Follicular Mucinosis

A disease of the pilosebaceous unit, presenting clinically as grouped follicular papules or plaques with associated hair loss. It is caused by mucinous infiltration of tissues, and usually involving the scalp, face, and neck. It may be primary (idiopathic) or secondary to mycosis fungoides or reticulosis.

Also Known As:

Networked: 72 relevant articles (5 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Mycosis Fungoides
2.	Follicular Mucinosis
3.	Skin Diseases
4.	Alopecia (Baldness)
5.	Mucinoses

Experts

1.	Lee, J Yu-Yun: 2 articles (01/2004 - 05/2003)
2.	Tsai, Ya-Ming: 2 articles (01/2004 - 05/2003)
3.	Moser, J: 1 article (08/2015)
4.	Sedivy, R: 1 article (08/2015)
5.	Trautinger, F: 1 article (08/2015)
6.	Kitzwögerer, M: 1 article (08/2015)
7.	Eder, J: 1 article (08/2015)
8.	Kern, A: 1 article (08/2015)
9.	Maquiné, Gustavo Ávila: 1 article (05/2015)
10.	Pennini, Silmara Navarro: 1 article (05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Follicular Mucinosis:

1.	Minocycline (Cyclops)FDA LinkGeneric 01/01/2010 - "In this report, we describe a patient with clonal idiopathic primary follicular mucinosis who had complete clinical, histologic, and molecular remission with minocycline therapy." 03/01/2003 - "We report a case of idiopathic alopecia mucinosa that responded to minocycline with a complete remission and we review the literature on alopecia mucinosa." 04/01/2000 - "A case of follicular mucinosis treated successfully with minocycline." 01/01/2010 - "Follicular mucinosis: clinical, histologic, and molecular remission with minocycline."
2.	pimecrolimus (Elidel)FDA Link 01/01/2009 - "A case of follicular mucinosis treated successfully with pimecrolimus."
3.	imiquimod (Aldara)FDA LinkGeneric 05/01/2014 - "Treatment of primary follicular mucinosis with imiquimod 5% cream." 05/01/2014 - "We present a case of primary follicular mucinosis in which complete clinical remission was achieved after treatment with topical imiquimod 5%. "
4.	MucinsIBA 11/01/2013 - "Follicular mucinosis (FM) is an uncommon reaction pattern in which the accumulation of mucin in the follicular epithelium is the main pathologic finding. " 03/01/2013 - "Features of follicular mucinosis were observed in the same section with 3 hyperplastic follicular infundibula containing pools of mucin in the infundibular epithelium. " 01/01/2013 - "Follicular mucinosis is recognized as one of the histopathological reaction patterns characterized by the accumulation of mucin within follicular epithelium. " 01/01/2013 - "Follicular mucinosis is a disease characterized by follicular degeneration and mucin accumulation. " 08/01/2011 - "Follicular mucinosis is a rare inflammatory disorder of unknown aetiology, characterized by mucin deposition in hair follicles and sebaceous glands. "
5.	Isotretinoin (Accutane)FDA LinkGeneric 12/01/2004 - "He was diagnosed as primary benign generalized follicular mucinosis, and treated with isotretinoin. " 12/01/2004 - "Follicular mucinosis responding to isotretinoin treatment." 01/01/1999 - "To the best of our knowledge, the benefits of isotretinoin in the treatment of follicular mucinosis have never been reported previously. " 01/01/1999 - "We describe the case of a 33-year-old Caucasian male with follicular mucinosis successfully treated with isotretinoin. " 01/01/1999 - "Follicular mucinosis successfully treated with isotretinoin."
6.	T-Cell Antigen Receptors (T-Cell Receptor)IBA 11/01/1997 - "Follicular mucinosis, Staphylococcus aureus, and oligoclonal expansion of the T-cell receptor V beta chain genes 6 and 7 were present in the skin. " 05/01/1988 - "Clonal rearrangement of the T cell receptor beta gene in the circulating lymphocytes of erythrodermic follicular mucinosis." 11/01/1997 - "Follicular mucinosis associated with scarring alopecia, oligoclonal T-cell receptor V beta expansion, and Staphylococcus aureus: when does follicular mucinosis become mycosis fungoides?" 01/01/2004 - "To investigate T-cell clonality in a series of eosinophilic pustular folliculitis with follicular mucinosis, we performed heteroduplex analysis of re-arranged T-cell receptor gamma gene in seven cases of eosinophilic pustular folliculitis with follicular mucinosis. " 11/01/1993 - "Southern blot analysis of immunoglobulin and T-cell antigen receptor gene rearrangements may fail to aid the clinician in establishing a diagnosis of a cutaneous malignancy due to the limits of detection sensitivity in minimally infiltrated lesions (eg, parapsoriasis and patch-stage mycosis fungoides) or the still uncertain prognostic significance of clonality in benign cutaneous diseases (eg, follicular mucinosis, pityriasis lichenoides et varioliformis acuta, lymphomatoid papulosis, and cutaneous lymphoid hyperplasia). "
7.	InterferonsIBA 05/01/1991 - "Successful treatment of primary progressive follicular mucinosis with interferons." 06/01/2001 - "Follicular mucinosis associated with early stage cutaneous T-cell lymphoma: successful treatment with interferon alpha-2b and acitretin." 01/01/2003 - "We present a case of mycosis fungoides with follicular mucinosis that was treated with incomplete courses of interferon, isotretinoin, and polychemotherapy with subsequent rapid progression to tumor-stage mycosis fungoides with large cell transformation and nodal and bone marrow involvement. "
8.	DapsoneFDA Link 08/01/1974 - "Follicular mucinosis responding to dapsone." 01/01/2003 - "Urticaria-like follicular mucinosis responding to dapsone." 09/01/1989 - "Follicular mucinosis presenting as acute dermatitis and response to dapsone."
9.	Eosinophilic pustular folliculitisIBA 12/01/2006 - "Diagnosis: Eosinophilic pustular folliculitis (Ofuji's disease) with follicular mucinosis." 01/01/2004 - "The failure to demonstrate clonality may be consistent with a reactive nature of eosinophilic pustular folliculitis with follicular mucinosis." 01/01/2004 - "Follicular mucinosis has been observed in lesions of eosinophilic pustular folliculitis. " 01/01/2004 - "Failure to detect clonality in eosinophilic pustular folliculitis with follicular mucinosis." 01/01/2004 - "Clinical and histological features of eosinophilic pustular folliculitis with follicular mucinosis and alopecia mucinosa are very similar. "
10.	Indomethacin (Indometacin)FDA LinkGeneric 02/01/1988 - "Follicular mucinosis: response to indomethacin." 08/01/2009 - "Successful Treatment of Recalcitrant Primary Follicular Mucinosis with Indomethacin and Low-dose Intralesional Interferon Alpha."

