HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Aldehyde Dehydrogenase

Subscribe to New Research on Aldehyde Dehydrogenase

An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.

Also Known As:

Aldehyde Dehydrogenase (NAD(+)); Aldehyde Dehydrogenase E1; Aldehyde Dehydrogenase E2; Aldehyde-NAD Oxidoreductase; Aldehyde NAD Oxidoreductase; D Glucuronolactone Dehydrogenase; Dehydrogenase, Aldehyde; Dehydrogenase, D-Glucuronolactone; D-Glucuronolactone Dehydrogenase; Aldehyde:NAD+ oxidoreductase

Networked: 827 relevant articles (22 outcomes, 84 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Oxidoreductases Acting on Aldehyde or Oxo Group Donors
      - Aldehyde Oxidoreductases: 1
        Aldehyde Dehydrogenase: 827
        aldehyde dehydrogenase 1: 357
        bovine corneal protein 54: 31
        human ALDH16A1 protein: 1
        4-sulfobenzaldehyde dehydrogenase
        Arabidopsis ALDH3I1 protein
        Arabidopsis ALDH7B4 protein
        Arabidopsis reduced epidermal fluorescence1 protein
        azoxy procarbazine oxidase
        Bacillus subtilis GbsA protein
        Helicobacter pylori aspartyl semialdehyde dehydrogenase
        human AASDH protein
        human ALDH1A1 protein
        human ALDH1B1 protein
        human ALDH1L1 protein
        human ALDH2 protein
        human ALDH3A1 protein
        human ALDH7A1 protein
        mouse 8S benzo(a)pyrene-binding protein
        mouse aldehyde dehydrogenase 1A1
        mouse aldehyde dehydrogenase 2
        mouse Aldh1a2 protein
        mouse Aldh3a1protein
        mouse DNR-BP54 protein
        mouse gamma-trimethylaminobutyraldehyde dehydrogenase
        omega-Crystallins
        rat 4S benzo(a)pyrene-binding protein
        rat Aldh2 protein
        rat daunorubicin-binding protein
        Sphingomonas macrogoltabidus nicotinoprotein aldehyde dehydrogenase
        Taeniopygia guttata zRalDH protein
        Ustilago maydis indole-3-acetaldehyde dehydrogenase

Experts

1.	Szmitkowski, Maciej: 25 articles (06/2015 - 06/2004)
2.	Jelski, Wojciech: 25 articles (06/2015 - 06/2004)
3.	Wicha, Max S: 11 articles (01/2014 - 11/2007)
4.	Orywal, Karolina: 10 articles (06/2015 - 06/2008)
5.	Mochly-Rosen, Daria: 10 articles (01/2015 - 02/2009)
6.	Vasiliou, Vasilis: 8 articles (01/2016 - 06/2006)
7.	Matsuo, Keitaro: 8 articles (02/2015 - 03/2002)
8.	Kawamoto, Toshihiro: 8 articles (10/2014 - 06/2003)
9.	Ren, Jun: 7 articles (12/2015 - 01/2007)
10.	Sun, Aijun: 6 articles (10/2015 - 01/2013)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 09/01/1993 - "A strong protection against the development of alcoholism is exerted by a point mutation in the gene coding for low Km aldehyde dehydrogenase (ALDH), i.e. " 01/01/1996 - "The present study explored the utility of erythrocyte aldehyde dehydrogenase (ALDH) as a peripheral marker in alcoholism. " 01/01/1988 - "Additional studies also indicate a possible importance of neuropsychological test deficits in higher-risk boys studied in their preteen or early-teen years; information continues to support the importance of the aldehyde dehydrogenase isoenzyme pattern for the alcoholism risk among Orientals, but little consistent information has yet identified other enzyme activity levels or personality profiles as factors significantly different for higher-risk and lower-risk populations. " 06/15/2014 - "DSF is an inhibitor of aldehyde dehydrogenase (ALDH) and an FDA-approved drug for treating alcoholism. " 05/01/2012 - "Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians."
2.	Ischemia 03/01/2012 - "Aldehyde dehydrogenase-bright (ALDH(br)) cells have shown promise in promoting angiogenesis and providing perfusion benefits in preclinical ischemia studies. " 01/01/2015 - "Aldehyde dehydrogenase 2 (ALDH2) plays a crucial role in myocardial protection against ischemia. " 12/01/2011 - "A randomized, controlled study of autologous therapy with bone marrow-derived aldehyde dehydrogenase bright cells in patients with critical limb ischemia." 10/01/2015 - "Recent evidence suggested a vital role of aldehyde dehydrogenase 2 (ALDH2) in cardiac protection after ischemia. " 10/01/2015 - "Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation."
3.	Neoplasms (Cancer) 05/01/2015 - "We searched PubMed for published reviews and original studies on alcohol intake, aldehyde dehydrogenase polymorphisms, and risk for oesophageal cancer in Japan, published before 2014. " 11/01/2012 - "In this study, three widely used markers (aldehyde dehydrogenase (ALDH)1+ and CD24-CD44+) were used to define two populations of CSC in a large cohort of breast cancers. " 03/01/1988 - "To study the mechanism(s) controlling expression of the tumor-associated aldehyde dehydrogenase (tumor ALDH), which appears during rat hepatocarcinogenesis, cDNAs encoding this isozyme were cloned and identified with an antibody probe. " 12/01/1984 - "The resistant hepatocyte model was used to study expression of tumor-associated aldehyde dehydrogenase (ALDH) activity during the course of rat hepatocarcinogenesis. " 10/15/2015 - "We demonstrate that activated NK cells are capable of preferentially killing CSCs identified by multiple CSC markers (CD24(+)/CD44(+), CD133(+), and aldehyde dehydrogenase(bright)) from a wide variety of human cancer cell lines in vitro and dissociated primary cancer specimens ex vivo. "
4.	Inflammation 07/01/2014 - "Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice." 05/30/2011 - "Protein carbonylation and the associated toxicity caused by GO and MGO were studied in the following hepatocyte models: (1) control hepatocytes, (2) glutathione (GSH)-depleted hepatocytes, (3) mitochondrial aldehyde dehydrogenase (ALDH2)-inhibited hepatocytes, (4) hepatocyte inflammation model, and (5) catalase-inhibited hepatocyte model. " 06/05/2015 - "To investigate and compare the protective effects of ferulic acid and related polyphenols against GO- or MGO-induced toxicity, five hepatocyte models were used: (a) control hepatocytes, (b) GSH-depleted hepatocytes, (c) catalase-inhibited hepatocytes, (d) aldehyde dehydrogenase (ALDH2)-inhibited hepatocytes, and (e) hepatocyte inflammation system (a non-toxic H2O2-generating system). " 01/01/2006 - "The gene polymorphisms screened were: alcohol sensitivity-associated polymorphisms of alcohol dehydrogenase (ADH2) Arg47His, aldehyde dehydrogenase (ALDH2) Glu487Lys, smoking sensitivity-associated polymorphisms of glutathione S transferase (GST) M1, (GST)T1, NAD(P)H quinone oxidoreductase 1 (NQO1) C609T, inflammation-associated polymorphisms of interleukin-1beta (IL-1B)T-31C, tumor necrosis factor alpha (TNF-alpha) T-1031C, endothelial constitutive nitric oxide synthase (ecNOS) Glu298Asp, longevity-associated polymorphism of mitochondrial DNA (mtDNA) 5178 A/C, allergy-associated polymorphism of interleukin-4 (IL-4), and immunity-associated polymorphism of CD14. "
5.	Alcoholic Liver Diseases (Alcoholic Liver Disease) 06/01/2015 - "The present study tested the efficacy of Alda-1, a specific aldehyde dehydrogenase 2 (ALDH2) activator, in treating alcoholic liver disease. " 11/01/2003 - "To study the relationship between aldehyde dehydrogenase (ALDH) gene polymorphism and alcoholic liver disease, and investigate the genetic pathogenesis of alcoholic liver disease (ALD). " 01/01/1989 - "Hepatic lipid peroxidation and aldehyde dehydrogenase activity in alcoholic and non alcoholic liver disease." 03/01/1986 - "Actively drinking alcoholics had significantly lower erythrocyte aldehyde dehydrogenase activity than controls (P less than 0.01) but abstaining alcoholic liver disease and non-alcoholic liver disorder subjects did not. " 03/01/1986 - "Erythrocyte aldehyde dehydrogenase activity was assayed in actively drinking alcoholics, patients with alcoholic liver disease who claimed to be abstaining, patients with non-alcoholic liver disorders and normal controls. "

Related Drugs and Biologics

1.	Disulfiram (Antabuse)
2.	Acetaldehyde
3.	aldehyde dehydrogenase 1
4.	Aldehydes
5.	Catalase
6.	Antigens
7.	Insulin (Novolin)
8.	IPI 269609
9.	4-hydroxy-2-nonenal (4-hydroxynonenal)
10.	polyphenols

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Transplantation (Transplant Recipients)
3.	Intramuscular Injections
4.	Oral Administration
5.	Chemoprevention