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Adrenal Cortex Neoplasms (Adrenocortical Cancer)

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Tumors or cancers of the ADRENAL CORTEX.

Also Known As:

Adrenocortical Cancer; Adrenal Cortex Cancer; Cancer of the Adrenal Cortex; Neoplasms, Adrenal Cortex; Adrenal Cortex Cancers; Adrenal Cortex Neoplasm; Adrenocortical Cancers; Cancer, Adrenal Cortex; Cancer, Adrenocortical; Cancers, Adrenal Cortex; Cancers, Adrenocortical; Neoplasm, Adrenal Cortex; Cancer of Adrenal Cortex

Networked: 161 relevant articles (9 outcomes, 15 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Beckwith-Wiedemann Syndrome (Exomphalos Macroglossia Gigantism Syndrome)
3.	Adrenocortical Hyperfunction (Adrenal Gland Hyperfunction)
4.	Adrenocortical Adenoma (Disease, Conn's)
5.	Hyperplasia

Experts

1.	Mannelli, Massimo: 9 articles (03/2015 - 03/2005)
2.	Bertagna, Xavier: 9 articles (01/2013 - 11/2002)
3.	Bertherat, Jérôme: 9 articles (01/2013 - 11/2002)
4.	Luconi, Michaela: 7 articles (03/2015 - 01/2008)
5.	Groussin, Lionel: 7 articles (10/2008 - 11/2002)
6.	Terzolo, Massimo: 6 articles (02/2015 - 12/2008)
7.	Tissier, Frédérique: 6 articles (01/2013 - 09/2005)
8.	Cerquetti, Lidia: 5 articles (05/2015 - 08/2010)
9.	Stigliano, Antonio: 5 articles (05/2015 - 08/2010)
10.	Poli, Giada: 5 articles (03/2015 - 01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adrenal Cortex Neoplasms:

