Adrenal Gland Neoplasms (Adrenal Cancer)

Tumors or cancer of the ADRENAL GLANDS.

Also Known As:

Adrenal Cancer; Adrenal Gland Cancer; Adrenal Neoplasm; Cancer of the Adrenal Gland; Neoplasms, Adrenal Gland; Adrenal Cancers; Adrenal Gland Cancers; Adrenal Gland Neoplasm; Adrenal Neoplasms; Cancer, Adrenal; Cancer, Adrenal Gland; Cancers, Adrenal; Cancers, Adrenal Gland; Neoplasm, Adrenal; Neoplasm, Adrenal Gland; Neoplasms, Adrenal

Networked: 243 relevant articles (14 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Adenoma (Adenomas)
3.	Adrenocortical Carcinoma
4.	Neoplasm Metastasis (Metastasis)
5.	Pheochromocytoma

Experts

1.	Koo, Ja Seung: 3 articles (08/2023 - 01/2021)
2.	Auchus, Richard J: 3 articles (01/2023 - 05/2013)
3.	Mayo-Smith, William W: 3 articles (01/2023 - 04/2004)
4.	Bertherat, Jérôme: 3 articles (01/2018 - 08/2003)
5.	Kebebew, Electron: 3 articles (09/2017 - 08/2002)
6.	Schteingart, David E: 3 articles (07/2012 - 06/2007)
7.	Grossman, Ashley B: 2 articles (01/2024 - 05/2011)
8.	Kim, Eun Kyung: 2 articles (07/2023 - 01/2021)
9.	Brook, Olga R: 2 articles (01/2023 - 01/2011)
10.	Elsayes, Khaled M: 2 articles (01/2023 - 03/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adrenal Gland Neoplasms:

1.	Fas Ligand Protein (Fas Ligand)IBA 03/01/2005 - "Additional studies on MHC class II genotype and phenotype and the altered Fas/Fas ligand system in adrenal neoplasms may help to identify mechanisms of immune escape and suggest new diagnostic approaches." 03/01/2005 - "Therefore, MHC class II phenotype and genotype and expression patterns of the Fas/Fas ligand system were investigated in 24 adrenocortical tumors (n(Adenomas) = 14, n(Carcinomas) = 10) and an adrenal cancer cell line (NCI-H295). "
2.	Apolipoproteins E (ApoE)IBA 09/01/1994 - "The results indicate that apo E may relate to the functional activity of adrenal cortex, and suggest that immunohistochemical study for apo E may help to distinguish the malignancy from benign adrenal neoplasms."
3.	Phosphotransferases (Kinase)IBA 01/01/2018 - "Together these data suggest that MELK is a modulator of tumor cell growth and survival in a hypoxic microenvironment in adrenal cancer cells and support future investigation of its role as a therapeutic kinase target in patients with ACC." 05/01/2010 - "Multiple kinase inhibitors such as sorafenib provide targeted oncologic treatment and may be effective in treating advanced adrenal cancer." 01/01/1979 - "This novel autophosphorylating, cAMP-binding, protein kinase may be a characteristic of certain adrenal neoplasms."
4.	Dichlorodiphenyldichloroethane (DDD)IBA 02/01/1988 - "Only an effective agent for the adrenal cancer is op'-DDD so far. "
5.	Sorafenib (BAY 43-9006)FDA Link 05/01/2010 - "Multiple kinase inhibitors such as sorafenib provide targeted oncologic treatment and may be effective in treating advanced adrenal cancer."
6.	mitomethIBA 01/01/1993 - "This observation prompted us to undertake a comparative study of these two drugs on the basis that Mitometh may be a superior agent for the treatment of adrenal cancer. " 01/01/1993 - "We conclude that Mitometh is not likely to be effective in the therapy of adrenal cancer. "
7.	Mitotane (Lysodren)FDA Link 11/01/2015 - "Adrenal gland: Cancer target of mitotane identified." 02/05/2015 - "RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization." 07/01/2012 - "Structural requirements for mitotane activity: development of analogs for treatment of adrenal cancer." 01/01/2005 - "Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up." 01/01/1993 - "Mitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity. "
8.	Hormones (Hormone)IBA 02/01/2023 - "Adrenal gland neoplasms can be hormone-active or hormone-inactive. " 01/01/2017 - "Adrenal neoplasms can be asymptomatic or can overproduce certain hormones that lead to different clinical manifestations. " 05/01/1995 - "According to the hormone profile, the next diagnostic step should be aimed at detecting a prospective ovarian or adrenal neoplasm." 05/28/2021 - "Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal gland that is frequently associated with excess production of adrenal hormones. " 10/01/1990 - "A 34-year-old man had a huge hormone-producing adrenal cancer with multiple lung metastases, direct liver invasion and a tumor thrombus in the inferior vena cava. "
9.	Proteins (Proteins, Gene)FDA Link 12/01/2010 - "Expression of Bcl-2 and Bcl-XL proteins was determined in two human adrenal cancer cell lines, NCI-H-295 and RL-251. " 01/01/1997 - "Radiolabeling of the proteins of a human adrenal cancer cell line NCI H-295 was weak, but a band at 11.5 kDa was detected. " 01/01/2024 - "Additionally, proteomics has been used to investigate the variations in protein expression in adrenal cancers and conditions, including Cushing's syndrome and Addison's disease. " 12/01/2014 - "This study also described, for the first time, a comprehensive protein expression profile of activin-βC in reproductive and adrenal cancers, and its effect on a human granulosa cell line, providing evidence for a role in ovarian, testis and adrenal tumour biology. " 01/01/2021 - "Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms."
10.	DNA (Deoxyribonucleic Acid)IBA 02/01/1992 - "Studies on pathological morphology, clinical features and nuclear DNA contents by flow cytometry in adrenal neoplasms." 01/01/2014 - "This is the first reported case with DNA analysis, which demonstrated the loss of heterozygosity (LOH) at the NF1 locus in the adrenal cancer, supporting the hypothesis of an involvement of the NF1 gene in the pathogenesis of ACC. " 01/01/2000 - "Complete direct DNA sequencing data of the entire coding region and adjacent splice sites of the MEN I gene were obtained in 14 patients with sporadic adrenal cancer. " 08/25/1999 - "For all cases with amplifiable DNA, there was a 100% concordance rate for LOH between cytologic and histologic material, with at least 7 of the 10 cytologic samples originating from metastatic lesions and all of the surgical material originating from the primary adrenal neoplasm. " 02/01/1992 - "Pathological morphology, clinical features and nuclear DNA contents determined by flow cytometry (FCM) were studied in 11 cases of normal adrenals and 41 cases of adrenal neoplasms. "

