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alpha 1-Antitrypsin (alpha 1 Antitrypsin)

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Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.

Also Known As:

alpha 1 Antitrypsin; Zemaira; alpha 1 Proteinase Inhibitor; A1PI; Prolastin; Serpin A1; alpha 1 Antiprotease; alpha 1-Antiproteinase; 1-Antiproteinase, alpha; Antiprotease, alpha 1; Inhibitor, alpha 1-Protease; Inhibitor, alpha 1-Proteinase; Trypsin Inhibitor, alpha 1 Antitrypsin; alpha 1 Antiproteinase; alpha 1 Protease Inhibitor; Trypsin Inhibitor, alpha 1-Antitrypsin; alpha 1-Protease Inhibitor; alpha 1-Proteinase Inhibitor

Networked: 1483 relevant articles (40 outcomes, 124 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
- Peptides: 22950
  - Serpins: 202
    - alpha 1-Antitrypsin: 1483
  - Secretory Proteinase Inhibitory Proteins: 23
    - Serpins: 202
      - alpha 1-Antitrypsin: 1483
        alpha 1-antitrypsin Pittsburgh: 3
        trypsin-2-alpha1-antitrypsin: 3
        alpha 1-antitrypsin-leukocyte elastase complex: 2
        alpha 1-antitrypsin Christchurch
        alpha 1-antitrypsin Portland
        alpha 1-antitrypsin QOtrastevere
        alpha 1-antitrypsin Siiyama
        alpha 1-antitrypsin W(Bethesda)
        C105Y peptide
        human serpin A1 (A1-C26)
        human SERPINA1 protein
        human SERPINA2 protein
        human VIRIP peptide
        S cerevisiae A1PiZ protein
        S variant alpha 1-antitrypsin

Experts

1.	Janciauskiene, Sabina: 4 articles (06/2014 - 05/2003)
2.	Barr, Philip J: 4 articles (07/2006 - 08/2003)
3.	Pemberton, Philip A: 4 articles (07/2006 - 08/2003)
4.	Stockley, Robert A: 3 articles (01/2015 - 06/2002)
5.	Antonelli, Patrick J: 3 articles (07/2006 - 08/2003)
6.	Schultz, Gregory S: 3 articles (07/2006 - 08/2003)
7.	Sundin, David J: 3 articles (07/2006 - 08/2003)
8.	Perlmutter, D H: 3 articles (11/2001 - 02/2000)
9.	Piitulainen, Eeva: 2 articles (07/2015 - 01/2009)
10.	Joly, Philippe: 2 articles (01/2015 - 11/2014)