1.	Mitotane (Lysodren)FDA Link 05/15/1993 - "These findings do not support the conclusion that adjuvant mitotane is beneficial in patients with localized or regional adrenocortical cancer. " 08/16/2012 - "In this study, we explored the molecular effect of mitotane on steroidogenesis in human adrenocortical cancer NCI-H295 cells. " 12/01/2008 - "Seventeen consecutive patients who were treated with mitotane after radical resection of adrenocortical cancer (ACC) from 1999 to 2005 underwent physical examination, routine laboratory evaluation, monitoring of mitotane concentrations, and a hormonal work-up at baseline and every 3 months till ACC relapse or study end (December 2007). " 11/01/2015 - "We report the case of toxic plasma levels with low doses of mitotane in a 47-year-old man with adrenocortical cancer. " 02/05/2015 - "These data demonstrate that RRM1 gene interferes with mitotane metabolism in adrenocortical cancer cells, as a possible mechanisms of drug resistance. "
2.	MicroRNAs (MicroRNA)IBA 04/01/2015 - "Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer." 01/01/2013 - "To survey the mechanisms involving gene alteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetration to build a regulatory network. " 06/01/2010 - "Our results reveal a novel mechanism of regulation of mTOR signaling by miRNAs, and they lay the groundwork for clinical evaluation of drugs inhibiting the mTOR pathway for treatment of adrenocortical cancer." 03/01/2014 - "In contrast, of the selected eight miRNAs reported in the literature as differentially expressed in ACT tissues, five (hsa-miR-100, hsa-miR-181b, hsa-miR-184, hsa-miR-210 and hsa-miR-483-5p) showed a statistically significant overexpression in adrenocortical cancer vs adenoma when normalized on hsa-miR-16 as a reference gene. " 10/01/2012 - "Studies using new genomic approaches including mRNA, miRNA, methylation, and CGH profiling have identified dysregulated genes and pathways that may have clinical implications in improved molecular diagnosis and prognostication of adrenocortical cancer (ACC). "
3.	Messenger RNA (mRNA)IBA 10/01/2012 - "Studies using new genomic approaches including mRNA, miRNA, methylation, and CGH profiling have identified dysregulated genes and pathways that may have clinical implications in improved molecular diagnosis and prognostication of adrenocortical cancer (ACC). " 01/01/2011 - "In this review, the authors attempt to summarize the main findings of mRNA and microRNA expression microarray studies performed to date in adrenocortical cancer including a recent meta-analysis of gene expression data and present novel pathogenic pathways." 09/01/2012 - "We have studied mitotane-induced mRNA expression changes in the NCI-H295R adrenocortical cancer cell line. " 01/01/2011 - "mRNA and microRNA expression patterns in adrenocortical cancer."
4.	Suramin (Suramin Sodium)IBA 09/01/1994 - "Suramin in adrenocortical cancer: limited efficacy and serious toxicity." 12/01/1991 - "Suramin, a sulfonated drug, has been used successfully in the treatment of inoperable adrenocortical cancer. " 10/01/1991 - "Suramin, a polycyclic and polyanionic drug, has been successfully used in the therapy of inoperable adrenocortical cancer. " 09/01/1997 - "Suramin inhibits growth of neural crest-derived cells and is used to treat adrenocortical cancer and neuroblastoma in clinical trials. " 04/01/1992 - "The antitrypanosomal and antifiliarial drug suramin is currently under investigation for treatment of advanced malignancies including prostatic cancer, adrenocortical cancer, and some lymphomas and sarcomas. "
5.	HormonesIBA 03/01/2014 - "In conclusion, 9-cisRA might represent a promising new candidate in the treatment of hormone-secreting adrenal tumors and adrenocortical cancer. " 10/01/1991 - "Suramin may not only be useful in the treatment of adrenocortical cancer, but may also have an ameliorative effect on other malignant conditions with augmented steroid hormone production, resistant to conventional forms of therapy." 06/01/1971 - "Abnormal hormone responses of an adrenocortical cancer adenyl cyclase." 06/01/2010 - "To characterize intraadrenal adaptations for inhibition of cortisol synthesis, we analyzed the effects of etomidate (ETO) on steroid hormone secretion and expression of key regulators of steroidogenesis and proliferation in human NCI-h295 adrenocortical cancer cells. " 04/15/1987 - "Treatment of hormone-producing adrenocortical cancer with o,p'DDD and streptozocin."
6.	Streptozocin (Streptozotocin)FDA Link 10/01/2000 - "To evaluate the efficacy of streptozocin and o.p'DDD (SO) in adrenocortical cancer (ACC) patients since other chemotherapeutic regimens have limited effects. " 10/01/2000 - "Streptozocin and o,p'DDD in the treatment of adrenocortical cancer patients: long-term survival in its adjuvant use." 04/15/1987 - "Treatment of hormone-producing adrenocortical cancer with o,p'DDD and streptozocin." 12/01/2011 - "Standard chemotherapy for adrenocortical cancer currently is under evaluation in the context of the recently completed FIRM-ACT evaluating the combination of mitotane with either streptozocin or etoposide, cisplatin, and doxorubicin. "
7.	Sirolimus (Rapamycin)FDA Link 11/25/2012 - "We tested the effect of a novel PI3 kinase - mammalian target of rapamycin dual inhibitor (NVP-BEZ235) on proliferation of the H295R adrenocortical cancer cell line in vitro and grown as xenografts in immunodeficient mice. " 08/01/2012 - "Based on the efficacy of sorafenib, a tyrosine kinase inhibitor, and everolimus, an inhibitor of the mammalian target of rapamycin in tumors of different histotype, we aimed at testing these drugs in adrenocortical cancer models. "
8.	Insulin (Novolin)FDA Link 11/01/2006 - "The identification of germline genetic defects in familial diseases associated with adrenocortical tumors helped to define the somatic alterations in sporadic disease: for example, overexpression of insulin-like growth factor 2 and alterations at the 11p15 locus (observed in Beckwith-Wiedemann syndrome) are also found in most adrenocortical cancers. " 04/01/2012 - "Bitter melon (Momordica charantia) extract suppresses adrenocortical cancer cell proliferation through modulation of the apoptotic pathway, steroidogenesis, and insulin-like growth factor type 1 receptor/RAC-α serine/threonine-protein kinase signaling."
9.	everolimus FDA Link 08/01/2013 - "Everolimus therapy for progressive adrenocortical cancer." 08/01/2012 - "Based on the efficacy of sorafenib, a tyrosine kinase inhibitor, and everolimus, an inhibitor of the mammalian target of rapamycin in tumors of different histotype, we aimed at testing these drugs in adrenocortical cancer models. "
10.	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 06/15/2012 - "Ribonucleotide reductase large subunit (RRM1) gene expression may predict efficacy of adjuvant mitotane in adrenocortical cancer."

Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation) 03/31/2012 - "Xenograft models for preclinical drug testing: implications for adrenocortical cancer." 01/01/2010 - "In both pituitary and adrenocortical cancer, RGZ treatment results in inhibition of cell proliferation, through G0/G1 cell-cycle arrest and induction of cell apoptosis, leading to significant inhibition of tumor growth in the xenograft tumor models. " 03/01/2010 - "Rosiglitazone impairs proliferation of human adrenocortical cancer: preclinical study in a xenograft mouse model." 09/01/2010 - "Mitotane effects in a H295R xenograft model of adjuvant treatment of adrenocortical cancer." 11/25/2012 - "We tested the effect of a novel PI3 kinase - mammalian target of rapamycin dual inhibitor (NVP-BEZ235) on proliferation of the H295R adrenocortical cancer cell line in vitro and grown as xenografts in immunodeficient mice. "
2.	Adrenalectomy 04/01/2014 - "Open radical adrenalectomy should be offered to children with adrenocortical cancers. " 01/01/2013 - "The unnecessary number of adrenalectomies performed in understudied patients, causing higher morbidity, was not associated to a higher detection rate of primary adrenocortical cancer." 05/01/2010 - "Retrospective evaluation of the outcome of open versus laparoscopic adrenalectomy for stage I and II adrenocortical cancer." 01/01/2009 - "Open adrenalectomy continues to be the most appropriate for adrenocortical cancer. " 12/01/2004 - "Right adrenalectomy was performed, and histological diagnosis was again adrenocortical cancer. "
3.	Drug Therapy (Chemotherapy) 05/01/2015 - "We examined the c-Myc protein expression in adrenocortical cancer (ACC) cells to investigate the role of this protein in the neoplasm, its involvement in chemotherapy and finally to determine whether c-Myc could be considered a prognostic factor in patients with ACC. " 04/01/1991 - "In a retrospective, nonrandomized comparison of patients with first recurrence of adrenocortical cancer, 18 patients were treated with chemotherapy (primarily mitotane) and 15 patients were treated with surgical resection plus similar chemotherapy. " 01/01/2015 - "Current first-line chemotherapy for patients with metastatic adrenocortical cancer (ACC) includes doxorubicin, etoposide, cisplatin, and mitotane with a reported response rate of only 23.2%. " 12/01/2011 - "Standard chemotherapy for adrenocortical cancer currently is under evaluation in the context of the recently completed FIRM-ACT evaluating the combination of mitotane with either streptozocin or etoposide, cisplatin, and doxorubicin. "
4.	Radiotherapy 01/01/2012 - "p53 Stabilization induces cell growth inhibition and affects IGF2 pathway in response to radiotherapy in adrenocortical cancer cells." 06/01/2006 - "The following search terms were used in varying combinations: adrenal, adrenocortical, cancer, carcinoma, tumor, diagnosis, imaging, treatment, radiotherapy, mitotane, cytotoxic, surgery. "
5.	Combination Drug Therapy (Combination Chemotherapy) 05/01/1995 - "Feasibility of the association of mitotane with etoposide, adriamycin and cisplatin combination chemotherapy in advanced adrenocortical cancer patients. "