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Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)

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Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

Also Known As:

beta-Adrenergic Blocking Agents; beta-Adrenergic Blockers; Adrenergic beta Antagonists; Adrenergic beta Receptor Blockaders; Adrenergic beta-Blockers; Agents, beta-Adrenergic Blocking; Blockaders, Adrenergic beta-Receptor; Blockaders, beta-Adrenergic Receptor; Blockers, beta-Adrenergic; Blocking Agents, beta-Adrenergic; Receptor Blockaders, beta-Adrenergic; beta Adrenergic Blockers; beta Adrenergic Blocking Agents; beta Adrenergic Receptor Blockaders; beta Blockers, Adrenergic; beta-Antagonists, Adrenergic; beta-Receptor Blockaders, Adrenergic; Adrenergic beta-Receptor Blockaders; beta-Adrenergic Receptor Blockaders; beta-Blockers, Adrenergic

Networked: 622 relevant articles (59 outcomes, 63 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Molecular Mechanisms of Pharmacological Action: 7
    - Neurotransmitter Agents: 7915
      - Adrenergic Agents: 322
        Adrenergic Antagonists: 1042
        Adrenergic beta-Antagonists: 622
        Adrenergic beta-1 Receptor Antagonists
        Adrenergic beta-2 Receptor Antagonists
        Adrenergic beta-3 Receptor Antagonists
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 7915
      - Adrenergic Agents: 322
        Adrenergic Antagonists: 1042
        Adrenergic beta-Antagonists: 622
        Adrenergic beta-1 Receptor Antagonists
        Adrenergic beta-2 Receptor Antagonists
        Adrenergic beta-3 Receptor Antagonists

Experts

1.	Frishman, William H: 3 articles (12/2007 - 01/2002)
2.	Lamm, Gudrun: 3 articles (09/2007 - 09/2005)
3.	Eber, Bernd: 3 articles (09/2007 - 09/2005)
4.	Weber, Thomas: 3 articles (09/2007 - 09/2005)
5.	Berent, Robert: 3 articles (09/2007 - 09/2005)
6.	Auer, Johann: 3 articles (09/2007 - 09/2005)
7.	Hersh, Elliot V: 2 articles (06/2015 - 10/2010)
8.	Esler, Murray: 2 articles (05/2012 - 02/2010)
9.	Deedwania, Prakash C: 2 articles (03/2010 - 11/2009)
10.	Marine, Joseph E: 2 articles (03/2009 - 04/2004)

Related Diseases

1.	Heart Failure 12/01/2000 - "Large-scale trials have shown that a marked decrease in mortality can be obtained by treatment of chronic heart failure with beta-adrenergic blocking agents. " 07/01/1998 - "In a large number of randomized, double-blind, placebo-controlled trials, long-term treatment of patients with chronic heart failure with beta-adrenergic blockers improves cardiac function, ameliorates symptoms, and reduces the risk of death and hospitalization. " 05/07/2001 - "Current role of beta-adrenergic blockers in the management of chronic heart failure." 11/01/2000 - "Chronic treatment with beta-adrenergic blocking agents has been shown to improve left ventricular (LV) ejection fraction and attenuate progressive LV remodeling in heart failure (HF). " 05/01/1997 - "Beta-adrenergic blocking agents have shown to improve functional class and the ventricular function of heart failure patients; the use of these agents should be considered in congestive heart failure patients unless an increase in mortality with betablockers can be demonstrated. "
2.	Hypertension (High Blood Pressure) 03/01/2010 - "Beta adrenergic blockers have had a long history as frontline agents in hypertension therapy. " 06/01/2007 - "[Current position of beta-adrenergic blockers in the management of arterial hypertension]." 02/01/2007 - "Is there a role for beta-adrenergic blockers in treating hypertension in children?" 01/01/2002 - "[Treatment arterial hypertension by beta-adrenergic blockers in elderly patients with gastrointestinal disorders]." 01/01/2002 - "Beta-adrenergic blockers in systemic hypertension: pharmacokinetic considerations related to the current guidelines."
3.	Hemorrhage 07/01/1990 - "The use of beta-adrenergic blockers offers the most promise for prevention of initial variceal bleeding." 11/01/2007 - "Nonselective beta-adrenergic blockers decrease portal pressure and are effective in preventing variceal hemorrhage. " 11/24/2005 - "Nonselective beta-adrenergic blockers decrease portal pressure and prevent variceal hemorrhage. " 07/01/1997 - "Nonselective beta-adrenergic blockers are the only proven therapy for prevention of first variceal hemorrhage. " 06/01/1992 - "The use of nonselective beta adrenergic blockers according to previous data, descreases portal vein pressure and mostly prevents the initial bleeding. "
4.	Myocardial Infarction 05/01/1995 - "Our aim was to determine the percent of patients with myocardial infarction who are treated with beta-adrenergic blocking agents in dosages proved to be effective in preventing death after a heart attack. " 12/01/2003 - "Dosages of beta-adrenergic blockers prescribed after myocardial infarction (MI) in a Veterans Affairs medical center were reviewed to determine if dosages were adjusted to target dosages used in clinical trials. " 05/01/1995 - "Treatment with beta-adrenergic blocking agents after myocardial infarction: from randomized trials to clinical practice." 12/01/1985 - "Long-term clinical trials have been carried out to evaluate the effectiveness of beta-adrenergic blocking agents in modifying the natural history of myocardial infarction (MI). " 08/01/2007 - "To evaluate the effects of patient copayment and coinsurance policies on adherence to therapy with beta-adrenergic blocking agents (beta-blockers) and on the rate of initiation of beta-blocker therapy after acute myocardial infarction (MI) in a population-based natural experiment. "
5.	Angina Pectoris 01/01/1972 - "[Study of the action of beta-adrenergic blockers in the treatment of angina pectoris]." 05/01/1997 - "Although their long-term effects on the mortality of angina pectoris have not been fully investigated, investigations indicate that, compared with other drugs, beta-adrenergic blocking agents significantly decrease the frequency and duration of angina pectoris. " 03/07/1995 - "The pharmacological properties of beta-adrenergic blockers are summarized with regard to the therapy of stable angina pectoris. " 01/01/1991 - "[Lipid peroxidation in patients with unstable stenocardia treated with adrenergic beta blockers]." 05/15/1987 - "In approximately 2 decades, the role of these agents in the patient with angina pectoris has expanded from one primarily involving the adjunctive treatment of the patient refractory to other drugs, to the present, in which beta-adrenergic blockers are the most common prophylactic agent prescribed for this indication."

Related Drugs and Biologics

1.	Diuretics
2.	Propranolol (Inderal)
3.	Calcium
4.	Nitrates
5.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
6.	Calcium Channel Blockers (Blockers, Calcium Channel)
7.	Metoprolol (Lopressor)
8.	Isoproterenol (Isoprenaline)
9.	Aspirin (Acetylsalicylic Acid)
10.	Angiotensins

Related Therapies and Procedures

1.	Ligation
2.	Sclerotherapy
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4.	Transcutaneous Electric Nerve Stimulation (TENS)
5.	Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)