Alanine (L-Alanine)

A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.

Also Known As:

Networked: 2577 relevant articles (53 outcomes, 184 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Karlsson, Oskar: 8 articles (03/2015 - 06/2011)
2.	Brittebo, Eva B: 7 articles (03/2015 - 06/2011)
3.	Uchida, Shinichi: 6 articles (12/2015 - 11/2010)
4.	Ilag, Leopold L: 6 articles (05/2015 - 06/2012)
5.	van der Maarel, Silvère M: 6 articles (04/2014 - 04/2010)
6.	Raz, Vered: 6 articles (04/2014 - 01/2011)
7.	Vigneron, Daniel B: 6 articles (02/2014 - 06/2006)
8.	Kurhanewicz, John: 6 articles (01/2014 - 06/2006)
9.	Schwarz, Elisabeth: 5 articles (11/2015 - 02/2008)
10.	Wu, Guoyao: 5 articles (08/2015 - 01/2010)

Related Diseases

1.	Body Weight (Weight, Body) 07/01/2009 - "Donor hepatocytes engrafted into iMSUD recipient liver, increased liver BCKDH activity, improved blood total BCAA/alanine ratio, increased body weight at weaning, and extended the lifespan of HTx-treated iMSUD mice compared to phosphate-buffered saline (PBS)-treated and untreated iMSUD mice. " 06/01/1997 - "Next, on 3 trials, the rats were given 15 min access to 0.3 M l-alanine and then injected with LiCl (0.15 M, 1.33 ml/100 g body weight ip). " 08/01/2002 - "The correlation coefficient between total 13CO2 output over 15 min after L-[1-(13)C]alanine administration and liver weight/body weight was 0.902 (P < 0.0001). " 10/01/1999 - "The alanine-SDS electrophoretic method was employed to examine changes in the MHC composition of IF, PYR, CRU and SAR muscles with the ontogenetic growth of the toad from post-natal life (body weight < 1 g) to late adulthood (body weight 200-450 g). " 03/01/1994 - "Following an overnight fast, alanine was infused at a rate of 2 mmol/(h.kg body weight [BW]). "
2.	Ischemia 12/15/2015 - "Hyperpolarized (13)C MRS was also used to examine alanine production during ischemia, which is observed in ex vivo models, but no significant change was noted; metrics incorporating [1-(13)C]alanine did not substantially improve the discrimination of ischemic-reperfused myocardium from nonischemic myocardium. " 02/01/1983 - "Alanine accumulating during ischemia is not glycolytic in origin but occurs through a concerted operation of anaplerotic reactions and tricarboxylic acid cycle metabolite disposal. " 01/01/2012 - "Increased plasma alanine and aspartate aminotransferase activities due to ischemia-reperfusion treatment tended to decrease, and a significant reduction was observed by HAS feeding when compared with the control group. " 11/01/2014 - "Rats in IIR and the two treatment groups were subjected to intestine ischemia for 60 min and those in the treatment groups were administered orally with Ala-Gln or alanine (Ala) respectively. " 01/01/2012 - "Systematic evaluation of this model by performing different ischemia and reperfusion times revealed a close correlation of hepatic ischemia time with liver damage as measured by alanine (ALT) and aspartate (AST) aminotransferase serum levels. "
3.	Anoxia (Hypoxia) 04/01/1988 - "Alanine concentration in the plasma of fetuses subjected to hypoxia significantly increased within 24 h of exposure (0.28 +/- 0.10 vs 0.58 +/- 0.39 mmol/l; P less than 0.01) and remained elevated for the duration of the study. " 01/01/2016 - "It was found that metabolite markers of hypoxic adaptation, such as alanine and tricarboxylic acid intermediates, accumulated in P07 plants under control conditions at similar rates to WT plants under hypoxia. " 10/01/2014 - "Ectopic expression of CaRLK1 enhances hypoxia tolerance with increasing alanine production in Nicotiana spp." 10/01/2010 - "Our results show a role for AlaAT in the catabolism of alanine during the initial period of re-oxygenation following hypoxia. " 03/01/2008 - "It was concluded that the acceleration of alcohol fermentation and the accumulation of alanine were in favor of the enhancement of root zone hypoxia tolerance of cucumber roots."
4.	Inflammation 08/20/2012 - "Herein, we present a switchable, biased-like SDF-1α variant, AAV-[S4V]-SDF-1α, whose distinct activity is coupled to the inflammation-associated presence of dipeptidylpeptidase-4 (DPP-4), which cleaves an alanine-alanine dipeptide from the precursor. " 07/01/2003 - "GAL challenge after ethanol pre-treatment significantly raised serum alanine aminotransaminase (ALT) levels and enhanced liver inflammation when compared with the controls (GAL alone). " 07/01/2015 - "Treatment with Yinchenhao decoction significantly reversed the ConA-induced changes in immunoregulatory gene expression in the liver tissues, reduced serum alanine aminotranferease activity, enhanced serum albumin level, and attenuated the extent of liver inflammation and necrosis. " 04/01/2014 - "HGF ameliorated the liver inflammation during viral hepatitis as alanine transferase, intrahepatic lymphocytes, and splenocyte counts were diminished by HGF. " 01/01/2007 - "Alanine-glutamine dipeptide (AGD) inhibits expression of inflammation-related genes in hemorrhagic shock."
5.	Infection 06/01/2015 - "In this study, the role of two conserved histidines (His490 and His621, located in domains II and III of E2, respectively) in HCV infection was evaluated in the context of JFH-1-based HCVcc using alanine substitutions. " 05/24/2013 - "Alanine mutation and docking studies strongly suggest that the dimer interface could be a potential target for anti-infection drug discovery." 09/01/2015 - "Individual alanine substitutions of two basic residues within the 40s' loop, K42 and R43, abrogated the ability of XCL1 to bind to the viral envelope and block HIV-1 infection; moreover, a loss of HIV-inhibitory function, albeit less marked, was seen upon individual mutation of three additional basic residues: R18, R35, and K46. " 08/01/2015 - "Substitution of Thr-395 with alanine (T395A) only moderately impaired virus cell-to-cell movement and systemic infection. " 01/01/2014 - "A Salmonella dalS mutant defective for D-alanine import was more susceptible to killing by DAO through exposure to greater oxidative stress during infection. "

Related Drugs and Biologics

1.	Transferases
2.	Aspartic Acid (Aspartate)
3.	Lactic Acid
4.	Aspartate Aminotransferases (Aspartate Transaminase)
5.	Glycine (Aminoacetic Acid)
6.	Alkaline Phosphatase
7.	Valine (L-Valine)
8.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
9.	Urea (Carbamide)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Total Parenteral Nutrition
2.	Fluid Therapy (Oral Rehydration Therapy)
3.	Oral Administration
4.	Drug Therapy (Chemotherapy)
5.	Rewarming