Alkaloids

Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)

Networked: 1065 relevant articles (45 outcomes, 110 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gardner, Dale R: 10 articles (06/2015 - 02/2006)
2.	Panter, Kip E: 10 articles (12/2013 - 11/2004)
3.	Welch, Kevin D: 9 articles (12/2015 - 02/2009)
4.	Green, Benedict T: 9 articles (06/2015 - 02/2009)
5.	Wink, Michael: 8 articles (11/2015 - 01/2007)
6.	Lee, Stephen T: 8 articles (12/2013 - 01/2007)
7.	Pfister, James A: 7 articles (06/2015 - 12/2007)
8.	Cook, Daniel: 7 articles (06/2015 - 01/2007)
9.	Hong, Zhenfeng: 6 articles (07/2015 - 04/2010)
10.	Zhao, Jinyan: 6 articles (07/2015 - 04/2010)

Related Diseases

1.	Neoplasms (Cancer) 12/01/1990 - "These and related alkaloids have been the subject of many pharmacological and biochemical investigations both in vivo and in vitro in the search for improved cancer treatments. " 01/01/2016 - "Although the therapeutic potentials of steroidal alkaloids look promising in the preclinical and clinical studies, further pharmacokinetic and clinical studies are mandated to define their efficacy and safety in cancer and other diseases. " 02/01/2015 - "To study the alkaloids of Macleaya cordata and their anti-tumor activities. " 01/01/2015 - "Chemical studies on the Calycanthaceae have led to the discovery of about 14 alkaloids of different skeletons, including dimeric piperidinoquinoline, dimeric pyrrolidinoindoline and/or trimeric pyrrolidinoindolines, which exhibit significant anti-convulsant, anti-fungal, anti-viral analgesic, anti-tumor, and anti-melanogenesis activities. " 11/01/2014 - "As such, the goal of the present study was to investigate and evaluate the effect of total alkaloids in Rubus alceifolius Poir (TARAP) on tumor angiogenesis and investigate the underlying molecular mechanisms of TARAP action in vivo and in vitro. "
2.	Brain Ischemia (Cerebral Ischemia) 01/01/2012 - "Some studies have reported that the phenolic alkaloids of Menispermum dauricum rhizome (PAM) have protective effects against brain ischemia injury, but the mechanism of this action remains to be clarified. " 08/01/2004 - "To study the protective effects of phenolic alkaloids from Menispermum dauricum (PAMd) on inflammatory injury following focal cerebral ischemia-reperfusion in rats. " 08/01/2004 - "[Protective effects of phenolic alkaloids from Menispermum dauricum on inflammatory injury following focal cerebral ischemia-reperfusion in rats]." 01/01/2012 - "Phenolic alkaloids from Menispermum dauricum rhizome protect against brain ischemia injury via regulation of GLT-1, EAAC1 and ROS generation." 01/01/2005 - "[Effects of Corydalis ambailis migo total alkaloids on experimental cerebral ischemia]."
3.	Ischemia 01/28/2007 - "To investigate the protective effects and possible mechanisms of Veratrum nigrum L.var. ussuriense Nakai alkaloids (VnA) on hepatic ischemia/reperfusion (I/R) injury in rats. " 01/01/2015 - "Isocorynoxeine, one of the major alkaloids from Uncaria Hook, shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. " 09/01/2014 - "Isorhynchophylline is one of the major alkaloids from the Uncaria hook possessing the effects of lowered blood pressure, vasodilatation and protection against ischemia-induced neuronal damage. " 01/01/1992 - "Our data indicate, that hypothermia significantly inhibits neuronal injury as well as post-ischemic alkaloids and astrocytosis, induced by 15 min of forebrain ischemia in the rat." 12/03/2004 - "In this study we examined the protective effects of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus and interaction of these alkaloids with neurotransmitter receptors in a receptor expression model of Xenopus oocytes. "
4.	Hypertension (High Blood Pressure) 02/06/1959 - "[Selected alkaloids of Rauwolfia useful in the treatment of arterial hypertension]." 07/01/1956 - "[Rauwolfia serpentina alkaloids in hypertension in pregnancy]." 11/19/1955 - "[Treatment of arterial hypertension with total alkaloids of Rauwolfia serpentina or sarpagandah]." 10/01/1955 - "[Use of total Rauwolfia serpentina alkaloids in senile hypertension of women; clinical and electrocardiographic aspects]." 08/12/1955 - "[The treatment of essential hypertension with Rauwolfia serpentina alkaloids (Rauwolfon Jura)]."
5.	Infection 11/01/2005 - "The results suggest that certain of the skin alkaloids of poison frogs, in addition to being noxious to predators, may also benefit the frog through protection against skin infections." 01/01/2010 - "However, most studies to date have involved agronomic grasses and often consider only infection status (infected vs. uninfected), without explicitly measuring endophyte-produced alkaloids, which vary among endophyte isolates and may impact consumers. " 10/01/2014 - "The characteristic of the host tegument, such as the presence of alkaloids, could significantly contribute to the low occurrence of infection by skin-penetrating nematodes. " 03/01/2014 - "These modulators can be chemically synthesized or isolated from natural sources (e.g., plant alkaloids) and might also be used in the treatment of fungal infections. " 01/01/2014 - "pastures and have limited effect on the incidence of endophyte infection, persisting endophyte-infected tall fescue will have higher concentrations of toxic alkaloids which may exacerbate fescue toxicosis. "

Related Drugs and Biologics

1.	Flavonoids
2.	rhyncophylline
3.	Terpenes (Terpenoids)
4.	Saponins
5.	Vincristine (Oncovin)
6.	Polysaccharides
7.	Codeine (Codeine Phosphate)
8.	Anti-Bacterial Agents (Antibiotics)
9.	P-Glycoprotein
10.	matrine

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Rectal Administration
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration