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Psychotic Affective Disorders

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Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.

Also Known As:

Affective Disorders, Psychotic; Psychotic Mood Disorders; Affective Disorder, Psychotic; Affective Psychoses; Disorder, Psychotic Affective; Disorders, Psychotic Affective; Mood Disorder, Psychotic; Psychotic Affective Disorder; Psychotic Mood Disorder; Depression, Reactive, Psychotic; Mood Disorders, Psychotic; Psychoses, Affective

Networked: 150 relevant articles (9 outcomes, 20 trials/studies)

Relationship Network

Disease Context: Research Results

Mental Disorders: 2989
- Mood Disorders: 6344
  - Psychotic Affective Disorders: 150
    - Bipolar Disorder: 9428

Related Diseases

1.	Psychotic Disorders (Schizoaffective Disorder)
2.	Schizophrenia (Dementia Praecox)
3.	Bipolar Disorder (Mania)
4.	Atrophy
5.	Mood Disorders (Mood Disorder)

Experts

1.	Murray, Robin M: 3 articles (10/2012 - 01/2009)
2.	Castro-Fornieles, Josefina: 2 articles (12/2015 - 06/2014)
3.	Baeza, Inmaculada: 2 articles (12/2015 - 06/2014)
4.	Arango, Celso: 2 articles (12/2015 - 06/2014)
5.	Graell, Montserrat: 2 articles (12/2015 - 06/2014)
6.	Payá, Beatriz: 2 articles (12/2015 - 06/2014)
7.	Parellada, Mara: 2 articles (12/2015 - 06/2014)
8.	González-Pinto, Ana: 2 articles (12/2015 - 06/2014)
9.	Mellor, Andrew: 2 articles (03/2015 - 07/2013)
10.	Miller, Brian J: 2 articles (03/2015 - 07/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Psychotic Affective Disorders:

