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Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))

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A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.

Also Known As:

Alcohol Dehydrogenase (NAD+); Alcohol Dehydrogenase I; Alcohol Dehydrogenase II; Alcohol-NAD+ Oxidoreductase; Yeast Alcohol Dehydrogenase; Alcohol Dehydrogenase, Yeast; Alcohol NAD+ Oxidoreductase; Dehydrogenase, Alcohol; Dehydrogenase, Yeast Alcohol; Oxidoreductase, Alcohol-NAD+; Alcohol:NAD+ oxidoreductase

Networked: 545 relevant articles (11 outcomes, 58 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Szmitkowski, Maciej: 31 articles (06/2015 - 07/2002)
2.	Jelski, Wojciech: 30 articles (06/2015 - 07/2002)
3.	Orywal, Karolina: 10 articles (06/2015 - 06/2008)
4.	Chrostek, Lech: 9 articles (08/2008 - 07/2002)
5.	Laniewska-Dunaj, Magdalena: 6 articles (12/2014 - 09/2011)
6.	Seitz, Helmut K: 5 articles (01/2015 - 04/2006)
7.	Zalewski, Bogdan: 5 articles (09/2008 - 06/2004)
8.	Matsuo, Keitaro: 4 articles (02/2015 - 05/2007)
9.	Tolstrup, Janne S: 4 articles (01/2014 - 08/2008)
10.	Szmitkowski, M: 4 articles (01/2013 - 01/2002)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 07/01/2002 - "Variants of different Class I alcohol dehydrogenase (ADH) genes have been shown to be associated with an effect that is protective against alcoholism. " 01/01/2010 - "Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model." 11/01/2004 - "Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism." 12/01/2002 - "The alcohol dehydrogenase (ADH) genes have been repeatedly associated with protection against alcoholism. " 05/01/2011 - "This study sets out to examine the distribution of the frequencies of alleles that encode alcohol dehydrogenase with different metabolization rates, as higher rates make for greater susceptibility to alcoholism. "
2.	Poisoning 09/01/1980 - "Effect of chronic alcoholic poisoning on the activity of alcohol dehydrogenase (ADH) in the liver of rats was studied during ontogenesis. " 07/01/1987 - "Finally, the current studies may prove beneficial in the treatment of acute glycol ethers poisoning with alcohol dehydrogenase inhibitors." 02/01/2015 - "In the absence of severe poisoning but if the methanol concentration is elevated and there is adequate alcohol dehydrogenase blockade, extracorporeal treatment is not immediately required. " 02/01/2003 - "In both admissions, she was treated with fomepizol (4-MP), a newly available alcohol dehydrogenase antagonist for treatment of ethylene glycol poisoning." 02/08/2001 - "The inhibition of alcohol dehydrogenase is fundamental to the treatment of methanol poisoning. "
3.	Hepatocellular Carcinoma (Hepatoma) 12/01/1995 - "Expression of the class I alcohol dehydrogenase (ADH) gene in the rat hepatoma microcell hybrid cell line, 11-3, was examined. " 12/01/1995 - "The class I alcohol dehydrogenase gene is glucocorticoid-responsive in the rat hepatoma microcell hybrid cell line, 11-3." 08/20/1995 - "Using the human hepatocellular carcinoma cell line, Hep G2, we have constructed an hepatic cell line that stably expresses alcohol dehydrogenase. " 11/01/1991 - "Properties of serum alcohol dehydrogenase in Nigerians with primary hepatoma." 09/01/1990 - "trans activation of human alcohol dehydrogenase gene expression in hepatoma cells by C/EBP molecules bound in a novel arrangement just 5' and 3' to the TATA box."
4.	Insulin Resistance 01/01/1996 - "In this study, we used the euglycaemic hyperinsulinaemic clamp to examine the role that hepatic ethanol oxidation via alcohol dehydrogenase (ADH) plays in the acute insulin resistance caused by ethanol in the rat. " 10/20/2015 - "Only slow ethanol metabolizers (alcohol dehydrogenase alleles [ADH1B1] carriers) significantly benefited from the effect of both wines on glycemic control (fasting plasma glucose, homeostatic model assessment of insulin resistance, and hemoglobin A1c) compared with fast ethanol metabolizers (persons homozygous for ADH1B2). "
5.	Polydactyly (Polydactylism) 08/01/1985 - "In particular all three agents produced unusual heart defects (dilated ductus arteriosus and dilated aortic arch) not seen with other agents, as well as ventral polydactyly, a rarely seen defect, suggesting teratogenic action by a common mechanism or component; 4-methylpyrazole, an alcohol dehydrogenase inhibitor, provided significant protection against 2-ME. "

Related Drugs and Biologics

1.	Ethanol (Ethyl Alcohol)
2.	fomepizole (Antizol)
3.	Ethylene Glycol (Monoethylene Glycol)
4.	Acetaldehyde
5.	Hemoglobins (Hemoglobin)
6.	Ethers
7.	Methanol (Carbinol)
8.	Glucose (Dextrose)
9.	tauroursodeoxycholic acid
10.	Mercaptoethanol (2 Mercaptoethanol)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Length of Stay
3.	Intravenous Injections
4.	Oral Administration