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Alkylating Agents

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Also Known As:
Alkylators; Agent, Alkylating; Agents, Alkylating; Alkylating Agent; Alkylator
Networked: 4128 relevant articles (280 outcomes, 388 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Weller, Michael: 24 articles (03/2020 - 03/2005)
2. Kaina, Bernd: 20 articles (11/2019 - 04/2003)
3. Robison, Leslie L: 17 articles (11/2021 - 07/2006)
4. Hegi, Monika E: 16 articles (01/2018 - 03/2004)
5. Wick, Wolfgang: 15 articles (03/2020 - 12/2005)
6. Stovall, Marilyn: 13 articles (01/2018 - 02/2002)
7. Stupp, Roger: 13 articles (10/2012 - 03/2002)
8. Denny, William A: 12 articles (07/2013 - 03/2002)
9. Hudson, Melissa M: 11 articles (11/2021 - 07/2002)
10. Reifenberger, Guido: 11 articles (03/2020 - 12/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Glioblastoma (Glioblastoma Multiforme)
3. Glioma (Gliomas)
4. Breast Neoplasms (Breast Cancer)
5. Multiple Myeloma

Related Drugs and Biologics

1. Temozolomide (Temodar)
2. DNA (Deoxyribonucleic Acid)
3. Cyclophosphamide (Cytoxan)
4. Melphalan (Alkeran)
5. Ifosfamide
6. Methyltransferases
7. Chlorambucil (Leukeran)
8. Doxorubicin (Adriamycin)
9. Steroids
10. Adrenal Cortex Hormones (Corticosteroids)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Radiotherapy
4. Combination Drug Therapy (Combination Chemotherapy)
5. Adjuvant Chemotherapy