Agranulocytosis (Granulocytopenia)

03/01/1995 - "Presented here is a case of clozapine overdose treated successfully with supportive care in which agranulocytosis did not develop."
09/01/1999 - "The atypical antipsychotic agent clozapine is known to be effective in schizophrenic patients refractory to other medications; however, it induces agranulocytosis in approximately 1-2%. "
05/01/2011 - "Evidence of efficacy for psychosis and safety for motor side effects is strongest for clozapine but routine use of clozapine is limited by its potential to cause agranulocytosis and the stringent monitoring requirements. "
09/14/2006 - "Thus functional data derived from the in vitro stromal system defined in these studies may enable further investigation of the mechanisms subserving stromal impairment in clozapine-induced agranulocytosis and direct attention to improved methods for its prevention."
12/01/1996 - "Clozapine does not constitute a first-line treatment due to the occurrence of agranulocytosis. "

05/01/1994 - "G-CSF is effective for patients with granulocytopenia after AC bypass surgery, but we need more experiences to know the best way of administration."
08/01/2009 - "We concluded that: (1) conducting a routine complete blood cell count is beneficial in alerting caregivers to the possibility of agranulocytosis; (2) educating patients about the common symptoms of agranulocytosis may contribute to an early diagnosis; (3) providing granulocyte colony-stimulating factor therapy to patients results in good prognosis; and (4) monitoring for cross-reactions between drugs should be performed to prevent further episodes of agranulocytosis."
03/01/2005 - "This study examined whether granulocyte colony-stimulating factor (G-CSF) is beneficial for the treatment of antithyroid drug-induced agranulocytosis. "
04/15/2002 - "Our findings suggest that G-CSF therapy may be beneficial in the management of drug-induced agranulocytosis in elderly patients."
11/08/1993 - "Despite the high cost of the drug, treatment with granulocyte-colony stimulating factor was found to be cost-effective for patients with uncomplicated drug-induced agranulocytosis."

05/01/1995 - "Further studies are warranted to delineate the role of GM-CSF in the treatment of drug-induced agranulocytosis."
03/28/2005 - "Subcutaneous GM-CSF, 400 mug once daily, days 12-19, was added if dose-limiting granulocytopenia was encountered. "
09/01/2001 - "It was concluded that, dose intensification with GM-CSF prophylaxis is benefical in increasing the treatment tolerability by decreasing the intensity of granulocytopenia as well as providing rapid recovery."
02/15/1999 - "The main toxicity was myelosuppression, although the administration of GM-CSF significantly reduced the percentage of patients with Grade 4 granulocytopenia (53% vs. 78%). "
01/01/1999 - "Duration of granulocytopenia (median: 33 days with GM-CSF) versus 35 days with placebo) and frequency of infectious episodes were not significantly influenced by GM-CSF. "

01/01/1994 - "Our results, with others, clearly show that hematopoietic growth factors are effective in severe antithyroid drug-induced agranulocytosis."
03/01/1999 - "Case reports provide promising results with a shortening in the duration of agranulocytosis, a possible reduction in the duration of hospitalisation and the fatality rate in patients treated with haematopoietic growth factors (HGF) compared with historical controls. "
12/01/1994 - "The results demonstrate that patients with a severe granulocytopenia (< 0.1 x 10(9)/l) treated with hematopoietic growth factors had a significantly faster recovery of the peripheral blood granulocytes compared to previous published studies. "
01/01/2006 - "[Haptenic agranulocytosis: treatment with hemopoietic growth factors]."
03/01/2004 - "Long-term outcome of patients treated with hematopoietic growth factors for idiosyncratic drug-induced agranulocytosis."

04/01/2013 - "Despite the fact that this requirement probably saved the life of this patient, this monitoring is not evidence-based because the incidence of agranulocytosis does not exceed that of conventional antipsychotic drugs, for which no such requirement exists. "
06/01/2009 - "Nevertheless, second-generation antipsychotics may also lead to adverse events such as metabolic disorders, agranulocytosis or muscle damage. "
01/01/2006 - "The model should help us to understand how agranulocytosis can be caused by various antipsychotics and how it can be treated. "
01/01/2006 - "Atypical antipsychotics may lead to agranulocytosis because of the apoptosis caused by cells binding nitrenium molecules. "
08/01/2002 - "Certain atypical antipsychotics are associated with a risk of metabolic changes as well as agranulocytosis. "

11/01/1993 - "The present study was undertaken to determine the efficacy of rhG-CSF administration in patients with methimazole-induced (MMI) agranulocytosis. "
01/01/2013 - "[Acute agranulocytosis from thiamazole: points for improvement in daily practice]."
06/01/2006 - "After initiation of treatment with 30 mg of thiamazole daily, the patient's thyroid function improved but 4 weeks later, thiamazole induced agranulocytosis occurred and the drug was discontinued. "
05/01/1991 - "Methimazole and agranulocytosis--clinical study."
01/01/2015 - "The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situation. "

02/01/1995 - "Agranulocytosis induced by macrolide antibiotics."
04/01/1994 - "Agranulocytosis has been reported in 5-15% of patients treated with high-dose betalactam antibiotics (BLA). "
12/01/1991 - "When Aspergillus is isolated in the setting of corticosteroid therapy, antibiotics, or granulocytopenia, one must suspect invasive disease."
04/01/1990 - "The patient with agranulocytosis was given corticosteroid, granulocyte concentrate, gammaglobulin, and antibiotics, too. "
06/01/1989 - "One patient died because of agranulocytosis secondary to treatment with antibiotics. "

