Aldehydes

05/15/2003 - "The aims of the present study were (1) to evaluate whether individual aldehydes resulting from lipid peroxidation can be measured in exhaled breath condensate, (2) to assess the influence of sampling procedures on aldehyde concentrations, and (3) to compare aldehyde levels of patients with stable, moderate to severe, chronic obstructive pulmonary disease with those of smoking and nonsmoking control subjects. "
05/15/2003 - "Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease."
01/01/2009 - "In conclusion, increased oxidation of lipids and proteins resulting in a progressive increase in the amount of total plasma carbonyls and oxidative stress the presence of oxidative stress during COPD progression, concomitant with an increased oxidation of lipids and proteins resulting in a progressive and significant increase in the amount of total carbonyls formed from lipid-derived aldehydes and direct amino acid side chain oxidation in plasma, may serve as a biomarker and independent monitor of COPD progression and oxidative stress injury."
05/15/2003 - "Whereas all aldehydes but nonanal were lower in control subjects as compared with other groups, only malondialdehyde distinguished smoking control subjects from patients with chronic obstructive pulmonary disease and could be envisaged as a biomarker potentially useful to monitor the disease and its response to therapy."
05/01/2012 - "A variety of oxidants, free radicals, and carbonyls/aldehydes are implicated in the pathogenesis of COPD, it is therefore, possible that therapeutic administration or supplementation of multiple antioxidants and/or boosting the endogenous levels of antioxidants will be beneficial in the treatment of COPD. "

01/01/2014 - "This study was performed to explore whether Alda-1, a newly identified ALDH2 activator, was able to protect brain against ischemia/reperfusion injury through clearance of reactive aldehydes. "
10/01/2010 - "There is compelling evidence that high concentrations of aldehydes are responsible for much of the damage elicited by cardiac ischemia-reperfusion injury, while sublethal concentrations of aldehydes stimulate stress resistance pathways, to achieve cardioprotection. "
11/01/2005 - "Mass spectrometry studies of myocardial tissue from murine models of acute MI (both chronic left anterior descending coronary artery ligation and ischemia/reperfusion injury) confirmed that MPO serves as a major enzymatic source in the generation of these cytotoxic aldehydes. "
01/01/2014 - "Our results suggest that the protective effect of Alda-1 on cerebral ischemia/reperfusion injury is related to ALDH2 activation and clearance of reactive aldehydes. "
01/01/2014 - "Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes."

09/14/2001 - "The results of these studies demonstrate that some structurally unique adducts are formed from these carcinogenic aldehydes and suggest some new directions for research on the potential role of aldehydes in human cancer."
12/01/2015 - "ALDHs are important in detoxification of aldehydes, amino acid metabolism, embryogenesis and development, neurotransmission, oxidative stress, and cancer. "
10/01/2014 - "Moreover, the aldehydes level and Nrf2 phosphorylation were significantly higher in the stage I than in the stage II. The level of Nrf2 inhibitor - Bach1 was lower in all histological types of tumor, but in AC was the most reduced, what is correlated with the lowest level of reactive aldehydes. "
10/01/2014 - "Tumor tissues showed several times higher reactive aldehydes level and those changes were accompanied by overexpression of Nrf2. "
06/01/2014 - "These findings suggested that any chemicals in CSS, including aldehydes, phosphorylate H3S10 via JNK and PI3K/Akt pathways, which is different from the DNA damage response, resulting in tumor promotion."

10/01/2008 - "Animal studies have shown that increased levels of endogenous aldehydes may lead to hypertension and oxidative stress. "
02/01/1946 - "Observations on renal tissue aldehydes and their possible role in the mechanism of hypertension."
04/01/2010 - "Plasma methylglyoxal and MGH may not represent tissue modification or, alternatively, other tissue AGEs, derived from methylglyoxal or other aldehydes, may be involved in hypertension in this model."
04/01/1998 - "Role of aldehydes in fructose induced hypertension."
01/01/2015 - "Increased clearance of reactive aldehydes and damaged proteins in hypertension-induced compensated cardiac hypertrophy: impact of exercise training."

01/15/2011 - "Alzheimer disease elevates lipid peroxidation in the brain and data indicate that the resulting lipid-aldehydes are pathological effectors of lipid peroxidation. "
01/01/2007 - "Elevated levels of aldehydes were found in Alzheimer's disease (AD). "
12/01/2006 - "An increase in aldehydes has been found in Alzheimer's disease. "
08/01/2007 - "Modification of biomolecules by reactive aldehydes is believed to play a role in biological processes, including aging, atherosclerosis, and Alzheimer's disease. "
05/01/2007 - "Increased levels of unsaturated aldehydes play an important role in the pathogenesis of a number of human diseases such as Alzheimer's disease, atherosclerosis and diabetes. "