Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

Also Known As:

beta-Adrenergic Blocking Agents; beta-Adrenergic Antagonists; beta-Adrenergic Blockers; beta-Adrenoceptor Antagonists; Adrenergic beta Antagonist; Adrenergic beta Antagonists; Adrenergic beta Receptor Blockader; Adrenergic beta Receptor Blockaders; Adrenergic beta-Blockers; Agent, beta-Adrenergic Blocking; Agents, beta-Adrenergic Blocking; Antagonist, beta-Adrenergic; Antagonist, beta-Adrenoceptor; Antagonists, beta-Adrenergic; Antagonists, beta-Adrenoceptor; Blockader, Adrenergic beta-Receptor; Blockader, beta-Adrenergic Receptor; Blockaders, Adrenergic beta-Receptor; Blockaders, beta-Adrenergic Receptor; Blocker, beta-Adrenergic; Blockers, beta-Adrenergic; Blocking Agent, beta-Adrenergic; Blocking Agents, beta-Adrenergic; Receptor Blockader, beta-Adrenergic; Receptor Blockaders, beta-Adrenergic; beta Adrenergic Antagonist; beta Adrenergic Antagonists; beta Adrenergic Blocker; beta Adrenergic Blockers; beta Adrenergic Blocking Agent; beta Adrenergic Blocking Agents; beta Adrenergic Receptor Blockader; beta Adrenergic Receptor Blockaders; beta Adrenoceptor Antagonist; beta Adrenoceptor Antagonists; beta Blockers, Adrenergic; beta-Antagonist, Adrenergic; beta-Antagonists, Adrenergic; beta-Receptor Blockader, Adrenergic; beta-Receptor Blockaders, Adrenergic; Adrenergic beta-Antagonist; Adrenergic beta-Receptor Blockader; Adrenergic beta-Receptor Blockaders; beta-Adrenergic Antagonist; beta-Adrenergic Blocker; beta-Adrenergic Blocking Agent; beta-Adrenergic Receptor Blockader; beta-Adrenergic Receptor Blockaders; beta-Adrenoceptor Antagonist; beta-Blockers, Adrenergic

Networked: 1838 relevant articles (154 outcomes, 214 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Neurotransmitter Agents: 13181
      - Adrenergic Agents: 9549
        Adrenergic Antagonists: 736
        Adrenergic beta-Antagonists: 1838
        Adrenergic beta-1 Receptor Antagonists: 2
        Adrenergic beta-2 Receptor Antagonists
        Adrenergic beta-3 Receptor Antagonists
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13181
      - Adrenergic Agents: 9549
        Adrenergic Antagonists: 736
        Adrenergic beta-Antagonists: 1838
        Adrenergic beta-1 Receptor Antagonists: 2
        Adrenergic beta-2 Receptor Antagonists
        Adrenergic beta-3 Receptor Antagonists

Experts

1.	Frishman, William H: 5 articles (01/2020 - 01/2002)
2.	Isseroff, R Rivkah: 4 articles (01/2022 - 01/2009)
3.	Esler, Murray: 4 articles (05/2012 - 07/2003)
4.	Oberbeck, Reiner: 4 articles (01/2009 - 10/2002)
5.	Gallegos, Anthony: 3 articles (01/2022 - 06/2020)
6.	Grimm, Daniela: 3 articles (09/2019 - 05/2012)
7.	Wehland, Markus: 3 articles (09/2019 - 05/2012)
8.	Pitman, Roger K: 3 articles (07/2014 - 01/2002)
9.	Simonsen, Ulf: 3 articles (05/2012 - 08/2004)
10.	Ben-Eliyahu, Shamgar: 3 articles (03/2010 - 11/2003)