1.	Clozapine (Clozaril)FDA LinkGeneric 09/01/1995 - "A growing literature suggests that the atypical antipsychotic agent clozapine may be effective in schizoaffective and psychotic mood disorders. " 10/01/1991 - "The purpose of this study was to assess whether or not clozapine is effective in some patients with schizoaffective disorder or psychotic mood disorders. " 01/01/1997 - "Evidence indicates that clozapine is effective in the management of treatment-resistant schizophrenia and in affective psychoses. " 10/01/1991 - "Clozapine may be a useful drug in the treatment of patients with schizoaffective disorder or psychotic mood disorders who are treatment resistant or intolerant of side effects." 09/01/1995 - "Clozapine appears to be effective and well-tolerated in the short-term and maintenance treatment of severe or psychotic mood disorders, particularly in the manic-excited phases of schizoaffective and bipolar disorders, even in patients who have not responded well to conventional pharmacotherapies."
2.	Antipsychotic Agents (Antipsychotics)IBA 06/01/2002 - "There was no evidence that treatment with neuroleptics influenced the fertility rate in women with non-affective psychoses. " 09/01/2001 - "Atypical antipsychotics, which appear to possess thymoleptic properties, may represent a new treatment alternative for patients with psychotic mood disorders. " 01/01/2000 - "Atypical antipsychotics appear to have a number of advantages over typical agents in the treatment of patients with psychotic mood disorders." 12/01/1988 - "We propose that some patients with affective psychoses are uniquely susceptible to profound blockade of the nigrostriatal dopaminergic system by neuroleptics." 06/01/2009 - "One-third of patients under age 18 who are prescribed second-generation antipsychotics use them for the treatment of affective psychoses, primarily bipolar disorder (34%). "
3.	LithiumIBA 12/01/1993 - "The risk of lithium treatment against other risks to peripheral nervous system in psychiatric patients with affective psychoses was tested in our study. " 01/01/1983 - "For example, recent research on the success of lithium treatment in schizo-affective psychoses shows the practical relevance of this line of study. " 01/01/1981 - "[Clinico-psychological study of organic psychosyndromes associated with affective psychoses with and without lithium therapy]." 01/01/1980 - "[Pharmacokinetic study of delayed-action lithium in affective psychoses]." 01/01/1977 - "[Possible prediction of the preventive use of lithium in affective psychoses based on a study of the erythrocyte index]."
4.	olanzapine (Zyprexa)FDA Link 01/01/1998 - "However, little is known about the efficacy of olanzapine in patients with psychotic mood disorders. " 07/01/2001 - "The purpose of this naturalistic study was to determine the long-term effectiveness and tolerability of olanzapine as add-on therapy in psychotic mood disorders. " 07/01/2001 - "Recent studies suggest a role for the atypical antipsychotic olanzapine in the acute treatment of psychotic mood disorders, but long-term data are unavailable. " 07/01/2001 - "However, only 26% of the patients with psychotic mood disorders sustained a clinically meaningful mood-stabilizing effect with add-on olanzapine treatment at follow-up." 07/01/2001 - "Mood symptoms predicted a better response to add-on olanzapine in patients with psychotic mood disorders on selective outcome measures. "
5.	Hydrocortisone (Cortisol)FDA LinkGeneric 10/01/1987 - "The sensitivity of the DST (rate of a positive outcome, or nonsuppression of cortisol) in major depression is modest (about 40%-50%) but is higher (about 60%-70%) in very severe, especially psychotic, affective disorders, including major depression with psychotic as well as melancholic features, mania, and schizoaffective disorder. " 10/01/1989 - "Plasma cortisol was increased to a lesser extent in other psychotic subgroups, and increases in prolactin were most marked in the affective psychoses. " 04/01/1990 - "In this study we have measured the concentrations of dopamine, noradrenaline, adrenaline, 5-HT, TSH, prolactin, HGH, melatonin, cortisol, T 3, T 4 and 28 amino acids in blood samples (examined 8 times within 24 hours) from 48 schizophrenic patients, divided in 4 subgroups (each 12 cases) with severe, moderate, slight or lacking process-activity, from 20 patients with (inactive or only slight active) depressive phases of affective psychoses and from normal controls. "
6.	quetiapine (Seroquel)FDA Link 03/01/2000 - "However, little is known about the efficacy of quetiapine in patients with psychotic mood disorders. " 03/01/2000 - "Clinical predictors of acute response with quetiapine in psychotic mood disorders." 03/01/2000 - "The purpose of this study was to assess the efficacy of quetiapine in the treatment of psychotic mood disorders in comparison with nonaffective psychotic disorders and identify clinical factors associated with quetiapine response. " 10/01/2014 - "The top 4 diagnoses associated with quetiapine in 2012 were mood disorders, psychotic disorders, anxiety disorders and sleep disturbances. "
7.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/1989 - "The results of dexamethasone test (DT) in patients with affective psychoses are presented. " 01/01/1989 - "[Dexamethasone test in the diagnosis and treatment of affective psychoses]." 10/01/1991 - "Schizophrenia and affective psychoses share the following: 1) several treatments are effective in both, 2) similar modes of inheritance, 3) congruent seasonal birth excesses, 4) enlarged cerebral ventricles and cerebellar vermian atrophy, 5) dexamethasone non-suppression. " 01/01/1990 - "As many as 30 patients with affective psychoses were examined for the concentration of plasma kynurenine, a neuroactive tryptophan metabolite, and for the parameters of the dexamethasone test. "
8.	Risperidone (Risperdal Consta)FDA LinkGeneric 06/01/1996 - "Risperidone, a 5-HT2 and D2 antagonist, has been shown to be an effective antipsychotic in the treatment of schizophrenia but has unclear efficacy in the treatment of psychotic affective disorders. " 10/01/1995 - "Clinical predictors of acute risperidone response in schizophrenia, schizoaffective disorder, and psychotic mood disorders." 10/01/1995 - "However, little is known about the efficacy of risperidone in patients with schizophrenia refractory to treatment with typical antipsychotics, schizoaffective disorder, and psychotic mood disorders. "
9.	Pentylenetetrazole (Metrazol)IBA 10/01/1991 - "Virtually all antidepressant and antipsychotic drugs, including clozapine, rimcazole and lithium ion, are proconvulsants, and convulsive therapy, using metrazol, a known GABA-A antagonist, as well as electro-convulsive therapy, can be effective in treating both schizophrenia and affective psychoses. "
10.	gamma-Aminobutyric Acid (GABA)IBA 10/01/1991 - "Virtually all antidepressant and antipsychotic drugs, including clozapine, rimcazole and lithium ion, are proconvulsants, and convulsive therapy, using metrazol, a known GABA-A antagonist, as well as electro-convulsive therapy, can be effective in treating both schizophrenia and affective psychoses. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/2011 - "The main indications for the electroconvulsive therapy (ECT) - psychotropic drug combination are pharmacotherapy-resistant, severe schizophrenic or affective psychoses. " 01/01/2001 - "The authors report 5 patients with psychotic mood disorders and long-standing antipsychotic drug therapy. " 01/01/1994 - "The treatment of psychotic mood disorders, regardless of coexisting conditions, requires pharmacotherapy--usually a combination of an antipsychotic drug and a medication for mood--or electroconvulsive therapy. " 09/01/1995 - "Clozapine appears to be effective and well-tolerated in the short-term and maintenance treatment of severe or psychotic mood disorders, particularly in the manic-excited phases of schizoaffective and bipolar disorders, even in patients who have not responded well to conventional pharmacotherapies."
2.	Ambulatory Care (Outpatient Care) 01/01/2014 - "The purpose of this study was to estimate the 1-year prevalence of schizophrenia (ICD-10 F20) and non-affective psychoses (ICD-10 F20-F29) in Stockholm County using population-based health records from inpatient and outpatient care. "
3.	Aftercare (After-Treatment) 09/01/1999 - "This UK-based study compares the pathways to the psychiatric hospital and the provision of in-patient and after-care for Asian, black and white patients with non-affective psychoses. " 09/01/1999 - "Mental health care for Asian, black and white patients with non-affective psychoses: pathways to the psychiatric hospital, in-patient and after-care."
4.	Transplants (Transplant) 12/01/1976 - "Affective psychoses following renal transplant."
5.	Kidney Transplantation 12/01/1976 - "Six patients who developed affective psychoses following renal transplantation ae reported. "