Aleutian Mink Disease

A slow progressive disease of mink caused by the ALEUTIAN MINK DISEASE VIRUS. It is characterized by poor reproduction, weight loss, autoimmunity, hypergammaglobulinemia, increased susceptibility to bacterial infections, and death from renal failure. The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible.

Also Known As:

Networked: 21 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Orchitis
2.	Mumps
3.	Infertility (Sterility)
4.	Glomerulonephritis
5.	Autoimmune Diseases (Autoimmune Disease)

Experts

1.	Hu, Bo: 2 articles (01/2016 - 05/2014)
2.	Yan, Xijun: 2 articles (01/2016 - 05/2014)
3.	Zhang, Hailing: 2 articles (01/2016 - 05/2014)
4.	Zhang, Lei: 2 articles (01/2016 - 05/2014)
5.	Brzeziński, Marcin: 1 article (07/2021)
6.	Jankow, Władysław: 1 article (07/2021)
7.	Kołodziej-Sobocińska, Marta: 1 article (07/2021)
8.	Sironen, Tarja: 1 article (07/2021)
9.	Virtanen, Jenni M E: 1 article (07/2021)
10.	Zalewski, Andrzej: 1 article (07/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aleutian Mink Disease:

1.	feralIBA 07/01/2021 - "This study shows that Aleutian mink disease strongly affects feral mink but the spatio-temporal variation of its prevalence is complex and partly related to the transmission of the virus from farmed mink to feral populations. " 07/01/2021 - "Aleutian mink disease: Spatio-temporal variation of prevalence and influence on the feral American mink."
2.	DNA (Deoxyribonucleic Acid)IBA 01/01/1988 - "DNA from one cell culture-adapted and two pathogenic strains of Aleutian disease of mink parvovirus (ADV) was molecularly cloned into the vectors pUC18 and pUC19. " 01/01/1987 - "Analysis of molecularly cloned DNA reveals minor differences among three virus strains of Aleutian disease of mink parvovirus. " 08/01/1975 - "[DNA and antibodies to DNA in Aleutian mink disease]." 01/01/1987 - "A 7- to 95-map unit segment of DNA from Aleutian disease of mink parvovirus (ADV) was subcloned into a bacteriophage SP6 based transcription vector and used to produce radiolabeled viral RNA transcripts corresponding to either 'plus' or 'minus' sense. "
3.	Immunoglobulin G (IgG)IBA 01/01/1984 - "Much of the increased IgG in Aleutian disease of mink is viral antibody." 01/01/1972 - "[Determination of serum IgG as a diagnostic test for Aleutian mink disease]." 10/01/1981 - "Thus, male mink with secondary infertility have (a) higher prevalence and levels of anti-sperm antibody when compared with animals with primary infertility, and the antibody prevalence varies with fur color; (b) severe monocytic orchitis (47%) and/or aspermatogenesis (75%) with negative cultures for bacterial, fungal, mumps, or Coxsackie B viral organisms; (c) massive and extensive granular deposits of mink IgG and/or C3 (71%), typical of immune complexes, along the basal lamina of seminiferous tubules; (d) testes that when eluted with buffer or low pH yielded IgG that was 10-fold enriched in anti-sperm antibody activity as compared with serum IgG; and (e) no immunopathologic evidence of Aleutian mink disease. "
4.	Antigen-Antibody Complex (Immune Complex)IBA 05/12/2014 - "Aleutian mink disease (mink plasmacytosis) is a very severe immune-complex-mediated disease affecting minks. " 06/01/1994 - "Aleutian mink disease (AD) has been characterized by immune complex glomerulonephritis associated with persistent infection of Aleutian mink disease parvovirus (ADV). " 10/01/1981 - "Thus, male mink with secondary infertility have (a) higher prevalence and levels of anti-sperm antibody when compared with animals with primary infertility, and the antibody prevalence varies with fur color; (b) severe monocytic orchitis (47%) and/or aspermatogenesis (75%) with negative cultures for bacterial, fungal, mumps, or Coxsackie B viral organisms; (c) massive and extensive granular deposits of mink IgG and/or C3 (71%), typical of immune complexes, along the basal lamina of seminiferous tubules; (d) testes that when eluted with buffer or low pH yielded IgG that was 10-fold enriched in anti-sperm antibody activity as compared with serum IgG; and (e) no immunopathologic evidence of Aleutian mink disease. "
5.	AntibodiesIBA 01/01/1976 - "Aleutian disease of mink: production of 14C-labeled antiviral antibodies by mink lymphoid cells in vitro." 08/01/1975 - "[DNA and antibodies to DNA in Aleutian mink disease]."
6.	VaccinesIBA 01/01/2021 - "Aleutian mink disease (AMD), which is caused by Aleutian mink disease virus (AMDV), is an important contagious disease for which no effective vaccine is yet available. "
7.	Viral RNAIBA 01/01/1987 - "A 7- to 95-map unit segment of DNA from Aleutian disease of mink parvovirus (ADV) was subcloned into a bacteriophage SP6 based transcription vector and used to produce radiolabeled viral RNA transcripts corresponding to either 'plus' or 'minus' sense. "
8.	Peptides (Polypeptides)IBA 01/01/2016 - "Development of a Peptide ELISA for the Diagnosis of Aleutian Mink Disease."
9.	Indicators and Reagents (Reagents)IBA 04/01/1994 - "These new reagents may be useful to analyze cellular basis of the abnormal immune responses observed in Aleutian mink disease, a classical model of human autoimmune diseases."
10.	ImmunosorbentsIBA 05/01/1982 - "Experiments were undertaken to investigate the potential of the enzyme-linked immunosorbent assay (ELISA) as a screening test for the diagnosis of the 2 known naturally occurring forms of Aleutian disease of mink. " 05/01/1982 - "Detection of antibody in Aleutian disease of mink: comparison of enzyme-linked immunosorbent assay and counterimmunoelectrophoresis."

Therapies and Procedures

1.	Therapeutics 07/01/1975 - "Poly IC therapy in aleutian disease of mink."