Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))

A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.

Also Known As:

Alcohol Dehydrogenase (NAD+); Alcohol Dehydrogenase I; Alcohol Dehydrogenase II; Alcohol-NAD+ Oxidoreductase; Yeast Alcohol Dehydrogenase; Alcohol Dehydrogenase, Yeast; Alcohol NAD+ Oxidoreductase; Dehydrogenase, Alcohol; Dehydrogenase, Yeast Alcohol; Oxidoreductase, Alcohol-NAD+; Alcohol:NAD+ oxidoreductase

Networked: 819 relevant articles (18 outcomes, 89 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jelski, Wojciech: 48 articles (01/2022 - 07/2002)
2.	Szmitkowski, Maciej: 45 articles (07/2018 - 07/2002)
3.	Orywal, Karolina: 28 articles (01/2022 - 06/2008)
4.	Banta, Scott: 10 articles (06/2019 - 09/2009)
5.	Chrostek, Lech: 9 articles (08/2008 - 07/2002)
6.	Wall, Tamara L: 8 articles (01/2016 - 01/2003)
7.	Kaphalia, Bhupendra S: 7 articles (01/2022 - 07/2006)
8.	Werel, Tadeusz: 7 articles (03/2018 - 06/2015)
9.	Laniewska-Dunaj, Magdalena: 7 articles (03/2017 - 09/2011)
10.	Ehlers, Cindy L: 7 articles (12/2014 - 01/2003)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 05/08/1998 - "Multipoint methods provided the strongest suggestions of linkage with susceptibility loci for alcohol dependence on chromosomes 1 and 7, and more modest evidence for a locus on chromosome 2. In addition, there was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations." 07/01/2002 - "Variants of different Class I alcohol dehydrogenase (ADH) genes have been shown to be associated with an effect that is protective against alcoholism. " 01/01/2007 - "Previous studies have found that a variant of the alcohol dehydrogenase (ADH) gene (ADH1B*47His) is associated with protection against alcohol dependence in Māori. " 01/01/2010 - "Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model." 11/01/2004 - "Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism."
2.	Hypoxia (Hypoxemia) 06/01/1992 - "Although soil waterlogging significantly increased alcohol dehydrogenase activity (ADH) after 30 h, significant increase in central air space by 45-50% of the cross-sectional stem area eliminated root hypoxia, and ADH activity decreased to levels equivalent to drained controls after 42 days. " 01/01/2023 - "indica, we determined that hypoxia-responsive genes, such as those encoding alcohol dehydrogenase (ADH), are highly induced in symbiotic D. " 05/01/2021 - "In contrast to DcSUS1 (Dca4507.1), a SUS gene already reported in carnation, which showed preferential expression under aerated conditions, the expression of DcSUS2 (Dca22218.1), an undescribed carnation SUS gene, was enhanced under hypoxia similarly to an alcohol dehydrogenase gene DcADH1 (Dca18671.1). " 07/01/2018 - "The genes encoding the plant alcohol dehydrogenase (ADH-P) were induced when suffering hypoxia. " 12/01/2010 - "The goldfish is one of the few vertebrates showing strong enzymatic plasticity for the expression of alcohol dehydrogenase (ADH), which allows it to survive long periods of severe anoxia. "
3.	Poisoning 09/01/1980 - "Effect of chronic alcoholic poisoning on the activity of alcohol dehydrogenase (ADH) in the liver of rats was studied during ontogenesis. " 07/01/1987 - "Finally, the current studies may prove beneficial in the treatment of acute glycol ethers poisoning with alcohol dehydrogenase inhibitors." 01/01/2022 - "Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review." 01/01/2017 - "We report a prediction model for the duration of high-efficiency HD sessions based retrospectively on a cohort study of 26 cases of acute ethylene glycol poisoning in 24 individuals treated by alcohol dehydrogenase competitive inhibitors, cofactors and HD. " 03/01/2016 - "These poisonings have traditionally been treated with ethanol since it competes for the active site of alcohol dehydrogenase and decreases the formation of toxic metabolites. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/1995 - "Expression of the class I alcohol dehydrogenase (ADH) gene in the rat hepatoma microcell hybrid cell line, 11-3, was examined. " 08/20/1995 - "Using the human hepatocellular carcinoma cell line, Hep G2, we have constructed an hepatic cell line that stably expresses alcohol dehydrogenase. " 11/01/1991 - "Properties of serum alcohol dehydrogenase in Nigerians with primary hepatoma." 09/01/1990 - "trans activation of human alcohol dehydrogenase gene expression in hepatoma cells by C/EBP molecules bound in a novel arrangement just 5' and 3' to the TATA box." 05/15/1988 - "Liver alcohol dehydrogenase activity was present in rat H4IIE hepatoma cells. "
5.	Insulin Resistance 01/01/1996 - "In this study, we used the euglycaemic hyperinsulinaemic clamp to examine the role that hepatic ethanol oxidation via alcohol dehydrogenase (ADH) plays in the acute insulin resistance caused by ethanol in the rat. " 10/20/2015 - "Only slow ethanol metabolizers (alcohol dehydrogenase alleles [ADH1B1] carriers) significantly benefited from the effect of both wines on glycemic control (fasting plasma glucose, homeostatic model assessment of insulin resistance, and hemoglobin A1c) compared with fast ethanol metabolizers (persons homozygous for ADH1B2). " 06/02/2009 - "We report for the first time candidate athletic-performance genes within regions targeted by selection in Thoroughbred horses that are principally responsible for fatty acid oxidation, increased insulin sensitivity and muscle strength: ACSS1 (acyl-CoA synthetase short-chain family member 1), ACTA1 (actin, alpha 1, skeletal muscle), ACTN2 (actinin, alpha 2), ADHFE1 (alcohol dehydrogenase, iron containing, 1), MTFR1 (mitochondrial fission regulator 1), PDK4 (pyruvate dehydrogenase kinase, isozyme 4) and TNC (tenascin C). "

Related Drugs and Biologics

1.	Ethanol (Ethyl Alcohol)
2.	Fomepizole (Antizol)
3.	Aldehyde Dehydrogenase
4.	Acetaldehyde
5.	Reactive Oxygen Species (Oxygen Radicals)
6.	Oxidoreductases (Dehydrogenase)
7.	Catalase
8.	aldehyde dehydrogenase (NAD(P)+) (acetaldehyde dehydrogenase)
9.	Hemoglobins (Hemoglobin)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Glycemic Control
2.	Renal Dialysis (Hemodialysis)
3.	Therapeutics
4.	Ligation
5.	Length of Stay