Related Diseases

1.	Heart Failure 12/01/2000 - "Large-scale trials have shown that a marked decrease in mortality can be obtained by treatment of chronic heart failure with beta-adrenergic blocking agents. " 03/07/2003 - "Recent clinical studies in humans also support the idea that beneficial heart failure treatments, such as beta-adrenergic antagonists, involve improved contractility. " 07/01/1998 - "In a large number of randomized, double-blind, placebo-controlled trials, long-term treatment of patients with chronic heart failure with beta-adrenergic blockers improves cardiac function, ameliorates symptoms, and reduces the risk of death and hospitalization. " 08/01/2008 - "Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure." 01/01/2004 - "The addition of beta-adrenergic antagonists to the treatment regimen for heart failure has validated the neurohormonal hypothesis and provided much-improved outcomes. "
2.	Hypertension (High Blood Pressure) 11/10/1983 - "Beta-adrenoceptor antagonists are effective in the management of patients with mild-to-moderate hypertension. " 01/01/2007 - "beta-Adrenoceptor antagonists (beta-blockers) have historically been considered an effective and safe option for first-line treatment of hypertension. " 12/01/2020 - "Clinicians should be cautious when prescribing beta-adrenergic blocker in patients with hypertension and upper quadrant mass of unknown etiology. " 01/01/2019 - "After adequate control of the hypertension was achieved with nonselectivealpha- and beta-adrenergic blockers the tumour was excised. " 12/01/2009 - "Beta-adrenergic antagonists in hypertension: a review of the evidence."
3.	Myocardial Infarction 05/01/1995 - "Our aim was to determine the percent of patients with myocardial infarction who are treated with beta-adrenergic blocking agents in dosages proved to be effective in preventing death after a heart attack. " 11/01/1989 - "Previously reported data document that efficacy of beta-adrenergic antagonists in lowering mortality rates after acute myocardial infarction. " 12/01/2003 - "Dosages of beta-adrenergic blockers prescribed after myocardial infarction (MI) in a Veterans Affairs medical center were reviewed to determine if dosages were adjusted to target dosages used in clinical trials. " 03/01/1998 - "This study was designed to assess the long-term effects of a beta1-selective beta-adrenergic blocking agent on mortality, in vivo hemodynamic function, left ventricular volume and wall stress in post-myocardial infarction (MI) rats. " 05/01/1995 - "Treatment with beta-adrenergic blocking agents after myocardial infarction: from randomized trials to clinical practice."
4.	Angina Pectoris 01/01/1985 - "Beta adrenoceptor antagonists are effective in the symptomatic management of angina pectoris. " 03/01/1978 - "Clinical trials with beta-adrenergic blocking agents in angina pectoris." 01/01/1972 - "[Study of the action of beta-adrenergic blockers in the treatment of angina pectoris]." 05/01/1997 - "Although their long-term effects on the mortality of angina pectoris have not been fully investigated, investigations indicate that, compared with other drugs, beta-adrenergic blocking agents significantly decrease the frequency and duration of angina pectoris. " 01/01/1991 - "[Lipid peroxidation in patients with unstable stenocardia treated with adrenergic beta blockers]."
5.	Hemorrhage 07/01/1990 - "The use of beta-adrenergic blockers offers the most promise for prevention of initial variceal bleeding." 11/01/2007 - "Nonselective beta-adrenergic blockers decrease portal pressure and are effective in preventing variceal hemorrhage. " 11/24/2005 - "Nonselective beta-adrenergic blockers decrease portal pressure and prevent variceal hemorrhage. " 10/01/2002 - "Influence of beta-adrenoceptor antagonists on hemorrhage-induced cellular immune suppression." 02/01/1997 - "These results show that beta-adrenoceptor antagonists must be used to prevent the first episode of GI bleeding. "

Related Drugs and Biologics

1.	Propranolol (Inderal)
2.	Diuretics
3.	Antihypertensive Agents (Antihypertensives)
4.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
5.	Calcium
6.	Metoprolol (Toprol-XL)
7.	Calcium Channel Blockers (Blockers, Calcium Channel)
8.	Angiotensin Receptor Antagonists
9.	Sotalol (Sotalol Hydrochloride)
10.	Betaxolol (Kerlon)

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4.	Sclerotherapy
5.	Secondary Prevention