Related Diseases

1.	Crohn Disease (Crohn's Disease) 01/01/1983 - "We conclude that: (a) fecal alpha 1-antitrypsin excretion may be helpful in assessing the presence or absence of Crohn's disease activity by providing an objective and specific indicator of intestinal damage; and (b) it appears that a simple subjective rating score is as clinically useful as other previously devised activity indices." 03/01/1985 - "The measurement of alpha 1-antitrypsin clearance provides a useful adjunctive technique in evaluating intestinal inflammatory activity, and it seems to be of use in following the efficacy of treatment in the course of illness in Crohn's disease." 04/01/1993 - "[Fecal excretion and the clearance of alpha 1-antitrypsin in patients with Crohn's disease]." 03/01/1991 - "The aim of this study was to evaluate in Crohn's disease the possible usefulness of alpha 1-antitrypsin clearance and fecal concentration in the early detection of postoperative asymptomatic recurrence. " 11/01/1988 - "Qualitative study of fecal alpha 1-proteinase inhibitor in normal subjects and patients with Crohn's disease."
2.	Protein-Losing Enteropathies (Protein-Losing Enteropathy) 01/01/1990 - "[Protein-losing enteropathy of cardiac origin: value of intestinal clearance of alpha-1-antitrypsin]." 03/11/1982 - "[Evaluation of protein-losing enteropathy in the cirrhotic patient by assessing the intestinal clearance of alpha 1 antitrypsin (author's transl)]." 10/01/1981 - "In conclusion, the fecal clearance of alpha 1-antitrypsin seems to be an inexpensive and quite reliable test of protein-losing enteropathy." 02/01/1981 - "[Intestinal clearance of alpha 1-antitrypsin and exudative enteropathy]." 09/01/1990 - "Diagnosis of protein-losing enteropathy can be successfully made by radioisotopic studies or 24-hour stool alpha 1-antitrypsin clearance. "
3.	Emphysema 04/01/2015 - "The SPARTA trial is designed to evaluate the long-term (3-year) efficacy of 2 separate doses of Prolastin-C for the treatment of emphysema in patients with AATD. " 09/01/1997 - "In a randomized placebo-controlled study of alpha 1-antitrypsin augmentation therapy, 22 patients with moderate emphysema were followed for 2-4 years with an annual lung CT. " 06/01/1993 - "The aim of this study was to evaluate the ability of alveolar inflammatory cells recovered by bronchoalveolar lavage from the lower respiratory tract of 17 smoking patients with or without emphysema to inactivate alpha 1-proteinase inhibitor (alpha 1-Pl). " 02/01/1993 - "This hypothesis derives largely from studies in emphysema patients with genetic deficiency in serum alpha 1-antitrypsin. " 07/25/2015 - "Measurement of lung density with CT at TLC alone provides evidence that purified A1PI augmentation slows progression of emphysema, a finding that could not be substantiated by lung density measurement at FRC alone or by the two measurements combined. "
4.	alpha 1-Antitrypsin Deficiency (alpha 1 Antitrypsin Deficiency) 04/23/1987 - "We evaluated the feasibility, safety, and biochemical efficacy of intermittent infusions of alpha 1-antitrypsin in the treatment of patients with alpha 1-antitrypsin deficiency. " 01/01/1983 - "Increased intestinal clearance of alpha 1-antitrypsin in patients with alpha 1-antitrypsin deficiency." 03/14/1983 - "The study group included 59 PI type Z patients with alpha 1-antitrypsin deficiency, five with the rare alpha 1-antitrypsin null genotype (PI Q0 or --), and seven with alpha 1-antitrypsin deficiency of the rare PI types MmaltonZ or MduarteZ. " 01/01/2012 - "Serum from 15 patients with documented alpha 1-antitrypsin deficiency, some of whom were receiving alpha 1-antitrypsin augmentation therapy, and four normal volunteers was analyzed. " 12/01/1996 - "This report describes the clinical characteristics of a group of 59 individuals with the PI*SZ phenotype and alpha 1-antitrypsin (alpha 1-AT) deficiency, identified during recruitment of a registry for subjects with severe alpha 1-antitrypsin deficiency. "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/01/1992 - "The intestinal clearance of alpha 1-antiproteinase was significantly increased in all patients with inflammatory bowel diseases (p less than 0.01), irrespective of the grade of the disease. " 01/01/1984 - "We evaluated fecal clearance of alpha 1-antitrypsin (alpha 1-AT) as a method of detecting and quantitating intestinal protein loss in patients with inflammatory bowel disease. " 07/01/1999 - "The natural course of fecal alpha 1-antitrypsin (AAT) excretion was assessed in patients with inflammatory bowel disease (IBD) to evaluate its role in monitoring their clinical disease activity. " 07/01/1999 - "Quantification of fecal alpha 1-antitrypsin (AAT) excretion is established for estimation of enteric protein loss and assessment of disease activity in inflammatory bowel disease (IBD). " 02/21/1998 - "Quantification of fecal alpha 1-antitrypsin excretion for assessment of inflammatory bowel diseases."

Related Drugs and Biologics

1.	alpha-Macroglobulins (alpha 2 Macroglobulin)
2.	alpha 1-Antitrypsin (alpha 1 Antitrypsin)
3.	Proteins (Proteins, Gene)
4.	Immunoglobulin G (IgG)
5.	Leukocyte Elastase (Neutrophil Elastase)
6.	Transferrin (beta 2 Transferrin)
7.	Trypsin
8.	Protease Inhibitors (Protease Inhibitor)
9.	Immunoglobulin A (IgA)
10.	Pancreatic Elastase (Elastase)

Related Therapies and Procedures

1.	Remission Induction
2.	Ileostomy
3.	Hypophysectomy
4.	Total Parenteral Nutrition
5.	Transplants (Transplant)