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Ajmaline (Wolfina)

An alkaloid found in the root of Rauwolfia serpentina, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.

Also Known As:

Wolfina; Lorajmine; ASTA Medica Brand of Ajmaline; Aritmina; Cardiorythmine; Forest Brand of Ajmaline; Gilurtymal; Giulini Brand of Ajmaline; Lacer Brand of Ajmaline; Protea Brand of Ajmaline; Rauverid; Serenol; Servier Brand of Ajmaline; Solvay Brand of Ajmaline; Tachmalin; Ajmaline Forest Brand; Ajmaline Giulini Brand; Ajmaline Lacer Brand; Ajmaline Protea Brand; Ajmaline Servier Brand; Ajmaline Solvay Brand; Ajmalan-17,21-diol, (17R,21alpha)-

Networked: 303 relevant articles (17 outcomes, 26 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Brugada, Pedro: 14 articles (03/2014 - 01/2004)
2.	Sarkozy, Andrea: 8 articles (03/2014 - 11/2005)
3.	Chierchia, Gian-Battista: 7 articles (03/2014 - 01/2010)
4.	de Asmundis, Carlo: 5 articles (03/2014 - 01/2010)
5.	Batchvarov, Velislav N: 5 articles (11/2011 - 05/2009)
6.	Behr, Elijah R: 5 articles (11/2011 - 05/2009)
7.	Brugada, Ramon: 5 articles (08/2008 - 01/2004)
8.	Brugada, P: 4 articles (10/2014 - 02/2000)
9.	Govindan, Malini: 4 articles (12/2010 - 05/2009)
10.	Borggrefe, Martin: 4 articles (10/2009 - 04/2002)

Related Diseases

1.	Cardiac Arrhythmias (Arrythmia) 01/01/1986 - "Ajmaline infusion produced in 40% of the cases a total suppression and in 100% a significant improvement of malignant ventricular arrhythmia. " 07/01/1990 - "LV diastolic filling is improved after acute application of ajmaline in patients with CAD and normal systolic function; its application may be advised not only for therapy of arrhythmia but also to improve left ventricular diastolic mechanics in these patients." 04/01/1989 - "Pharmacokinetics and antiarrhythmic efficacy of intravenous ajmaline in ventricular arrhythmia of acute onset." 04/01/1975 - "The antiarrhythmic efficacy of ajmaline has been evaluated in three experimental models of cardiac arrhythmias in the dog. " 12/02/1963 - "[CLINICAL STUDIES ON THE THERAPEUTIC VALUE OF AJMALINE IN CARDIAC ARRHYTHMIAS]."
2.	Ventricular Tachycardia 12/01/1969 - "[A case of ventricular tachycardia treated successfully with ajmaline]." 05/01/1985 - "Efficacy of intravenous ajmaline in ventricular tachycardia." 01/01/2015 - "Ajmaline-induced sustained ventricular tachycardia occurred in one patient with BrP, who finally received an ICD. " 09/01/2013 - "Here, we present a rare case of monomorphic ventricular tachycardia, which was observed during the ajmaline challenge test. " 09/01/2013 - "[Monomorphic ventricular tachycardia during the ajmaline test]."
3.	Tachycardia (Tachyarrhythmias) 06/01/1980 - "Long-term oral therapy with ajmaline has proved effective in preventing recurrent tachyarrhythmias. " 12/01/2004 - "Ajmaline is a class Ia anti-arrhythmic drug used in several European countries and Japan as first-line treatment for ventricular tachyarrhythmia. " 01/19/2001 - "The aims of the present study were (1) to determine whether ajmaline administration modifies the rate-dependent properties of the AV node and (2) to correlate these changes with the actions of ajmaline on an in vitro model of AV re-entrant tachycardia. " 04/01/2000 - "At the electrophysiology study, a prolonged HV interval was observed at baseline, and the tachycardia could be reproduced after ajmaline infusion. " 02/01/2013 - "Re-entry tachycardia occurred a second time six days after ablation, and as before, it was stopped only with ajmaline. "
4.	Wolff-Parkinson-White Syndrome (Wolf-Parkinson-White Syndrome) 06/01/1980 - "We conclude that ajmaline is specifically effective and safe in the treatment of the WPW syndrome." 01/01/1989 - "In a patient with the Wolff-Parkinson-White syndrome, the existence of dual accessory pathways, both right-sided, was suspected during ajmaline test and confirmed during electrophysiologic study. " 04/01/1986 - "Comparison of exercise and ajmaline tests with electrophysiologic study in the Wolff-Parkinson-White syndrome." 06/01/1980 - "Ajmaline in WPW syndrome: an electrophysiologic study." 02/01/2013 - "Since electrocardiography showed a delta-wave, Wolff-Parkinson-White (WPW) syndrome was diagnosed, ajmaline prescribed and radio-frequency catheter ablation of three accessory pathways carried out one week later. "
5.	Myocardial Infarction 11/01/1982 - "Seven patients with right precordial Q waves (RPQs) simulating anterior myocardial infarction (MI), but without a previous history of either MI or other underlying diseases showing RPQ, were injected intravenously with ajmaline. " 11/01/1982 - "Effects of ajmaline on right precordial Q waves simulating myocardial infarction." 09/01/1982 - "On the other hand, in 43 Ajmaline tests without VT in patients with myocardial infarction, 6 cases of VT and 1 lethal VF were later observed. " 09/01/1982 - "--Three other cases of abnormal ventricular excitability complicating the administration of 1 mg/kg of Ajmaline to test for paroxysmal block after myocardial infarction. " 09/01/1993 - "As yet the antiarrhythmic efficacy of ajmaline with regard to suppressing the induction of sustained ventricular tachycardia after myocardial infarction has not been determined. "

Related Drugs and Biologics

1.	Lidocaine (Xylocaine)
2.	Procainamide (Procan)
3.	Propafenone (Rythmol)
4.	Propranolol (Inderal)
5.	Antibodies
6.	Aconitine
7.	Oxprenolol (Trasicor)
8.	Isoproterenol (Isoprenaline)
9.	Ajmaline (Wolfina)
10.	Flecainide (Tambocor)

Related Therapies and Procedures

1.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
2.	Intravenous Injections
3.	Electric Countershock (Cardioversion)
4.	Ligation
5.	Injections