Adie Syndrome

A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupillary constrictor muscle. (From Adams et al., Principles of Neurology, 6th ed, p279)

Also Known As:

Networked: 29 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Gingivitis
2.	Tonic Pupil
3.	Anisocoria
4.	Primary Dysautonomias (Dysautonomia)
5.	Seminoma

Experts

1.	Takahashi, Kan: 1 article (04/2015)
2.	Aoi, Ryota: 1 article (04/2015)
3.	Ishihara, Mariko: 1 article (04/2015)
4.	Herrera-Jimenez, Isis Pamela: 1 article (08/2014)
5.	Garza Leon, Manuel: 1 article (08/2014)
6.	González-Madrigal, Pedro Mario: 1 article (08/2014)
7.	Jaryal, Ashok: 1 article (04/2013)
8.	Jain, Puneet: 1 article (04/2013)
9.	Arya, Ravindra: 1 article (04/2013)
10.	Gulati, Sheffali: 1 article (04/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adie Syndrome:

1.	Prednisone (Sone)FDA LinkGeneric 05/01/1997 - "Prednisone and antimalarial drugs were ineffective in treating Adie syndrome but improved the necrotizing gingivitis. "
2.	Antimalarials (Antimalarial Agents)IBA 05/01/1997 - "Prednisone and antimalarial drugs were ineffective in treating Adie syndrome but improved the necrotizing gingivitis. "
3.	Pilocarpine (Ocusert)FDA LinkGeneric 01/01/1985 - "Our study suggests those patients with Adie's Syndrome who lack stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity improves following a single drop of 0.1% pilocarpine. " 01/01/1985 - "Impressed by the benefit two patients with Adie's Syndrome derived from topical 0.1% pilocarpine therapy, we performed the present study to examine the measurable effects of 0.1% pilocarpine in several patients with this syndrome. " 06/01/1997 - "The 0.1% pilocarpine test confirmed a diagnosis of Adie's syndrome. " 01/01/1985 - "The therapy of Adie's syndrome with dilute pilocarpine hydrochloride solutions." 12/01/1984 - "A symptomatic patient with Adie's syndrome is described as successfully managed with pilocarpine 0.125% applied topically to the involved eye three times daily. "
4.	Methacholine Chloride (Methacholine)FDA Link 09/01/1982 - "Plasma cyclic nucleotide responses to methacholine in patients with Adie's syndrome." 09/01/1982 - "In order to examine the clinical usefulness of methacholine in assessing the site of ocular parasympathetic lesions, pupillary responses in man were measured in postganglionic (Adie's syndrome) and preganglionic third nerve lesions involving the pupil and in controls. " 10/01/1965 - "Adie's syndrome: duration of methacholine sensitivity." 12/01/1953 - "Adie's syndrome and the Adler-Scheie mecholyl test." 09/01/1982 - "Methacholine pupillary responses in third nerve palsy and Adie's syndrome."
5.	Harlequin syndromeIBA 04/01/2013 - "Her clinical presentation can be categorized as partial overlap between Harlequin syndrome and Holmes-Adie syndrome." 12/01/1993 - "The finding of cholinergic supersensitivity in the iris muscles of patients with harlequin syndrome indicates a relationship with Holmes-Adie syndrome, Ross's syndrome, and the persistent autonomic deficit occasionally associated with Guillain-Barré syndrome." 08/01/1993 - "Unilateral loss of facial flushing and sweating with contralateral anhidrosis: harlequin syndrome or Adie's syndrome?" 04/01/2013 - "Harlequin syndrome, Harlequin sign, Holmes-Adie syndrome, and Ross syndrome lie on a spectrum of partial dysautonomias affecting facial sudomotor, vasomotor, and pupillary responses. " 09/01/2008 - "Among the patients with harlequin syndrome who also have tonic pupils and tendon areflexia (Holmes-Adie syndrome), we postulate a ganglionopathy affecting not merely the (sympathetic) superior cervical ganglion, but also the (parasympathetic) ciliary and dorsal root ganglia. "
6.	AntibodiesIBA 12/31/1977 - "A search for serum antibodies in Adie's syndrome." 01/11/2005 - "Anti-Hu antibodies, sensory neuropathy, and Holmes-Adie syndrome in a patient with seminoma."
7.	Fluorescein (Funduscein)FDA LinkGeneric 04/01/1983 - "In senile iris atrophies, Adie's syndrome and congenital albinism the iris vascular structure is basically normal, but atrophy of the iris stroma may lead to increased fluorescein permeability in the elderly."
8.	PhysostigmineIBA 10/01/1980 - "Low concentration eserine therapy for the tonic pupil (Adie) syndrome."
9.	ParasympathomimeticsIBA 01/01/1985 - "Potential problems concerning medical therapy of Adie's Syndrome with parasympathomimetics are discussed."
10.	Cyclic GMPIBA 08/01/1981 - "[Enhanced plasma cyclic GMP responses to methacholine in patients with Adie's syndrome (author's transl)]."

Therapies and Procedures

1.	Denervation 02/01/1998 - "This study aimed to analyze the denervation and reinnervation history of individual segments of the iris sphincter in patients with Adie's syndrome. " 02/01/1965 - "PROGRESSIVE SUDOMOTOR DENERVATION AND ADIE'S SYNDROME." 11/01/1958 - "Progressive selective sudomotor denervation; a case with coexisting Adie's syndrome." 02/01/1998 - "A total of 61 patients with Adie's syndrome or Adie's-like denervation of the iris sphincter (from surgery, trauma, or radiation) and 10 normal subjects were studied. " 07/01/1978 - "The accepted hypothesis for the pathophysiology of tonic pupil syndrome (Adie syndrome) was reexamined in light of recent developments concerning denervation supersensitivity of cholinergically innervated smooth muscle. "
2.	Anesthesia 04/01/2015 - "Anisocoria after anesthesia induction caused by Adie syndrome." 09/01/2012 - "This article reports the case of a patient with known Adie's syndrome where anisocoria led to an unnecessary immediate interruption of anesthesia. "
3.	General Anesthesia 02/01/2008 - "Adie syndrome associated with general anesthesia."