Therapies and Procedures

1.	Adrenalectomy 10/01/2005 - " adrenalectomy is a safe and effective treatment for adrenal disorders, excluding primary adrenal cancer. " 11/01/1994 - "We conclude that laparoscopic adrenalectomy is a safe and effective, minimally invasive approach for patients with benign adrenal neoplasms." 01/01/2018 - "To study surgical features of laparoscopic adrenalectomy in patients with large adrenal neoplasms. " 12/01/2004 - "We review studies on the outcome of laparoscopic adrenalectomy for primary adrenal cancer as well as studies on metastatic disease to the adrenal glands. " 11/01/2001 - "The aim of this study was to compare the outcome of laparoscopic adrenalectomy (LA) performed for benign adrenal neoplasm to the open procedure in a similar group of patients. "
2.	Therapeutics 01/01/2016 - "Recent advances in the molecular understanding of adrenal cancer offer promise for better therapies in the future. " 09/01/2005 - "In addition to setting up guidelines in specific areas of the diagnosis and treatment of adrenal cancer, the conference recommended and initiated the planning of an international prospective trial for treatment of patients with adrenal cancer in stages III and IV. In terms of new therapies, first trials of dendritic cell therapy in human subjects with adrenal cancer have been started, but it is too early to comment on efficacy. " 02/01/2016 - "Systemic Therapy in Locally Advanced or Metastatic Adrenal Cancers: A Critical Appraisal and Clinical Trial Update." 12/01/2012 - "Whenever adrenal cancer (ACC) is completely removed we should face the dilemma to treat by means of adjuvant therapy or not. " 10/01/2012 - "Systemic therapy for advanced adrenal cancer."
3.	Radiofrequency Ablation 01/01/2011 - "Efficacy of radiofrequency ablation in the treatment of small functional adrenal neoplasms." 09/01/2005 - "Adrenal neoplasms: CT-guided radiofrequency ablation--preliminary results." 04/01/2004 - "Adrenal neoplasms: CT-guided radiofrequency ablation--preliminary results." 09/01/2009 - "Percutaneous techniques to treat adrenal neoplasms have been described including radiofrequency ablation, cryoablation, and chemical ablation. " 02/01/2003 - "The current study was performed to analyze the feasibility, safety, imaging appearance, and short-term efficacy of image-guided percutaneous radiofrequency ablation (RFA) of primary and metastatic adrenal neoplasms including adrenocortical carcinoma. "
4.	Operative Surgical Procedures 01/01/2018 - "Laparoscopic adrenalectomy for adrenal neoplasms from 5 to 8-9 cm is feasible, effective and safe surgical procedure. "
5.	Drug Therapy (Chemotherapy) 11/01/2011 - "Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?" 12/01/2010 - "Expression of anti-apoptosis genes determines the response of adrenal cancer to apoptosis-inducing chemotherapy." 12/01/2016 - "The main types of treatment for adrenal cancer are surgery (the main treatment), chemotherapy and targeted therapy. " 07/01/1998 - "He was diagnosed with Cushing's syndrome attributable to metastatic adrenal cancer that progressed despite chemotherapy. " 01/01/2017 - "Mitotane is the most important drug in adrenal cancer chemotherapy. "