Adrenal Rest Tumor

Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.

Also Known As:

Networked: 31 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Virilism (Virilization)
2.	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
3.	Azoospermia
4.	Infertility (Sterility)
5.	Adenoma (Adenomas)

Experts

1.	Otten, Barto J: 3 articles (09/2007 - 04/2003)
2.	Hermus, Ad R M M: 3 articles (09/2007 - 04/2003)
3.	Quinkler, Marcus: 2 articles (01/2014 - 05/2010)
4.	Schwarz, Hans-Peter: 2 articles (11/2013 - 05/2010)
5.	Beuschlein, Felix: 2 articles (11/2013 - 05/2010)
6.	Reisch, Nicole: 2 articles (11/2013 - 05/2010)
7.	Reincke, Martin: 2 articles (11/2013 - 05/2010)
8.	Sasano, Hironobu: 2 articles (06/2011 - 01/2008)
9.	Sweep, Fred C G J: 2 articles (09/2007 - 09/2007)
10.	Claahsen-van der Grinten, Hedi L: 2 articles (09/2007 - 09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adrenal Rest Tumor:

1.	EnzymesIBA 01/01/2008 - "A case of adrenal rest tumor of the liver: Radiological imaging and immunohistochemical study of steroidogenic enzymes." 07/01/1997 - "Adrenal rest tumor of the broad ligament: case report with immunohistochemical study of steroidogenic enzymes." 09/01/2007 - "Testicular adrenal rest tumors produce adrenal-specific steroids and express adrenal-specific enzymes and ACTH and AII receptors, confirming the strong resemblance with adrenal tissue. " 01/01/1985 - "Ketoconazole, an imidazole derivative known to inhibit cytochrome P450-dependent adrenal enzymes was given to a patient with a functioning adrenal rest tumor of the liver in preparation for surgery. "
2.	Adrenocorticotropic Hormone (ACTH)FDA Link 03/01/2012 - "This study confirms the high prevalence of testicular adrenal rest tumors in patients with CAH and the major role played in its pathogenesis by high plasma ACTH levels." 03/01/2012 - "The aim of this work was to (1) evaluate the prevalence of testicular adrenal rest tumors in patients with CAH; (2) study the hormonal profile; (3) define the sonographic features; (4) assess the seminal profile; and (5) initiate a longitudinal study on the possible role of corticotropin (ACTH) plasma levels in the induction and persistence of testicular adrenal rest tumors. " 01/01/2013 - "Testicular adrenal rest tumors (TARTs) are an important complication of CAH, which probably develop from ectopic remnants of intra-testicular adrenal tissue stimulated by Adrenocorticotropic hormone (ACTH) hypersecretion. " 04/01/2014 - "Testicular adrenal rest tumors (TART) occur often as asymptomatic nodules in corticotropin-dependent lesions aberrant adrenal tissue in congenital adrenal hyperplasia (CAH) patients. " 01/01/2012 - "Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). "
3.	HormonesIBA 11/01/1957 - "Ovarian adrenal rest tumor (masculinovoblastoma) simulating adrenal virilism; report of a case with hormone studies."
4.	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 11/01/2014 - "131I-noriodocholesterol uptake by testicular adrenal rest tumors in a patient with classical 21-hydroxylase deficiency." 05/01/2010 - "Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency." 01/01/2014 - "Men with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency show impaired fecundity due to testicular adrenal rest tumors and/or suppression of the gonadal axis. " 11/01/2013 - "Testicular adrenal rest tumors develop independently of long-term disease control: a longitudinal analysis of 50 adult men with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency." 01/01/2011 - "The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency."
5.	SteroidsIBA 06/01/2015 - "C21 steroids in the peripheral sera from all subjects, as well as in media from cultured testicular adrenal rest tumor (TART) cells and normal adrenal (NA) cells, were analyzed using liquid chromatography/tandem mass spectrometry (10 steroids). " 06/01/2011 - "Malignant adrenal rest tumor of the retroperitoneum producing adrenocortical steroids." 09/01/2007 - "Testicular adrenal rest tumors produce adrenal-specific steroids and express adrenal-specific enzymes and ACTH and AII receptors, confirming the strong resemblance with adrenal tissue. "
6.	ProgesteroneFDA LinkGeneric 12/01/2015 - "In addition, elevated serum progesterone concentrations may hinder ovulation and embryo implantation in women, whereas in men testicular adrenal rest tumors can be a major cause of infertility. " 04/01/2003 - "Several factors have been suggested to contribute to the impaired fertility in CAH females: adrenal overproduction of androgens and progestins (17-hydroxyprogesterone and progesterone), ovarian hyperandrogenism, polycystic ovary syndrome, ovarian adrenal rest tumors, neuroendocrine factors, genital surgery, and psychological factors such as delayed psychosexual development, reduced sexual activity and low maternal feelings. "
7.	GlucocorticoidsIBA 11/07/2010 - "Authors present the history of a young adult male with 11β-hydroxylase deficiency who developed adrenal rest tumors presenting as palpable bilateral testicular masses during treatment with glucocorticoids, then testicular masses showed a rapid regression after an adequate glucocorticoid treatment. " 01/01/2005 - "In males, the main cause of subfertiltiy is the presence of testicular adrenal rest tumors, which are thought to originate from aberrant adrenal tissue and respond to treatment with glucocorticoids. "
8.	17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)IBA 04/01/2003 - "Several factors have been suggested to contribute to the impaired fertility in CAH females: adrenal overproduction of androgens and progestins (17-hydroxyprogesterone and progesterone), ovarian hyperandrogenism, polycystic ovary syndrome, ovarian adrenal rest tumors, neuroendocrine factors, genital surgery, and psychological factors such as delayed psychosexual development, reduced sexual activity and low maternal feelings. "
9.	Testosterone (Sustanon)FDA Link 04/01/2014 - "In hypogonadotropic, azoospermic CAH, a combined treatment with oral corticosteroids and subcutaneously administered hCG and FSH can successfully restore testicular testosterone production and fertility, even if only one hypoplastic and atrophic testis with adrenal rest tumors is present."
10.	Progestins (Progestagens)IBA 04/01/2003 - "Several factors have been suggested to contribute to the impaired fertility in CAH females: adrenal overproduction of androgens and progestins (17-hydroxyprogesterone and progesterone), ovarian hyperandrogenism, polycystic ovary syndrome, ovarian adrenal rest tumors, neuroendocrine factors, genital surgery, and psychological factors such as delayed psychosexual development, reduced sexual activity and low maternal feelings. "

Therapies and Procedures

1.	Adrenalectomy 04/01/2014 - "Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy." 01/01/2010 - "Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy."