alpha 1-Antichymotrypsin (alpha 1 Antichymotrypsin)

Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.

Also Known As:

Networked: 353 relevant articles (3 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Friis, Henrik: 5 articles (01/2009 - 12/2002)
2.	Lomas, D A: 5 articles (10/2007 - 01/2000)
3.	Krarup, Henrik: 4 articles (01/2009 - 12/2002)
4.	Kaestel, Pernille: 3 articles (01/2009 - 12/2002)
5.	Lomas, David A: 3 articles (01/2009 - 03/2003)
6.	Nilsson, L N: 3 articles (11/2001 - 03/2001)
7.	Potter, H: 3 articles (11/2001 - 03/2001)
8.	Brux, B: 3 articles (09/2001 - 11/2000)
9.	Loening, S A: 3 articles (09/2001 - 11/2000)
10.	Lein, M: 3 articles (09/2001 - 11/2000)

Related Diseases

1.	Dementia (Dementias) 10/01/1989 - "DAT group showed statistically significant increase of serum alpha 1-antichymotrypsin content, as compared with normal control group (p less than 0.001), mixed type dementia group (p less than 0.05) and other 6 groups (p less than 0.001). " 02/01/1997 - "Absence of the A1252G mutation in alpha 1-antichymotrypsin in a North American population suffering from dementia." 10/01/1990 - "CSF levels of alpha 1-antichymotrypsin tended to parallel the severity of dementia. " 10/01/1989 - "We have evaluated serum alpha 1-antichymotrypsin content in dementia of the Alzheimer type (DAT). " 07/15/2005 - "Post-stroke dementia is associated with alpha(1)-antichymotrypsin polymorphism."
2.	Polymyalgia Rheumatica (Rhizomelic Pseudopolyarthritis) 06/01/1990 - "Microheterogeneity of alpha 1-antichymotrypsin in the management of giant-cell arteritis and polymyalgia rheumatica." 06/01/1994 - "Alpha 1-antichymotrypsin, C-reactive protein and erythrocyte sedimentation rate in polymyalgia rheumatica and giant cell arteritis." 01/01/1991 - "We also studied the variations of alpha 1-antichymotrypsin microheterogeneity in sera from patients with giant-cell arteritis and/or polymyalgia rheumatica before and during treatment with glucocorticoids.(ABSTRACT TRUNCATED AT 250 WORDS)" 06/01/1990 - "1. Using crossed immunoaffinity electrophoresis with free concanavalin A in the first dimension, we studied the glycan microheterogeneity of alpha 1-antichymotrypsin in sera from patients with giant-cell arteritis and/or polymyalgia rheumatica, and its variation in the serum of several of these patients during induction of disease remission by prednisone therapy and possible further recurrence of giant-cell arteritis and/or polymyalgia rheumatica. " 08/01/1990 - "The genes coding for the protease inhibitors alpha 1-antitrypsin (A1AT) and alpha 1-antichymotrypsin (A1ACT) were analysed by Southern blot in patients with rheumatoid arthritis, psoriatic arthritis, psoriasis without arthritis, polymyalgia rheumatica and generalized osteoarthritis. "
3.	Lung Diseases (Lung Disease) 01/01/2001 - "These data indicate that deficiency of alpha(1)-antichymotrypsin is associated with less severe pulmonary disease in patients with CF, and support our previous observations that mild genetic deficiency of a proteinase inhibitor is associated with an improved outcome." 01/01/2001 - "In a multivariate analysis these individuals had significantly less severe lung disease than those who had normal or raised levels of alpha(1)-antichymotrypsin: forced expiratory volume in one second (FEV(1)) 69.9% predicted versus 53. " 09/04/1993 - "Mis-sense mutation of alpha 1-antichymotrypsin gene and chronic lung disease." 07/01/1993 - "The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease." 06/20/1992 - "Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease."
4.	Giant Cell Arteritis (Horton Disease) 06/01/1990 - "Microheterogeneity of alpha 1-antichymotrypsin in the management of giant-cell arteritis and polymyalgia rheumatica." 06/01/1994 - "Alpha 1-antichymotrypsin, C-reactive protein and erythrocyte sedimentation rate in polymyalgia rheumatica and giant cell arteritis." 01/01/1991 - "We also studied the variations of alpha 1-antichymotrypsin microheterogeneity in sera from patients with giant-cell arteritis and/or polymyalgia rheumatica before and during treatment with glucocorticoids.(ABSTRACT TRUNCATED AT 250 WORDS)" 06/01/1990 - "1. Using crossed immunoaffinity electrophoresis with free concanavalin A in the first dimension, we studied the glycan microheterogeneity of alpha 1-antichymotrypsin in sera from patients with giant-cell arteritis and/or polymyalgia rheumatica, and its variation in the serum of several of these patients during induction of disease remission by prednisone therapy and possible further recurrence of giant-cell arteritis and/or polymyalgia rheumatica. "
5.	Alzheimer Disease (Alzheimer's Disease) 04/03/2000 - "Genetic association study between alpha 1-antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population." 05/28/1993 - "This suggests that alpha 1-antichymotrypsin staining might identify a different facet of the pathology of Alzheimer's disease than does neurofibrillary tangle staining and may provide new information in the study of this condition." 05/01/2002 - "Distribution of plasma alpha 1-antichymotrypsin levels in Alzheimer disease patients and controls and their genetic controls." 04/01/2002 - "Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease." 11/01/2001 - "We discuss our findings in terms of a model in which cytokine-induced alpha(1)-antichymotrypsin synthesis in astrocytes constitutes a specific inflammatory pathway that accelerates the development of Alzheimer's disease and could at least partly underlie the regional specificity and species restriction of the neuropathology."

Related Drugs and Biologics

1.	Concanavalin A
2.	Prednisone (Sone)
3.	alpha 1-Antitrypsin (alpha 1 Antitrypsin)
4.	Muramidase (Lysozyme)
5.	Amyloid (Amyloid Fibrils)
6.	Proteins (Proteins, Gene)
7.	Apolipoproteins
8.	Serine Proteases (Serine Protease)
9.	Vimentin
10.	Orosomucoid (Seromucoid)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Immunotherapy
3.	Transplants (Transplant)
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Intraperitoneal Injections