Agmatine

01/01/2023 - "While additional mechanistic studies into agmatine are necessary, these findings support the broad-based efficacy of agmatine to treat co-morbid excessive drinking and pain symptoms in the context of AUD."
07/23/2007 - "The present study examined the anti-hypernociceptive effects of agmatine (AGM) in acute and chronic models of behavioural pain in mice. "
06/01/2005 - "The present study examined the antinociceptive effects of agmatine in chemical behavioural models of pain. "
12/01/2003 - "The present study was designed to investigate effect of agmatine on acute and mononeuropathic pain after chronic constriction injury (CCI). "
07/23/2007 - "Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice."

05/14/2012 - "To investigate the effect of administration of agmatine (AGM) on gastric protection against ischemia reperfusion (I/R) injury. "
09/01/2010 - "Global ischemia led severe neuronal damage in the rat hippocampus and cerebral cortex, but agmatine treatment protected neurons from ischemic injury. "
09/01/2010 - "Global ischemia was induced with four vessel occlusion (4-VO) and agmatine (100 mg/kg) was administered intraperitoneally at the onset of reperfusion. "
03/01/2008 - "Protective effect of agmatine on ischemia/reperfusion-induced renal injury in rats."
04/01/2006 - "One-hour temporary occlusion of the left middle cerebral artery of cats was performed in the control ischemia group (n = 10), and 100 mg/kg of agmatine was intravenously injected immediately after recanalization in the agmatine-treated group (n = 15). "

02/23/2020 - "Previous clinical studies strongly support the use of dietary agmatine as a safe and effective treatment for neuropathic pain. "
01/01/2021 - "The present study interrogated the dependence of agmatine's alleviation of neuropathic pain (spared nerve injury (SNI) model) on GluN2B-containing NMDArs. "
08/15/2013 - "These results suggest that both the σ₁ and σ₂ receptor subunits within hippocampus play an important role in antinociceptive action of agmatine against neuropathic pain."
08/15/2013 - "Intrahippocampal (i.h.) as well as intraperitoneal (i.p.) administration of agmatine attenuated neuropathic pain in sciatic nerve ligated rats. "
12/01/2003 - "Among several biologic effects, the ability of agmatine to protect against ischemic injury and chronic neuropathic pain is particularly interesting. "

10/01/2008 - "There were no significant differences between the groups at 1 day or 3 days after trauma, but evaluation after 8 days revealed a significant improvement in the group treated with agmatine. "
02/01/2015 - "To observe protective effects of agmatine (AGM) on inflammatory response and spleen immune function in mice with trauma. "
07/24/2009 - "Finally, our studies revealed that agmatine can rescue astrocytes from death caused by ischemic and/or ischemic-perfusion neuronal injuries in vitro. "
01/01/2019 - "The review is focused on the role of agmatine in different types and mechanisms of neural injuries. "
02/01/2015 - "[Effects of agmatine on excessive inflammatory reaction and proliferation of splenic cells in mice with trauma]."

01/01/2020 - "Agmatine ameliorates manifestation of depression-like behavior and hippocampal neuroinflammation in mouse model of Alzheimer's disease."
01/01/2021 - "The present study sought to assess alterations in agmatine metabolism in the beta-amyloid (Aβ1-42) Alzheimer's disease mouse model. "
01/01/2017 - "Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling."
01/01/2018 - "Numerous studies had demonstrated the neuroprotective effect of agmatine in varied types of neurological diseases, including acute attack (stroke and trauma brain injury) and chronic neurodegenerative diseases (Parkinson's disease, Alzheimer's disease). "
01/01/2014 - "Consistent with its neuromodulatory and neuroprotective properties, there is increasing number of preclinical studies demonstrating the beneficial effects of exogenous agmatine administration on depression, anxiety, hypoxic ischemia, nociception, morphine tolerance, memory, Parkinson`s disease, Alzheimer`s disease, traumatic brain injury related alterations/disorders and epilepsy. "