Aleutian Mink Disease

A slow progressive disease of mink caused by the ALEUTIAN MINK DISEASE VIRUS. It is characterized by poor reproduction, weight loss, autoimmunity, hypergammaglobulinemia, increased susceptibility to bacterial infections, and death from renal failure. The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible.

Also Known As:

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Interstitial Lung Diseases (Interstitial Lung Disease)
2.	Starvation
3.	Scurvy (Scorbutus)
4.	Systemic Scleroderma (Systemic Sclerosis)
5.	Protein Deficiency

Experts

1.	Zhao, Jianjun: 1 article (05/2014)
2.	Hu, Bo: 1 article (05/2014)
3.	Zhang, Lei: 1 article (05/2014)
4.	Wu, Wei: 1 article (05/2014)
5.	Wang, Zhenjun: 1 article (05/2014)
6.	Zhang, Hailing: 1 article (05/2014)
7.	Bai, Xue: 1 article (05/2014)
8.	Yan, Xijun: 1 article (05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aleutian Mink Disease:

1.	DNA (Deoxyribonucleic Acid)IBA 01/01/1988 - "DNA from one cell culture-adapted and two pathogenic strains of Aleutian disease of mink parvovirus (ADV) was molecularly cloned into the vectors pUC18 and pUC19. " 01/01/1987 - "Analysis of molecularly cloned DNA reveals minor differences among three virus strains of Aleutian disease of mink parvovirus. " 08/01/1975 - "[DNA and antibodies to DNA in Aleutian mink disease]." 01/01/1987 - "A 7- to 95-map unit segment of DNA from Aleutian disease of mink parvovirus (ADV) was subcloned into a bacteriophage SP6 based transcription vector and used to produce radiolabeled viral RNA transcripts corresponding to either 'plus' or 'minus' sense. "
2.	Immunoglobulin G (IgG)IBA 01/01/1984 - "Much of the increased IgG in Aleutian disease of mink is viral antibody." 01/01/1972 - "[Determination of serum IgG as a diagnostic test for Aleutian mink disease]." 10/01/1981 - "Thus, male mink with secondary infertility have (a) higher prevalence and levels of anti-sperm antibody when compared with animals with primary infertility, and the antibody prevalence varies with fur color; (b) severe monocytic orchitis (47%) and/or aspermatogenesis (75%) with negative cultures for bacterial, fungal, mumps, or Coxsackie B viral organisms; (c) massive and extensive granular deposits of mink IgG and/or C3 (71%), typical of immune complexes, along the basal lamina of seminiferous tubules; (d) testes that when eluted with buffer or low pH yielded IgG that was 10-fold enriched in anti-sperm antibody activity as compared with serum IgG; and (e) no immunopathologic evidence of Aleutian mink disease. "
3.	Antigen-Antibody Complex (Immune Complex)IBA 05/12/2014 - "Aleutian mink disease (mink plasmacytosis) is a very severe immune-complex-mediated disease affecting minks. " 06/01/1994 - "Aleutian mink disease (AD) has been characterized by immune complex glomerulonephritis associated with persistent infection of Aleutian mink disease parvovirus (ADV). " 10/01/1981 - "Thus, male mink with secondary infertility have (a) higher prevalence and levels of anti-sperm antibody when compared with animals with primary infertility, and the antibody prevalence varies with fur color; (b) severe monocytic orchitis (47%) and/or aspermatogenesis (75%) with negative cultures for bacterial, fungal, mumps, or Coxsackie B viral organisms; (c) massive and extensive granular deposits of mink IgG and/or C3 (71%), typical of immune complexes, along the basal lamina of seminiferous tubules; (d) testes that when eluted with buffer or low pH yielded IgG that was 10-fold enriched in anti-sperm antibody activity as compared with serum IgG; and (e) no immunopathologic evidence of Aleutian mink disease. "
4.	Viral RNAIBA 01/01/1987 - "A 7- to 95-map unit segment of DNA from Aleutian disease of mink parvovirus (ADV) was subcloned into a bacteriophage SP6 based transcription vector and used to produce radiolabeled viral RNA transcripts corresponding to either 'plus' or 'minus' sense. "
5.	Indicators and Reagents (Reagents)IBA 04/01/1994 - "These new reagents may be useful to analyze cellular basis of the abnormal immune responses observed in Aleutian mink disease, a classical model of human autoimmune diseases."
6.	gamma-Globulins (gamma-Globulin)IBA 06/01/1965 - "METABOLISM AND FUNCTION OF GAMMA GLOBULIN IN ALEUTIAN DISEASE OF MINK."
7.	Freund's AdjuvantIBA 04/01/1971 - "It is concluded that the injection of Freund's adjuvant, under the experimental conditions described, produced lesions which were readily distinguishable from the lesions characteristic of aleutian disease of mink."
8.	Complement System Proteins (Complement)IBA 11/01/1971 - "Aleutian disease of mink: detection of large quantities of complement-fixing antibody to viral antigen."
9.	AntigensIBA 11/01/1971 - "Aleutian disease of mink: detection of large quantities of complement-fixing antibody to viral antigen."
10.	AntibodiesIBA 08/01/1975 - "[DNA and antibodies to DNA in Aleutian mink disease]."