Therapies and Procedures

1.	Aftercare (After-Treatment) 05/01/2014 - "We present a case of primary follicular mucinosis in which complete clinical remission was achieved after treatment with topical imiquimod 5%. "
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 06/01/2012 - "Mycosis fungoides-associated follicular mucinosis after bone-marrow transplantation." 01/01/2004 - "Follicular mucinosis occurring after bone marrow transplantation in a patient with acute lymphoblastic leukemia."
3.	Laser Therapy (Surgery, Laser) 07/01/1988 - "Our own results in dermatology are highlighted, such as the oral "hairy" leukoplakia associated with AIDS, treatment with Acyclovir for herpetic infections, laser therapy for angiomas, Lyme disease, x-ray therapy in Kaposi's sarcomas, photosensitivity reactions by treatment with thiazid diuretics and follicular mucinosis associated with T-cell lymphomas (mycosis fungoides)."
4.	Stem Cell Transplantation 08/01/2011 - "A novel case of follicular mucinosis after autologous stem-cell transplantation for multiple myeloma."
5.	Kidney Transplantation 08/01/2015 - "Among 47 MF patients following variants were observed: pilotropic MF (n = 2), follicular mucinosis (n = 1), unilesional MF (n = 1), large-cell transformation (n = 3), erythrodermic MF (n = 1), poikilodermatous MF (n = 2) and posttransplant lymphoproliferative disorder (CD8(+) MF with gamma/delta phenotype after renal transplantation) (n = 1). "