01/01/2010 - "The patient demonstrated agranulocytosis caused by the administration of trimethoprim-sulfamethoxazole. "
09/08/2003 - "Trimethoprim-sulfamethoxazole-induced life-threatening agranulocytosis."
05/07/1988 - "[Cotrimoxazole-induced agranulocytosis]."
10/24/1987 - "[Cotrimoxazole-induced agranulocytosis]."
10/01/1984 - "Twenty patients were randomly assigned to treatment with trimethoprim/sulfamethoxazole during 20 episodes of profound granulocytopenia; 23 patients in the control group were followed through 25 granulocytopenic episodes. "

01/01/2012 - "We suggest that the presence of NA1 allele may be a predisposing factor to olanzapine-induced agranulocytosis in patients with SLE. "
01/01/2012 - "The relationship between agranulocytosis, SLE and olanzapine is still unknown. "
04/01/2011 - "Olanzapine-induced agranulocytosis in an adolescent male with psychosis."
01/30/2007 - "To our knowledge, no case of fatal agranulocytosis as a result of olanzapine treatment was reported in the literature. "
01/01/2007 - "We report a case of SLE who developed agranulocytosis during the treatment with olanzapine for the SLE-related psychiatric symptoms."

01/01/2006 - "The authors present their own observation of a patient suffering from drug-induced agranulocytosis, cured with filgastrim-neupogen, a recombinant colony-stimulating human granulocyte factor."
09/01/1994 - "Time from onset until resolution of agranulocytosis was 8.2 +/- 2.1 days compared with a historical study of seven cases where filgrastim was not used and 15.7 +/- 3.7 days were required for resolution. "
04/01/2004 - "Despite filgrastim, the major toxicities were hematologic with 15 of 30 patients developing grade 3/4 granulocytopenia. "
11/01/1998 - "Both were treated with filgrastim in an attempt to decrease the duration of agranulocytosis. "
11/01/1998 - "Administration of filgrastim in two patients with drug-induced agranulocytosis."

02/01/1988 - "The 24 patients who achieved a complete remission received one to nine (median, four) additional courses of intensive chemotherapy for remission consolidation and/or relapse, and experienced 132 episodes of severe granulocytopenia. "
09/01/1990 - "A total of 8 courses of anticancer chemotherapy with 25-30 mg/m2 of CDDP performed biweekly resulted in a partial remission (56%) but no side effects, including gastrointestinal damage and agranulocytosis. "
09/01/2005 - "During induction chemotherapy, grade 3/4 granulocytopenia occurred in 32% and 38% of patients on study arms 1 and 2, respectively. "
01/01/1993 - "Twenty-six patients who received two cycles of the identical chemotherapy regimen and had granulocytopenia less than 1 x 10(9) cells/l after the first cycle of chemotherapy were eligible for this study. "
11/01/2015 - "The chemotherapy-related toxicity of III/IV gastrointestinal reaction (RR = 0.54, 95% CI: 0.43-0.68) and III/IV granulocytopenia (RR = 0.65, 95% CI: 0.51-0.70) were significant decreased in the combined group. "

01/01/1982 - "This study suggests that leukocyte transfusions from unstimulated normal donors are effective in the management of patients with potentially reversible granulocytopenia."
08/20/1977 - "Leukocyte transfusions thus have an important adjuvant role in the management of patients with severe granulocytopenia."
01/01/1971 - "Histocompatible leukocyte transfusion during granulocytopenia."
04/23/1966 - "[The symptomatic treatment of agranulocytosis by leukocyte transfusion]."
08/20/1977 - "The role of leukocyte transfusions in the prevention and treatment of infections in adults with granulocytopenia was investigated. "

05/15/1991 - "Hospitalized adults without granulocytopenia who received a peripheral intravenous catheter. "
08/01/1988 - "Mean duration of catheter placement was 27 days, 17 of which were spent in granulocytopenia. "
12/01/1987 - "Primary necrotic chest wall lesions associated with Hickman catheters developed in four at a mean 11 days of granulocytopenia, followed by pulmonary involvement. "
03/01/1983 - "An improved technique for the insertion of Hickman catheters in patients with thrombocytopenia and granulocytopenia."
03/01/2014 - "Catheter-associated sepsis occurred in 2 of 3 patients with agranulocytosis. "

03/01/1949 - "A case of cyclical agranulocytosis with marked improvement following splenectomy."
05/01/1982 - "Granulocytopenia and monocytopenia were present; the latter was not often corrected by splenectomy. "
12/01/1951 - "Cyclic acute agranulocytosis: report of a case, with improvement after splenectomy."
01/01/1997 - "Effective splenectomy in agranulocytosis associated with systemic lupus erythematosus."
01/01/1996 - "Hence, the prognosis is unfavorable for patients with septic shock in a state of agranulocytosis, if their SAPS score on admission is higher than 21, if they develop polyorgan failure with involvement of more than three organ systems, have a history of splenectomy, their hemoblastosis is resistant to chemotherapy, and there are no prospects for granulocytopoiesis recovery."

10/01/1982 - "However, the agranulocytosis improved with repeated plasmapheresis and the patient achieved a clinical remission."
07/01/1996 - "[Intensive care of myelotoxic agranulocytosis using nonselective plasmapheresis]."
07/01/1995 - "Plasmapheresis was applied in 10 patients given chemotherapy and radiation treatment for myelotoxic agranulocytosis. "
01/01/2011 - "Successful preoperative treatment of a Graves' disease patient with agranulocytosis and hemophagocytosis using double filtration plasmapheresis."
01/01/2004 - "Plasmapheresis in the treatment of hyperthyroidism associated with agranulocytosis: A case report."