers similarly restored liver regeneration and reduced plasma alpha-amylase activity associated with induced pancreatitis. " 11/01/2006 - "To verify that our model was inducing pancreatitis, alpha-amylase activity was measured in the cell culture supernatant by fluorescence spectroscopy. " 01/19/2004 - "In addition peritoneal lavage prevented the increase in alpha-amylase and XDH+XOD in plasma after induction of pancreatitis. " 01/19/2004 - "Similar increase in XDH+XOD activity in plasma was observed after induction of acute pancreatitis and after i.v. administration of alpha-amylase. "
4.	Hypersensitivity (Allergy) 01/01/2005 - "The aim of the study was to evaluate the prevalence, incidence and risk factors of hypersensitivity to alpha-amylase as well as to identify allergy-related clinical symptoms in apprentice bakers. " 01/01/2015 - "Sensitization to flour or fungal alpha-amylase is a prerequisite for the development of respiratory allergy in bakers. " 01/01/2005 - "The incidence of allergy to alpha-amylase increases with increasing duration of exposure. " 01/01/2005 - "Generally, 28 (9.8%) apprentices showed hypersensitivity to alpha-amylase after two years of occupational exposure. " 01/01/2005 - "After the first year of occupational exposure, one subject developed hypersensitivity to alpha-amylase, and other 27 subjects after the second year. "
5.	Inflammation 01/01/2003 - "Pancreatic inflammation was evaluated by serum alpha-amylase activity, pancreatic weight and histological changes in the pancreatic tissue. " 02/01/1994 - "The high practicability and interlaboratory transferability documented in the results of the collaborative study show that the pancreatic alpha-amylase assay is very useful for recognizing pancreatic inflammations, especially in combination with lipase." 09/01/2008 - "To explore this fluid shift and its possible mechanisms in more detail, prospectively collected data from one such trial, including measures of inflammation (C-reactive protein, tumour necrosis factor-alpha, albumin and low and high molecular weight hyaluronan) ANP (atrial naturetic peptide), an indirect marker of intra-vascular volume, plasma concentrations of icodextrin metabolites and alpha-amylase activity were analysed. "

Related Drugs and Biologics

1.	alpha-Glucosidases (Acid Maltase)
2.	Lipase (Acid Lipase)
3.	Isoenzymes
4.	Allergens
5.	Isoamylase
6.	Flavonoids
7.	Hydrocortisone (Cortisol)
8.	Enzymes
9.	Proteins (Proteins, Gene)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Massage (Reflexology)
2.	Fluid Therapy (Oral Rehydration Therapy)
3.	Transplants (Transplant)
4.	Radiotherapy
5.	Phytotherapy (Herbal Therapy)